Typhoid fever

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Typhoid fever

  1. 1. Typhoid Fever BIO 106 9/5/2012 Francisco Rodriguez
  2. 2. HistoryThe Plague of Athens Sparta Pericles Source: Encyclopædia Britannica
  3. 3. US – 1907Mary Mallon (Typhoid Mary)Source: PBS
  4. 4. What is Typhoid Fever?Acute infectious disease affects 17 million peopleworldwide every year, with approximately 600,000 deathsSerotype of the bacterium Salmonella typhiEnters the body through the mouthContaminated food or waterPenetrates intestinal wallEnters bloodstream in 24-72 hrs.Causes septicemia and systemic infection
  5. 5. Salmonella Typhi under the microscope
  6. 6. Symptoms 10-14 day incubation periodHeadacheMalaiseGeneralized achingFever (103-104 ̊F)Loss of appetiteNosebleedsCoughDiarrheaSmall rose-colored spots appear on the trunkExtremes emaciation and mental disturbance
  7. 7. Complications25% are fatal casesHeart failurePneumoniaOsteomyelitisEncephalitisMeningitisMental confusion and delirium
  8. 8. Diagnosis and TreatmentDiagnosed via blood culture, stoolculture and serological testing.Treated with antibiotics, specificallychloramphenicol
  9. 9. Areas at Risk
  10. 10. WarningsTyphoid bacteria can persist in the bilepassages of patients for an indefinite periodof time.The risk is in travelers who leave industrializedzones for third world countries and return.(400 cases/year in the U.S.)
  11. 11. Resourcestyphoid fever (typhoid). (2006). In Dictionary of Microbiology &Molecular Biology. Retrieved fromhttp://databases.mail.wvncc.edu:2055/entry/wileymicrob/typhoid_fever_typhoidtyphoid fever. (2012). In Encyclopædia Britannica. Retrieved fromhttp://databases.mail.wvncc.edu:2067/EBchecked/topic/611776/typhoid-feverPapagrigorakis MJ, Yapijakis C, Synodinos PN, Baziotopoulou-Valavani E(2006). "DNA examination of ancient dental pulp incriminates typhoidfever as a probable cause of the Plague of Athens". Int J Infect Dis 10 (3):206–214.typhoid. (2009). In Britannica Concise Encyclopedia. Retrieved fromhttp://databases.mail.wvncc.edu:2055/entry/ebconcise/typhoid
  12. 12. YouTube Videohttp://www.youtube.com/watch?feature=player_embedded&v=N54STudBsys

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