Thyroid Disease
Upcoming SlideShare
Loading in...5
×

Like this? Share it with your network

Share

Thyroid Disease

  • 7,031 views
Uploaded on

http://www.dhmc.org/dhmc-internet-upload/file_collection/Thyroid%20Disease.ppt

http://www.dhmc.org/dhmc-internet-upload/file_collection/Thyroid%20Disease.ppt

  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
No Downloads

Views

Total Views
7,031
On Slideshare
4,383
From Embeds
2,648
Number of Embeds
4

Actions

Shares
Downloads
240
Comments
0
Likes
1

Embeds 2,648

http://clinicalmagazine.com 2,622
http://translate.googleusercontent.com 19
http://www.slideshare.net 6
http://cancervantage.com 1

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
    No notes for slide
  • Microcarcinoma (<1cm) Histologic variants which show more aggressive behavior and poorer prognosis
  • DX: which is why FNA cannot make the diagnosis of malignancy
  • Once thought to be a subset of follicular carcinoma, although now seen as its own entity based upon having its own oncogenic expression. More aggressive, evidenced by high….
  • Perhaps rare because thyroid cancers are being diagnosed earlier. Sometimes can be challenging to differentiate anaplastic ca from lymphoma, and on occasion will require open bx Patients generally die from airway compromise There was a small study at MGH involving ~60 pts who underwent extensive surgery and there was improved short-term survival compared with those without surgery. Surgery however is very extensive and may involve reconstructing the trachea, etc.
  • Sporadic MTC >20% somatic RET mutation
  • MENIIA: diagnosed 1 st – 3 rd decade, generally multifocal and bilateral MENIIB: far more aggressive, diagnosed in 1 st decade, multifocal and bilateral. Once manifests clinically, rarely curable. Familial: diagnosed in 5 th – 6 th decade, not as aggressive as MEN syndromes
  • Risk compared with general population FNA can sometimes be difficult to determine lymphoma from anaplastic ca, although new immunocytochemistry staining has helped No role for surgery
  • Sent by her PCP
  • Nodule: is it hard per patient, has she noticed a rapid increase in size? Any other lumps in her neck to suggest LAD? Symptoms: Most patients with cancer are asxs. Uncommonly patients will complain of hoarseness, dysphagia, dyspnea, coughing. Also ask whether patient has had any recent viral illnesses. FHx: Radiation exposure: Likely to be head and neck these days or total body for BMT. In the past, radiotherapy was used for tonsillar, thymic, and adenoid enlargement and acne in children
  • Now what?
  • Nodules 0.5 – 1cm can generally be palpated. Nodules larger than 4cm are worrisome. Firm nodules more worrisome than soft. (Diffuse irregular firm thyroid gland may indicate thyroiditis.
  • Now what?
  • Hot nodule may decrease the suspicion of malignancy Detecting metastases and therefore surveillance
  • Ultrasound can detect solid nodules 3-4mm and cystic nodules greater than 2mm. Uncommon to have purely cystic nodules, many are mixed. Purely solid nodules carry a higher risk of malignancy.
  • Halo sign is usually seen with benign lesions Calcifications  Psammoma bodies histologically seen in papillary cancer Because findings on ultrasound are not specific for cancer, FNA typically done at the same time.
  • Typically done in conjunction with ultrasound
  • Surgical options……
  • Contralateral nodules – high rate of multicentric disease Age – recurrence rates are higher in this age group
  • In that case…. Controversy here is that as mentioned previously, many of these cancers tend to be multicentric and therefore many proponents of near-total or total thryoidectomy. However, now with radioiodine ablation therapy there are more advocates of lobectomy with isthmusectomy to decrease risk to patient of injury to RLN and parathyroids.
  • These are the nodes most commonly involved in differentiated thyroid cancer 80% of the time metastasis occurs to this group of LN Some agrue that while positive LN occur in 20-30% of patients the clinical significance is unclear.
  • Level VI: called the central component or paraglandular space includes the prelaryngeal, pretracheal, and paratracheal LN in the tracheoesophageal groove, as well as the anterior superior mediastinal LN. Generally defined as extending from hyoid bone superiorly, innominate vein inferiorly, and carotid sheaths laterally. More extensive dissections are generally only called for with either known metastatic disease and in the case of medullary carcinoma
  • AMES scoring system stems from a study done in the late 1970, AGES originated from Mayo Clinic. The AGES system describes a scoring system for presence or absence of these factors. A score of less than 4 is associated with a 20-year mortality rate of less than 1%. The more advanced stages have 5-year survival rates approaching 50%.
  • Levothyroxine: differentiated thyroid cancer express the thyrotropin receptor and responds to TSH stimulation by increasing the rate of cell growth – used to decrease risk of recurrence
