Common variable immunodeficiency is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that may cause infection. The main features that separate CVID from other immunodeficiencies are low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). Individuals with this condition develop more frequent infections, particularly in the sinuses, lungs, and digestive tract. CVID symptoms most commonly begin in early adulthood, but have been found in children as young as two years. Though some cases of CVID are caused by known genetic factors, the cause of most cases is unknown. CVID can sometimes be treated by "replacing" antibodies into the body; this treatment is called "immunoglobulin therapy". ORDR