Archive, Mine, Collaborate ® Community-Based Approaches to Neglected Disease R&D Collaborative Drug Discovery, Inc. Barry A. Bunin PhD Forum One Communications: Web Executive Seminar November 13, 2007

Community-Based Approaches to Neglected Disease R&D

Web Executive Seminars Global Health and the Internet: How Can We Save More Lives? November 13, 2007 National Press Club Washington, DC

Archive, Mine, Collaborate ® Community-Based Approaches to Neglected Disease R&D Collaborative Drug Discovery, Inc. Barry A. Bunin PhD Forum One Communications: Web Executive Seminar November 13, 2007

Community-Based Approaches to Neglected Disease R&D

Founded in 2004, conceived in 2003 Based in Burlingame, CA Focus: Empowering research communities encompassing academics, non-profits, and for-profit companies. About Us

Founded in 2004, conceived in 2003

Based in Burlingame, CA

Focus: Empowering research communities encompassing academics, non-profits, and for-profit companies.

Advance drugs for neglected diseases rapidly from lab to clinic. Align research priorities to confront global health challenges. Integrate dispersed labs into a virtual pharmaceutical organization. Include and interconnect everyone who wants to help. The Vision

Advance drugs for neglected diseases rapidly from lab to clinic.

Align research priorities to confront global health challenges.

Integrate dispersed labs into a virtual pharmaceutical organization.

Include and interconnect everyone who wants to help.

Promote discoveries that would not otherwise happen. Utilize limited resources more effectively. Accelerate the discovery of effective treatments for neglected infectious diseases. Save time Save money Save lives Our Goals

Promote discoveries that would not otherwise happen.

Utilize limited resources more effectively.

Accelerate the discovery of effective treatments for neglected infectious diseases.

Where CDD adds value

New Approach to Global Health Problems Neglected disease strategic focus – community-based approach Benefits for participating in the community: New insights from integrating different experts Faster target validation and drug discovery Instantaneous access Optimizing use of resources Avoids duplication Make new connections New Approach to Global Health Problems

Neglected disease strategic focus – community-based approach

Benefits for participating in the community:

New insights from integrating different experts

Faster target validation and drug discovery

Instantaneous access

Optimizing use of resources

Avoids duplication

Make new connections

Archive In many labs today: paper systems and Excel dominate With CDD: teams can easily upload and archive data online, enabling: Focus on neglected disease research Data mining and collaboration within and among research groups

With CDD:

teams can easily upload and archive data online, enabling:

Focus on neglected disease research

Data mining and collaboration within and among research groups

Mine

Collaborate Result New leads reveal known drugs that reverse chloroquinine resistance

CDD R&D Network

Securely manage your public & private collaborations

Respect IP

Benefits for R&D Archiving data Recordkeeping, continuity, & efficiency Mining data Relevance – understanding & knowledge Helps advance promising drugs Collaborating with data Keep your data 100% private, exchange confidentially with collaborators, or share openly with the scientific community. Publications, collaborations, peer recognition

Archiving data

Recordkeeping, continuity, & efficiency

Mining data

Relevance – understanding & knowledge

Helps advance promising drugs

Collaborating with data

Keep your data 100% private, exchange confidentially with collaborators, or share openly with the scientific community.

Publications, collaborations, peer recognition

Personal legacy if and when you leave Ability to access your data anywhere, anytime Much more likely to discovery/advance a real drug candidate Access to rest of the group data Become sophisticated with modern informatics technologies – a relevant skill for the rest of your career Better chance to get employed Benefits for Students

Personal legacy if and when you leave

Ability to access your data anywhere, anytime

Much more likely to discovery/advance a real drug candidate

Access to rest of the group data

Become sophisticated with modern informatics technologies – a relevant skill for the rest of your career

Better chance to get employed

Why try? Evolution of Personal Interests Started in the laboratory with highly empirical experiments Moved from bench to doing community-wide experiments Collaborative Drug Discovery

Started in the laboratory with highly empirical experiments

Moved from bench to doing community-wide experiments

Collaborative Drug Discovery

What the community can do that the individual can’t Case study for web2.0 for science Incentives for researchers, benefits for them, benefits for us, how win-win Challenges Future directions CDD: Past, Present, & Future

What the community can do that the individual can’t

Case study for web2.0 for science

Incentives for researchers, benefits for them, benefits for us, how win-win

Challenges

Future directions

"When this really takes off, and I expect it will, you'll be the MySpace or YouTube of the biotech community."

"When this really takes off, and I expect it will,

you'll be the MySpace or YouTube of the biotech community."

Collaborative Drug Discovery Contact: Barry A. Bunin PhD Cell: (650) 219-4153 [email_address] Collaborative Drug Discovery, Inc.

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