  • Lobectomy, knowing that they may need to have a completion thyroidectomy if tumor > 2cm and widely invasive pathology
  • Need to have adequate sample to demonstrate vascular or capsular invasion. Negative frozen section will not change your management.
  • Radioiodine ablation is not usually very effective for Hurthle cell, although may still recommend it.
  • Goal is to destroy residual thyroid tissue in an effort to decrease the risk of recurrent locoregional disease and to facilitate long-term surveillance with whole body iodine scans. Only studies available at this date are retrospective. According to these studies, benefit is only conferred to those patients with larger tumors (>1.5cm) or with residual disease after surgery. There is no clear benefit for low-risk patients.
  • T4a – includes invasion of subc tissue, trachea, esophagus and RLN T4b – invades prevertebral fascia or encases carotid or mediastinal vessels Level VI (pretracheal, paratracheal, prelaryngeal)
  • Thyroglobulin glycoprotein produced by normal thyroid tissue and after total thyroidectomy and radioiodine ablation therapy should be undetectable. Checked every 6-12 months for the first 1-2 years Endocrinologist is managing most of this
  • Locoregional disease: if surgery not feasible or not complete then proceed with radioiodine therapy, if this is unsuccessful then external beam radiation
  • Hypertension issues
  • Thought here being that in order to remove all thyroid tissue, it is best to remove the glands and then reimplant them. In patients with MEN2A, implantation should be done in the forearm, as easier access.
  • MTC cells do not take up radioiodine. Unfortunately XRT and chemo have not proved all that successful and long-term survival depends on complete surgical removal of the thyroid tissue
  • Thyroid gland extends from the cricoid cartilage covering the anterior tracheal rings wrapping around the anterolateral portion of the trachea. Consists of right and left lobes connected by the isthmus which usually extends anterior to the 2 nd and 3 rd tracheal rings. Not uncommonly, a pyramidal lobe is present extending superiorly to the hyoid bone from the isthmus. If fibrous band connection between the hyoid and pyramidal lobe it is termed the “levator of the thyroid gland” Posterior medial aspects of the thyroid lobes are attached to the cricoid cartilage by the ligament of Berry (aka suspensory ligament of the thyroid). Vascular anatomy: Although the thyroid accounts for only 0.4% of our body weight, it accounts for 2% of the total blood flow. It is estimated that during disease states, the flow through the gland can increase 100-fold. Superior thyroid artery (1 st branch off the external carotid) bifurcates into a dominant anterior and smaller posterior branch at the upper lobes. The external branch of the superior laryngeal nerve is often closely associated with the superior thyroid artery at the upper lobe and at risk for injury during dissection. Want to ligate the individual branches of this artery because ligating the main trunk risks injury to the nerve. The inferior thyroid artery emanates from the thyrocervical trunk and passes behind the carotid sheath. It is intimately associated with the RLN. Cannot neglect to mention the thyroid ima artery which is occasionally present and stems from the aorta or the innominate, entering the inferior aspect of the isthmus. Venous drainage: superior, middle, and inferior thryoid veins
  • The relationship between the external branch of the superior laryngeal nerve (black) and the superior thyroid artery. The nerve can course inferiorly and medially and may run partly along with or around the artery or the branches of the artery as they enter the superior lobe of the thyroid
  • Inability to tense the vocal cord, thereby unable to attain high-pitched notes or project one’s voice (professional speakers/singers)
  • This demonstrates the possible anatomic variations of the RLN. Fig A occurs in about 1% of the population. RLN is arising from the vagus at the level of the cricoid and directly enters the larynx. It can be mistaken for an arterial branch. (Left non-recurrent nerve very rare and usually associated with major arterial abnormalities.) Fig B the normal course of the RLN. Running posterior to the CCA then along the tracheoesophageal groove. It can pass behind, in front of, or between the branches of the ITA. It can also have a variant course with regard to the ligament of berry. Fig. C – Rare nonrecurrent nerve and recurrent laryngeal nerve join to form common distal nerve
  • The cord is immobilized in the paramedian position Many advocate monitoring the RLN intra-operatively. However this requires that the patient is not paralyzed.
  • Particularly at risk during thyroid surgery because of end artery blood supply. If this terminal branch of the ITA is damaged, it results in ischemic necrosis of the gland.

