Major technological advances in the last few decades have increased our knowledge of the role that genetics plays in occupational diseases.”“Combined with knowledge of other factors that contribute to occupational morbidity and mortality, genetic information will play an increasing role in preventing occupational disease.”“Understanding the role of genetic factors and their interaction with environmental/occupational exposures is important in occupational health and could lead to further prevention and control efforts, the identification of novel therapeutic targets and educational strategies for better management of work-related diseases.”
The body is just a systemCompliance Risk Management
This figure is also from the landmark study by P M Ricker and colleges discussed in the last slideTheir results showed that;“Of the 12 markers measured, high sensitive C-Reactive Protein, hs-CRP, was the strongest univariate predictor of CV events; the risk of events for women in the highest as compared with the lowest quartile for this marker was 4.4.”They also concluded that the greatest risk for Cardiovascular disease (CVD) outcomes was seen for people in the highest quartile for C- Reactive Protein and the total / HDL cholesterol ratio.Therefore the addition of the measurement of CRP to screening based on lipid levels may provide an improved method of identifying women at risk of CV events. PLEASE NOTE HOWEVER; The purpose of include these 2 figures is not to focus on disease states, such as CV events, but merely highlight the fact that inflammation processes via the inflammatory cytokines or proteins, such as IL-6 and CRP have a very significant influence on our health and performance.As you have repeatedly heard, the FitGenes focus is on helping people “maximise their potential for Healthy Living – Healthy Aging”.
DNA profiling is enabling personalized medicine. It is imperative that practitioners use the framework of the 12 week program to integrate a targeted and personalised intervention program, based upon the DNA profile, family medical history, personal medical history, symptoms and current lifestyle habits, and ensure the protocol will deliver the patient’s health goals and objectives.The treatment plan clearly identifies objectives and process for both the practitioner and the patient.
Genome-based Healthcare for the Workplace
Improving Health, Performance and Productivity
Personalised Genome-based Healthcare in the Workplace
Dr Paul Beaver - Director (Science), Co-founder
The Current Health Crisis
There are 3 trends that significantly
influence workplace health and
Influencing Workplace Health and Performance
Recent Australian Government data shows
1) Life Expectancy:
Increasing but Health Expectancy decreasing.
Men - last 18.6 years and women - last 20.7 years with disabilities.
2) Obesity Epidemic:
Australians overweight or obese
68% of men (over 7.3 million ) & 55% of women (over 6.0 million)
3) Ageing Population:
By 2020 approximately 20% of Australians will be over 65 years old
1 References available on request
The Current Health Crisis
Influencing Workplace Health and Performance
2. Exercise- lack of
3. Food- quantity & quality
5. Alcohol / drugs
6. Environmental factors- air, water
NOW the most important factor is:
7. Interaction of our genes with our lifestyle choices
Factors Contributing to Current Health Crisis
Importance of Gene and
The recent Federal Government report released in May 2009, titled
“Weighing it up – Obesity in Australia”, stated that:
1.Environmental and Lifestyle Factors
contribute about 30% to an individual‟s body weight, and;
2. Genetics contributes the other 70%
(Similarly, research indicates the ratio for Heart Health is approx. 50 % and 50%.)
Genetics in the Workplace*
Major technological advances in the last few decades have increased
our knowledge of the role that genetics plays in occupational diseases
Combined with knowledge of other factors that contribute to
occupational morbidity and mortality, genetic information will play an
increasing role in preventing occupational disease.
Understanding the role of genetic factors and their interaction with
environmental/occupational exposures is important in occupational
health and could lead to further prevention and control efforts, the
identification of novel therapeutic targets and educational strategies for
better management of work-related diseases.
*Recent On-line article from the Centers for Disease Control and Prevention
-National Institute for Occupational Health and Safety
,USA, http://www.cdc.gov/niosh/topics/genetics/ ,
Genetics in the Workplace
“In summary, the use of genetic
information in the workplace has the
potential to affect every worker in the
*Genetics in the Workplace - Implications for Occupational Safety and Health,
DEPARTMENT OF HEALTH AND HUMAN SERVICES, Centers for Disease Control and Prevention National
Institute for Occupational Safety and Health, NIOSH, 2010
Nutrigenetics and Nutrigenomics
Nutrigenomics – What is it?
Studies the interaction between our genes, diet and
It‟s true you can’t change your genes, HOWEVER,
you can compensate for their influence by making
the right nutritional, exercise and lifestyle choices.
