Cpl In Draft Horses

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basic presentation on CPL

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  • INTRO: UA, carriere ucdavis, dermatopathologie, problemen onderste ledematen shires –clydesdales, cpl - contact met gent btp parallel met ucdavis
  • Cpl In Draft Horses

    1. 1. CHRONIC PROGRESSIVE LYMPHEDEMA IN DRAFT HORSES Prof. Dr. H. De Cock University of Antwerp
    2. 2. CPL IN DRAFT HORSES <ul><li>Lymphatics of the skin </li></ul><ul><li>What is lymphedema? </li></ul><ul><li>Causes of lymhedema </li></ul><ul><li>CPL in draft horses </li></ul><ul><ul><li>Clinical signs - histology </li></ul></ul><ul><ul><li>Diagnosis </li></ul></ul><ul><ul><li>Treatment </li></ul></ul>
    3. 3. 1.The lymphatic system of the skin
    4. 6. 2. What is lymphedema? <ul><li>Lymph vessels are abnormal in structure (congenital malformation or secondary to trauma) -> accumulation of fluids in tissue -> tissue swelling -> hypoxia of tissue -> skin fibrosis (hardening), hyperkeratosis and secondary bacterial infections (not proper functioning of immune system) </li></ul>
    5. 7. 3. Causes <ul><li>Primary lymphedema: congenital malformation or malfunctioning of lymphatics (CPL most likely) </li></ul><ul><li>Secondary lymphedema: after trauma or infection skin </li></ul>
    6. 8. 4. CPL in draft horses <ul><li>Clinical signs: </li></ul><ul><li>Starts with mild enlargement distal limbs -> skin folds in pastern region -> hyperkeratosis and ulceration skin -> swelling becomes hard and nodular -> secondary skin infections -> lymphangitis </li></ul>
    7. 9. CPL mild lesions Scratches or pastern dermatitis looks similar in initial stages
    8. 10. Lymphedema ≠ Scratches Cause is poor function of lymph vessels Many possible causes Slowly progressive Usually does not progress No or minimal improvement with regular treatment Cure with good treatment All 4 limbs affected 1 or 4 limbs affected
    9. 20. Lymphangiography
    10. 21. Histology <ul><li>Extremely dilated and degenerated lymphatics, proliferation of blood vessels (hypoxia), edema, inflammation and degenerated elastin surrounding the lymphatics in CPL </li></ul>
    11. 22. Normal lymphatic In CPL
    12. 23. Normal lymphatic In CPL
    13. 24. Elastin difference between normal (left) and CPL (right)
    14. 25. Diagnosis <ul><li>Most importantant are clinical signs </li></ul><ul><li>Lymphoscintigraphy possible but not routinely performed </li></ul><ul><li>Anti-elastin antibodies rise in serum (ELISA test performed at University of Antwerp) </li></ul>
    15. 26. Treatment in humans <ul><li>Good skin care </li></ul><ul><li>Elastic bandages </li></ul><ul><li>Exercise </li></ul><ul><li>Manual lymph drainage </li></ul>
    16. 27. Treatment in horses <ul><li>Good skin care -> prevention trauma and irritation </li></ul><ul><ul><li>Chorioptes mites prevention </li></ul></ul><ul><ul><li>Wound care </li></ul></ul><ul><ul><li>Dry skin </li></ul></ul>Reason: irritation and inflammation increases lymph stasis in legs
    17. 28. treatment <ul><li>2. Supportive elastic bandages, life long and as much as possible </li></ul>Reason: pushes accumulated fluid out of the skin
    18. 29. treatment <ul><li>3. Lots of exercise </li></ul>Reason: muscle movement pushes fluid out of the tissues
    19. 30. treatment <ul><li>Manual lymph drainage </li></ul><ul><li>Few people know how to do this in the horse ≠ regular massage </li></ul>Reason: pushes accumulated fluid out of the skin
    20. 31. Results of treatment: lesions before and after treatment
    21. 32. Met dank aan iedereen die meewerkte aan het project: Eigenaars Dierenartsen Leen Van Brantegem (UA) Verena Affolter & Greg Ferraro (UCDavis) Prof. Ducatelle (UGent) Technisch personeel UA, UGent & UCDavis

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