Transcript

  • 1. Thyroid Cancer May 10, 2006
  • 2. Thyroid Cancer
    • Accounts for 1.5% of all cancers in the US
    • Most common endocrine malignancy (95%)
    • 22,000 cases per year and estimated 500 – 1000 patients die annually
    • 90% of thyroid cancer cases have favorable prognosis
  • 3. Classification & Incidence of Thyroid Cancer
    • Follicular cell origin
    • Differentiated
      • Papillary 80%
      • Follicular 10%
      • Hurthle cell 3-5%
    • Undifferentiated
      • Anaplastic 1-2%
    • Parafollicular cell origin
    • – Medullary 5%
  • 4. Papillary Carcinoma
    • Accounts for 90% radiation induced cancer
    • Classified as microcarcinoma, intrathyroidal, and extrathyroidal
      • Histologic variants: tall-cell, clear-cell, columnar, diffuse sclerosing
    • Multicentric in 30-50% of tumors
    • Spreads via lymphatics with propensity for mid- and lower-anterior cervical chain (Level VI)
    • 20-50% patients have involvement of cervical LN
  • 5. Follicular Carcinoma
    • Only 10% of thyroid cancers in developed countries, although more prevalent in regions with iodine deficiency
    • Diagnosis depends on demonstration of vascular or capsular invasion
    • Classified as minimally or widely invasive
      • Vascular invasion tends to have a more aggressive course than capsular invasion
    • Uncommon to have multicentric disease
    • Hematogenous spread
  • 6. Follicular Carcinoma
    • Where does follicular carcinoma tend to metastasize?
    • Bone
    • Lung
  • 7. Hurthle Cell Carcinoma
    • High propensity to spread to cervical lymph nodes and high incidence of distant metastasis
    • Less than 10% of Hurthle cell carcinomas take up radioiodine
    • High tumor recurrence rate
    • High mortality rate – 30% mortality at 10 years
  • 8. Anaplastic Carcinoma
    • Increasingly rare
    • Arise within differentiated cancers
    • Pts > 60 years old with rapidly expanding neck mass
    • Local invasion very common at time of dx (FNA)
    • Surgery plays limited role given advanced stage at dx
    • Radiation and chemotherapy have not demonstrated any significant improvement in survival
    • Median survival ~ 4 - 6 months
  • 9. Medullary Thyroid Carcinoma
    • Originates from the parafollicular C cells
    • Elevation in calcitonin and CEA (50%)
    • 80% have sporadic MTC (unifocal), remainder have genetic component
    • 75% patients have LN metastasis at time of dx, 20% distant mets
  • 10. Medullary Thyroid Carcinoma
    • MEN IIA 
      • MTC (100%), pheo (40%), hyperparathyroidism (35%)
      • AD inheritance
      • Missense mutation of extracellular cysteine of RET
      • Surgery recommended before 6 years of age
    • MEN IIB 
      • MTC (100%), pheo (50%), mucosal ganglioneuromas (100%), marfanoid habitus
      • AD inheritance
      • Missense mutation of tyrosine kinase domain of RET
      • Surgery recommended in infancy
    • Familial MTC
  • 11. Lymphoma of the Thyroid
    • Usually non-Hodgkin’s B cell type
    • Pts with Hashimoto’s thyroiditis have 70-80 fold increase risk
    • Typically women > 70yo present with enlarging neck mass
    • FNA > 80% accuracy
    • Treatment includes XRT and chemotherapy
    • 5 year survival rates 50-70%
  • 12. 45 year old female presents to your office with a thyroid nodule. What questions will you ask her?
  • 13. History
    • Characteristics of nodule
    • Is the patient symptomatic?
      • Hyperthyroid/Hypothyroid
      • Compressive sxs
    • Family history  MEN endocrinopathies
    • Radiation exposure
  • 14. 45 year old female with thyroid nodule
    • Characteristics of nodule  found incidentally by PCP
    • Is the patient symptomatic?  No
      • Hyperthyroid/Hypothyroid
      • Compressive sxs
    • Family history  None
    • Radiation exposure  None
  • 15. Physical Exam
    • Size
    • Consistency of nodule, multiple or solitary
    • Fixed or mobile
    • Presence of cervical LAD
  • 16. Physical Exam
    • Solitary nodule
    • Mobile, not obviously adherent to adjacent structures
    • No cervical LAD
    • Normal voice
    • Otherwise well appearing
  • 17. Evaluating a thyroid nodule
    • Thyroid nodules are common, but less than 10% are malignant
    • History and PE
    • TSH level should be obtained during initial evaluation
      • If low, radioisotope study
      • If normal or high, then proceed to ultrasound
  • 18. Evaluating a thyroid nodule
    • What is the risk of a “hot” nodule on radioiodine scan being malignant?