The Fitgenes „Multi-disciplinary‟
CA Support Announced:
“Healthy Solutions Win Backing”
On 29 June 2012, Commercialisation Australia (CA) announced
another $9 million in funding to support 24 new participants and
extend additional funds to two existing participants on the
(Health Potential + Pre-disposition to Risk)
Nutrition, Exercise &
(identify potential for
health or risk)
Recommend Personalised Gene-matched
Nutrition, Exercise and Lifestyle
Fitgenes Health Program - Overview
Fitgenes 12 Week Program Outline
Program Item Baseline
DNA Profile Yes
Treatment Plan and
Yes Yes Yes Yes
Clinic Appointment Yes
Weight Loss Case
Practitioner - Sharon Palmer
> 6 years ago weighed 140 kgs.
> Has had significant weight loss in the past:
- Lost 60 kg: regained
- Lost 50 kg: regained
> Went to GP for weight loss:
- Put onto Optifast Shakes:
- 3 shakes per day
- No food at all for 10 months
> GP also put on drugs to increase metabolism and suppress appetite:
- Use for 3 months but couldn‟t tolerate.
- Caused anxiety and panic attacks.
- Had also used T3, but also stopped this as didn‟t like the effect.
Jenny‟s Weight Loss History
Jenny‟s Rebound Weight Gain
> When stopped the Optifast shakes went back to being careful with
> Regained 5 kgs per week, and ended back at starting weight.
> Was so unhappy she „wanted to die‟.
– GP recommended a gastric bypass but Jenny didn‟t want this.
– Decided to have a gastric sleeve. Done Feb 2007.
– Initially lost a lot of weight.
– Weight loss has now stopped and Jenny is beginning to gain
– She is afraid she will gain all her weight back again.
Follow up Follow up
Date 14/9/11 16/1/12 8/3/12
Patient Actual Age
Lost 14.81 yrs
First time younger than
Weight kg 85 kg 72 kg
-13 kg total
Never been this weight
Difference from ideal
Difference from ideal
Total loss -0.40kg
IntraCellular Fluid %
42.02 L 45.72 L 48.23L
ExtraCellular Fluid %
57.98 H 54.28 H 51.77 H
Cellular Fluid Balance:
(Ideal -20 to 0)
36.30 H 26.27 H
Aim F <80 M <94
Total loss of 21 cm
Total loss of 23 cm
Inflammation decreasing Inflammation
“Doing my Fitgenes DNA
profile has helped me gain
information that has helped
me on a number of levels.”
Jenny B. 2012
Firstly, I felt better about my previous
struggles, knowing there was an
underlying genetic reason for my obesity
and yo-yo weight gains. I felt better about
the fact that it had a root cause. I suppose
I could have felt powerless to do much
about it but instead it energised me to
fight against it. …..
Testimonial February 2012
› Doing my Fitgenes DNA profile has helped me gain information that has helped me on a number of
› Firstly, I felt better about my previous struggles, knowing there was an underlying genetic reason for
my obesity and yoyo weight gains. I felt better about the fact that it had a root cause. I suppose I
could have felt powerless to do much about it but instead it energised me to fight against it. I am
actually proud of myself for losing weight. My genetic profile would indicate this is very difficult for me,
and I am prone to rebound weight gain.
› It also encourages me to fight harder to not allow myself to regain. I don‟t think I can get away with
things anymore. Also, there was always a point in the past when I assumed I could eat normally. Now I
have much more information and it enables me to talk straight to myself.
› In food terms it has changed my whole way of eating. I found that I cannot tolerate a high intake of
saturated fats and my body is designed to store these. As a result, I do not generally eat meat or
animal fats like hard cheese. I love cheese and wine, I just don‟t eat the cheese any more. (I am still
working on the wine). It makes it much easier to maintain my weight loss. There are times when I do
eat them but very rarely. The point is I can now make an informed choice.
› Overall, I would say that this is the best decision I have made as it has given me information that has
helped me make sense of my struggles and gives me tools to make decisions for the future. I just can‟t
kid myself anymore as I know the truth!!!
Case Studies – High Blood Pressure
Client: A B C D
Age (years) 50 34 50 54
Gender Male Male Male Male
FT Program Start Date 24/02/2012 5/11/2011 23/11/2011 16/04/2010
FT Program Week # 1 5 1 9 1 12 1 6
Blood Pressure (BP) 155/99 1 130/85 130/80 2 120/65 183/84 3 117/77 190/110 140/80
Weight (Wt) Kg 106 101 124 108 - 4 - 82 76
Change in Wt 5 14 6
Waist Circumf. (WC) cm 119 114 111 98 - - - -
1. BP had been at 172/119 before starting the program
2. BP had been at 158/100 before starting the program
3. BP had been at 213/110 before starting the program
4 Weight Management was not a health goal for this client as his % body fat was in the superfit range