Orange Healthcare - Personalised Medicine


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Benjamin Sarda

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  • presentation title presentation title presentation title Introducing the three pillars. Distribution: Two thirds: 20% to 10% Health management: list the diseases (diabetes, cardiovascular disease, kidney failure, etc.) En 2011: one billion euros; it is expected to double within five years.
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  • presentation title The X Prize. $10 million to the first team to rapidly, accurately and economically sequence 100 whole human genomes The complete sequence of the human genome occupies about 1Gb.
  • presentation title The complete sequence of the human genome occupies about 1Gb.
  • presentation title The X Prize. $10 million to the first team to rapidly, accurately and economically sequence 100 whole human genomes The complete sequence of the human genome occupies about 1Gb.
  • Left : Hines Ward, Right : Troy Polamalu Other eg : H1N1 in France, patients decided not to follow OMS recommandation, and to skip vaccination Conclusion : Patient community duty, physician must be part of the buzz, etc
  • presentation title Patients like me : 100 000 patients in 2011, more than 500 diseases.
  • presentation title In 1985 and 1986 an epidemic of asthma hit Barcelona. The city’s researchers first turned to the usual suspects, such as air pollution, pollen and mould. But a series of telephone interviews with the sufferers pointed to a much more precise cause. All the attacks had occurred by the harbour, and at times when ships were unloading soya beans. The cause was clear: soya-bean dust. So was the solution: the installation of filters on the harbour’s silos. Stories of success, like that of Barcelona, are rare. Part of the reason for that lack of clarity is inadequate data on where and when attacks happen. But David Van Sickle, an epidemiologist and medical anthropologist who once worked for America’s Centres for Disease Control and Prevention (CDC), has come up with a solution. This is to use the asthma inhalers carried around routinely by patients to record the time and location of symptoms as they happen. To develop his idea, Dr Van Sickle left CDC and founded a company, Asthmapolis, which is based in Madison, Wisconsin. The result is Spiroscout, an inhaler with a built-in Global Positioning System locator and (in advanced models) a wireless link to the internet. Whenever someone uses the inhaler, it broadcasts the location and time to a central computer. Asthmapolis plots and analyses the data, and sends weekly reports to participating patients and their doctors summarising the observations and making recommendations. Over the past three years Dr Van Sickle has run two pilot studies to test the new tool. Both of these showed useful improvements in patients’ management and understanding of their disease. They have also resulted in him questioning some longstanding theories about asthma, including the ideas that symptoms occur primarily at home and that the affliction is more prevalent in urban areas than rural ones. If those insights are confirmed, they will change the way asthma is managed. Commercialisation is planned for the autumn.
  • presentation title Just like MRI, it’s a new way for healthcare.
  • Orange Healthcare - Personalised Medicine

    1. 1. Personalized medicine:some facts and a perspective Benjamin Sarda – Head of Marketing, Orange Healthcare
    2. 2. Agenda part 0 Orange Healthcare part 1 the evolution of personalized medicine part 2 down the road part 3 a prediction2
    3. 3. Orange Healthcare joining up healthcare  Orange helps modernize the healthcare infrastructure as well as healthcare systems as a whole, and equip healthcare facilities with communications solutions  we are convinced that the medicine of tomorrow is connected medicine in which the management of healthcare data and medical information play an essential role  at Orange Healthcare, we are using our expertise in communications to enable healthcare professionals to increase patient comfort and peace of mind3 Orange Healthcare - 2012
    4. 4. in 2012, Orange has solutions to offer in 3 areas services for remote healthcare preventive healthcare monitoring services professionals services professionals to professionals to patient professionals patients our services connect our services allow patients our tools allow individuals to infrastructure to improve to keep in touch with improve prevention by coordination, collaboration, healthcare professionals, managing their own health and information flow among so professionals can and well-being on a day-to- all the traditional players in provide high-quality care day basis the healthcare profession hosting and sharing of medical remote monitoring of cardiac drug authentication imaging arrhythmia4 Orange Healthcare – 2012 - 2012 Orange Healthcare
    5. 5. Our value chain is tightly linked with key partners:medical device manufacturers, health apps editors... Patients Partners Partners Medical Orange Health Healthcare Healthcare Applications ecosystem Devices Value Chain Global Health M2M, Integration Specific “Computin Internation , developmen g” al Helpdesk, ts (Security, (hosting) backbones services to portals) & Last mile end users Consulting, Integration Communication layer : voice and data transmission5
    6. 6. 1- The evolution of personalized medicine Today, personalized medicine is mainly about oncology Stakeholder concerns: Patients: more effective with fewer side effects Pharmas: reduce drug failures in late clinical trials Regulatory: value for money Today : over 50% of cancer drugs in development are targeted 6
    7. 7. 1- The evolution of personalized medicine The emergence of new technologies allows for a larger view of personalized medicine 1 “Big Data” Prevention 2 Enabling access to information Patient empowerment 3 Monitoring patients anytime, anywhere New ways of delivering care 7
    8. 8. 2- Down the road In a few years, DNA sequencing will be about $100 $100 000 000 Moore’s $10 000 000 Complete DNA law sequencing cost $1 000 000 $100 000 $10 000 $1 000 Jul 2002 Jul 2004 Jul 2006 Jul 2008 Jul 2010 Oct. 2011 8
    9. 9. 2- Down the road Predictive medicine for everyone. 9
    10. 10. 2- Down the road Personalized medicine in prevention: What are the advantages? The downside ? 2003 Today Tomorrow Human Genome Project International team Disease likelihood, $ 3 billion (US) adverse effects Targeted drugs, bespoke follow up Risk for payers: Risk for patients: “health dictatorships” What if I do not want to Competition between know ? countries. 57% of individuals at risk for Huntington’s Disease indicated an interest in testing before it was available. 16% took the test* 10 *Maat-Kievit et al. J Neurol Neurosurg Psychiatry 2000;69:579-583
    11. 11. 2- Down the road Personalized medicine in prevention: The downside…… How Super Bowl has made a $1,500 treatment (which costs $200) popular without any proof of efficiency 11
    12. 12. 2- Down the road Personalized medicine and patient empowerment The possibilities exist. What are the advantages? Medical imaging in general practice 2010 US: 68m X-rays, 42m MRI Patients generate data Fr: 50m (X-rays + MRI) with professionals, or alone Patient record The medical cloud Veteran Health Administration: 5.5m is up and running France: dossier pharma > 15m It is not just about raw data, but also corporate decision making tools 12
    13. 13. 2- Down the road Personalized medicine as new ways of delivering care Asthma A better follow-up for 300M people worldwide (5% the patient population), You’ve been using your what triggers asthma attack remains unclear inhaler twice as much as you did last month - is everything 1985: asthma epidemic hits ok? Barcelona. All attacks occurred near the harbour, A better when ships were unloading soya beans. understanding of the external causes You might want to avoid 2011: chips inside getting too close to that crop! asthma inhalers 13
    14. 14. 2- Down the road Personalized medicine: consequences of “Big Data” •Massive amounts of data •New kind of follow up, with new medical challenges •New kind of jobs 14
    15. 15. 3- a prediction Personalized medicine will require the end of two myths: the omniscient physician, and the patient-led revolution in healthcare Data will be available But does it fit an existing healthcare process ? Is there someone to monitor & interpret this data? Are physicians ready to use data collected by their patient? We will be facing two challenges  Over-expectation: omniscient physician  Be sure that healthcare pros are leading the way , 15
    16. 16. thank you16