Comparison of Competitive and Depolarizing Blocking Agents No antagonism Transient reversal Effect of KCl or tetatnus on block Transient fasciculations None Initial excitatory effect Partial, persisting depolarization Elevated threshold to Ach; no depolarization Effect on motor end plate No antagonism Reverse Efect of cholinesterase inhibitors May be additive None/antagonistic Effect of previous decamethonium Antagonistic Additive Effect of previous d-tubocurarine Depolarizing Competitive
Dual Block by Depolarizing Agents C10: decamethonium; NEO: neostigmine; TC: tubocurarine NEO reversed the blockade by C10.
Systolic BP Systolic BP % Change in Systolic BP with d-Tubocurarine as a Function of Dose and Depth of Anesthesia Increasing Dose of d-tubocurarine Increasing Depth (% Halothane) 0.25% 0.5% 0.75% 6 mg/m 2 12 mg/m 2 18 mg/m 2
Influence of Type of Anesthetic on Enhancement of Neuromuscular Blockade By d-Tubocurarine
HR CO SVR MAP Hemodynamic Effects of d-Tubocurarine and Pancuronium