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Cepravin   2007 q2 -  vet presentation MSD Salud Animal Salud Lechera
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Cepravin 2007 q2 - vet presentation MSD Salud Animal Salud Lechera


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MSD Salud Animal Salud Lechera

MSD Salud Animal Salud Lechera

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  • Contagious not as important, now environmental. E.coli is topical, but doesn’t have the impact of S.uberis on whole farm SCC….se next slides
  • Transcript

    • 1. 2007
    • 2. The current UK situation…
      • Increasing herd size
      • Increasing 305 day yields
      • Worsening cell counts
      • Longer calving intervals
      • Increasing average age at first
      • calving
      (NMR Data 2006)
    • 3. Cell counts are increasing (NMR Data 2006)
    • 4. Diagnosed Mastitis Pathogens (VIDA Data 2006)
    • 5. Most farms have mixed infections… 2/3 of these included both a Gram -ve and a Gram +ve organism That’s a total of 42% of all herds! (Farmfile Data 2004)
    • 6. … and of the farms with mixed infections …
    • 7. Farmfile Data - Conclusions
      • Most farms have multiple pathogens that cause mastitis
      • Many farms have BOTH Gram positive and Gram negative pathogens
      • These farms require broad spectrum dry cow therapy
    • 8. Studies confirm the benefits of a longer dry period
      • Milk yields were reduced for lactations following less than a 60 day dry period
      • (Makuza & McDaniel)
      • Studies where half udders were subjected to 30 or 70 day dry periods showed that
        • over the first 100 days of lactation 70 day dry periods produced 23% more milk than 30 day dry periods (Gulay et. al.)
    • 9. High risk of new dry cow infections during…
      • Involution
        • Intramammary pressure increases – widening of streak canal and teat orifice
        • Physical flushing out of bacteria stops
        • Teat hygiene measures cease
        • Milk fat and debris impair leucocyte function
    • 10.
      • Colostrogenesis
      • During the mid dry period the fully involuted udder is relatively resistant to bacterial infection. However, many of the resistance mechanisms are reversed during colostrogenesis.
        • Colostrum production increases intramammary pressure
        • Leucocyte concentration falls
        • The levels of natural bacterial inhibitors, such as lactoferrin, are reduced
      High risk of new udder infections during… Therefore, antibiotic cover is required throughout the dry period
    • 11. Cepravin delivers up to 10 weeks protection
      • Cepravin remains active for at least 10 weeks against major mastitis pathogens including:
        • S. aureus
        • S. uberis
        • S. dysgalactiae
        • A. pyogenes
      • Up to 5 weeks cover against E. coli
    • 12. Cepravin Continues to Perform EU sensitivity study 2000-2005
      • Major mastitis pathogens remain sensitive to cefalonium at MIC 90 levels which are achieved in the udder
      • Confirms 10 weeks activity vs
        • S. uberis
        • S. aureus
        • S. dysgalactiae
        • A. pyogenes
      • All tested strains of E.coli sensitive to
      • cefalonium
    • 13. Duration of activity…
      • Product LR provides up to 3 weeks cover for penicillin-sensitive organisms (NOAH Data Sheet)
      • Product CG provides up to 5 weeks cover
      • (Thomas et. al.)
      • Product OE has no activity against Gram –ve organisms (NOAH Data Sheet)
      • Cepravin provides up to 10 weeks cover against the most commonly diagnosed Gram +ve and Gram –ve pathogens
    • 14. Cepravin has been proven to speed up natural teat sealing (Williamson JH et al.) weeks 1 3 5 7 9 11 13
    • 15. Do teat sealants seal?
      • Recent trial, 232 cows ‘clean’ at drying off treated with internal sealant
      • 81 new infections with major mastitis pathogens isolated immediately post-calving
      • Gram +ve and Gram -ve bacteria isolated
        • 14% of these infections were E.coli
      (Huxley et al, 2002)
    • 16. New infections post teat sealant 11 E. coli 81 All major pathogens 11 Strep. other 11 Strep. uberis 2 Strep. dysgalactiae 9 Staph. aureus New infections Pathogen
    • 17. Teat sealants used alone
      • New infections arise in teats that have been internally sealed
      • Gram +ve and Gram -ve infections occur
      • If considering using antibiotic DCT as well
        • Effective cover against Gram +ve and
        • Gram –ve bacteria required
        • Ensure covers entire dry period
    • 18. Cepravin delivers broad-spectrum cover
      • Major Gram +ve pathogens
        • S. aureus
        • S. uberis
        • S. dysgalactiae
        • A. pyogenes
      • Gram –ve pathogens, including E. coli
    • 19. Cepravin– the only dry cow tube licensed to reduce cell counts (Cepravin data sheet)
    • 20. Summary:
      • Cepravin DC provides
        • Up to 10 weeks protection
        • Broad spectrum cover including E. coli
        • Earlier teat sealing
        • Proven ability to lower SCC
      • Proven activity against A. pyogenes , cause of Summer Mastitis
      • 43% of dry cow antibiotic treatments are Cepravin DC