    • Less than 1%
    • What about a “cold” nodule?
    • 15% – 20%
  • 19. Evaluating a thyroid nodule
    • Radioisotope studies may also be useful:
      • FNA reports “suspicious for follicular neoplasm” or “indeterminate”
      • Detecting neck metastasis
  • 20. Evaluating a thyroid nodule
    • What information will an ultrasound provide?
      • Number of nodules
      • Location and size of nodules
      • Cystic versus solid
  • 21. Evaluating a thyroid nodule
    • Which of the following are concerning findings on ultrasound?
      • Halo sign
      • Hypoechogenic
      • Calcifications
      • < 1cm
  • 22. Evaluating a thyroid nodule
    • Which of the following are concerning findings on ultrasound?
      • Halo sign
      • Hypoechogenic
      • Calcifications
      • < 1cm
  • 23. Evaluating a thyroid nodule
    • FNA is the most reliable and cost efficient way to determine malignant from benign lesion
    • 4 categories:
      • Malignant, benign, suspicious, indeterminate
    • Limitation of FNA:
      • Cannot distinguish benign follicular or Hurthle cell adenoma from malignancy – based upon presence or absence of capsular or vascular invasion
    • False negative rate < 5%
  • 24. 45 year old female with thyroid nodule
    • TSH level was normal
    • Underwent an ultrasound-guided FNA of the nodule, pathology revealed papillary carcinoma in a nodule measuring 2.5cm
  • 25. Management of Papillary Carcinoma
    • What surgical procedure would you offer her?
    • Near-total or total thyroidectomy is recommended if:
      • Tumor > 1-1.5cm
      • Contralateral nodules
      • Local or regional metastasis
      • + FHx in 1 st degree relative
      • + history of radiation exposure
      • Age >45 yo
    • Increased extent of surgery lowers recurrence rates and has improved survival in high-risk patients
  • 26. Management of Papillary Cancer
    • When is lobectomy an acceptable surgical procedure for FNA proven papillary cancer?
    • According to the American Thyroid Association Guidelines Taskforce, lobectomy with isthmusectomy may be sufficient treatment for microcarcinoma (  1cm), low-risk patients, intrathyroidal cancer without involvement of cervical LN
  • 27. Management of Papillary Cancer
    • Will you plan on performing a lymph node dissection?
    • A central compartment (Level VI) neck dissection should be considered
    • If nodal disease is evident clinically then a more extensive cervical lymphadenectomy should be performed
    • LN sampling not recommended
  • 28. Surgical Anatomy: Lymphatics
  • 29. Surgical Anatomy: Lymphatics
    • What are the LNs located superior to the thryoid gland in the midline called?
    • Delphian nodes
  • 30. 45 year old female with papillary carcinoma
    • Patient opted to have a total thyroidectomy and surgical specimen demonstrated unifocal disease with capsular invasion and negative LN. Does she have a favorable or unfavorable prognosis?
  • 31. Prognostic Risk Classification for Patients with Well-Differentiated Thyroid Cancer (AMES or AGES)
    • Low Risk High Risk
    • Age <40 years >40 years
    • Sex Female Male
    • Extent No local extension, Capsular invasion, extra-
    • intrathyroid, no caps thyroidal extension
    • invasion
    • Metastasis None Regional/distant
    • Size <2 cm >4 cm
    • Grade Well diff Poorly diff
  • 32. Management of Papillary Cancer
    • What further treatment is recommended?
    • TSH suppression therapy
    • Radioiodine ablation therapy
  • 33. 45 year old female with papillary carcinoma
    • She wants to know what her long-term survival is. What will you tell her?
    • ~ 90% at 10 years for papillary carcinoma
  • 34. 45 year old female with thyroid nodule
    • TSH level was normal
    • Underwent an ultrasound-guided FNA of the nodule, pathology suspicious for a follicular neoplasm
    • What is the risk that this is malignant?
    • Approximately 20%
    • What surgical procedure will you offer her?
  • 35. Management of FNA suspicious for follicular neoplasm
    • Lobectomy would be a reasonable surgical procedure, particularly in low-risk patient who prefers limited surgical intervention
    • Near-total or total thyroidectomy still recommended for high-risk patient and/or large tumor size
  • 36. Management of FNA suspicious for follicular neoplasm
    • Intra-operative frozen sections can be helpful in this scenario? True or false
    • False
