Perimenopause

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Perimenopause

  1. 1. Conditions that Increase in Risk with Perimenopause and Menopause<br /><ul><li>Cardiovascular Disease and Stroke
  2. 2. Osteoporosis
  3. 3. Dementia and Alzheimer’s Disease
  4. 4. Arthritis
  5. 5. Autoimmune Disease</li></li></ul><li>Health During A Woman’s Life<br />
  6. 6. Symptoms of Estrogen Decline<br />Hot flashes<br />Vaginal dryness<br />Changes in skin tone<br />Depression<br />Poor concentration and memory<br />Irregular periods<br />Hair loss and thinning<br />Pain and inflammation<br />Weight gain<br />Decreased memory and cognitive function<br />Dysglycemia<br />
  7. 7. Typical Management of Menopause<br />
  8. 8. Changes in pro-inflammatory activity after menopause<br />There is now a large body of evidence suggesting that the<br />decline in ovarian function with menopause is associated with<br />spontaneous increases in pro-inflammatory cytokines.<br />
  9. 9. Conditions that Increase in Risk with Perimenopause and Menopause<br /><ul><li>Cardiovascular Disease and Stroke
  10. 10. Osteoporosis
  11. 11. Dementia and Alzheimer’s Disease
  12. 12. Arthritis
  13. 13. Autoimmune Disease</li></li></ul><li>Why do some women have a smoother process than others?<br />When the female hormone production starts to fluctuate the adrenal system is supposed to take over.<br />The adrenal gland produces a hormone (androstenedione) that gets converted to estrogen in the fatty tissues<br />If the adrenal system is strong, it compensates the loss of estrogen and the transition is smooth<br />
  14. 14. What if the Adrenals are weak?<br />There is no compensation for estrogen loss<br /> this will lead to hormone fluctuations in the body<br />all the typical symptoms will occur.<br />
  15. 15. Symptoms of Estrogen Decline<br />Hot flashes<br />Vaginal dryness<br />Changes in skin tone<br />Depression<br />Poor concentration and memory<br />Irregular periods<br />Hair loss and thinning<br />Pain and inflammation<br />Weight gain<br />Decreased memory and cognitive function<br />Dysglycemia<br />
  16. 16. In addition potentially devastating mechanisms are getting activated:<br />There is six factors that cause systemic inflammation in Perimenopause<br />Those factors potentiate each other and have devastating effects on cell aging and tissue breakdown<br />Hormone replacement is not addressing those mechanisms since they stay active once triggered<br />
  17. 17. First mechanism:<br />If there is a decline in Estrogen levels (specifically estradiol) in a female patient in premenopause, the inflammatory cytokine system is up-regulated and may stay up-regulated EVEN AFTER ESTROGEN LEVELS ARE RESTORED.<br />Depending pre-existing inflamed areas in the body this up-regulation will determine which systems are most impacted by this process.<br />
  18. 18. Preixisting Activity?<br />Immune activation (which can lead to autoimmune diseases)<br />Neuro-inflammation (which can lead to dementia, and many other neurological conditions)<br />Free Radicals (increased cancer risk)<br />Higher stress response (individual loses ability to cope with stress)<br />Body fat (produces inflammatory agents)<br />
  19. 19. Second Mechanism<br />

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