  • 37. 45 year old female with thyroid nodule
    • You performed a lobectomy and the final pathology reveals Hurthle cell carcinoma
    • What further treatment do you recommend?
    • Completion thyroidectomy with central compartment LN dissection
    • TSH suppression therapy
  • 38. Post-operative radioiodine remnant ablation
    • To whom should it be offered?
    • Stages III and IV disease
    • Stage II disease in pts under age 45
    • Selected pts with Stage I
      • Multifocal disease
      • Nodal metastasis
      • Extrathyroidal extension
      • Vascular invasion
      • Aggressive histology
  • 39. TMN Classification for differentiated thyroid cancer
    • T1  2cm
    • T2 2-4cm
    • T3 >4cm, limited to thyroid
    • T4a Any size, invasion of SQ, trachea, esophagus, RLN
    • T4b Any size invasion of prevertebral fascia or encasing carotid/mediastinal vessels
    • N0 no nodes
    • N1a Level VI
    • N1b All other levels
    • Stages
    • Stage I T1, N0, M0
    • Stage II T2, N0, M0
    • Stage III T3, N0, M0
    • T1-3, N1a, M0
    • Stage IVA T4a, N0, M0
    • T4a, N1a, M0
    • T1-3, N1b, M0
    • Stage IVB T4b, any N, M0
    • Stage IVC Any T and N, M1
  • 40. 45 year old female with thyroid nodule
    • She asks what her overall 10 year survival will be with her diagnosis of Hurthle cell carcinoma?
    • ~70%
    • What if she had follicular carcinoma?
    • ~70%
  • 41. Recommendations for follow-up (differentiated cancers)
    • Thyroid cancer recurs in 20-40% patients, most commonly within the first 2 years
    • Thyroglobulin used as tumor marker checked every 6-12 months
    • Whole body scan may be useful in intermediate and high-risk patients 6-12 months after ablation
    • Ultrasound should be done 6-12 months after surgery, then annually for the next 3-5 years
  • 42. Management of recurrent and metastatic disease
    • Surgery mainstay of treatment for locoregional disease  radioiodine  radiation
    • Metastatic disease treated with radioiodine
      • Older patients with bony mets are less likely to respond to radioiodine and have poor prognosis
      • Pulm mets more radio responsive than bone mets
  • 43. 55 year old male presents to your office with MTC on FNA
    • Palpable thyroid nodule and cervical LN
    • Diarrhea and flushing
    • No FHx of MEN endocrinopathies
    • Calcitonin elevated, FNA reveals MTC
    • Any further tests that you should order?
    • Genetic testing
    • CT scan to see extent of disease
  • 44. 55 year old male presents to your office with MTC on FNA
    • What surgical procedure will you recommend to him?
    • Total thyroidectomy with LN dissection in Level VI and LN sampling in lateral regions (frozen sectioning intra-operatively)
  • 45. 55 year old male presents to your office with MTC on FNA
    • What do you want to check for before bringing him into the operating room?
    • Presence of a pheochromocytoma
  • 46. 55 year old male presents to your office with MTC on FNA
    • How would you handle the parathyroid glands?
    • Some recommend performing a total parathyroidectomy with autotransplantation in either the forearm or SCM
  • 47. 55 year old male presents to your office with MTC on FNA
    • Further treatment remains controversial but includes radiation therapy and chemotherapy
    • Surveillance using calcitonin levels
  • 48. Surgical Anatomy: Vasculature
  • 49. Surgical Anatomy: Vasculature and nerves
  • 50. Surgical Anatomy
    • What is the consequence of injurying the external branch of the superior laryngeal nerve?
    • Injury results in paralysis of the cricothyroid muscle
  • 51. Surgical Anatomy: Anatomical variations of the Right RLN
  • 52. Surgical Anatomy
    • What is the result of an injury to the recurrent laryngeal nerve?
      • Ipsilateral paralysis
      • Contralateral paralysis
  • 53. Surgical Anatomy
    • What is the result of an injury to the recurrent laryngeal nerve?
      • Ipsilateral paralysis
      • Contralateral paralysis
  • 54. Surgical Anatomy
    • What would you do if the tumor involved the RLN?
    • If vocal cord is paralyzed pre-operatively, then consider resecting the RLN along with specimen
    • If no vocal cord paralysis, dissect tumor off nerve
  • 55. Surgical Anatomy: The Parathyroids
  • 56. Surgical Anatomy: The Parathyroids
    • What are your options if the blood supply to the parathyroids has been compromised?
    • Implantation within the sternocleidomastoid muscle or forearm muscle for easy access