e s t r um at e ® fa c t s , p ub l i s he d s t udi e sa n d fi e l d t r i a l dataEstrumate ProstaglandinConsistently O...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aEstrumate Prostaglandin Consistent...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aSeguin’s Work                     ...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aSeguin’s Work                     ...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aMartineau’s Work                  ...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aNew York Dairy Field Trial        ...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aCalifornia Dairy Field Trial      ...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aIdaho Dairy Field Trial           ...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aCanadian Work                     ...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aOregon Beef Herd Field Trial      ...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aFlorida Beef Herd Study           ...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aStage of Cycle Effects on Response...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aStage of Cycle Effects on Response...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aWhy Estrumate Is Superior to Lutal...
e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aReferences      EmEa, the European...
2006 estrumate us book
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2006 estrumate us book

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MSD Finca Productiva Reproduccion

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2006 estrumate us book

  1. 1. e s t r um at e ® fa c t s , p ub l i s he d s t udi e sa n d fi e l d t r i a l dataEstrumate ProstaglandinConsistently Outperforms Lutalyse ®Summary of Eight Studies
  2. 2. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aEstrumate Prostaglandin ConsistentlyOutperforms Lutalyse Summary Of Eight Studies ® • Half-life for EstrumatE prostaglandin is three hours compared to a few minutes for Lutalyse. EstrumatE prostaglandin lasts much longer 1 than Lutalyse. the sensitivity of the corpus luteum to prostaglandin injection increases progressively during the estrous cycle. 2 • EstrumatE prostaglandin is a more potent luteolytic agent than Lutalyse. 3 • EstrumatE prostaglandin quickly reduces progesterone levels and provides 4 a rapid estrus response. 5 • EstrumatE prostaglandin features a convenient 2-mL dose for heifers and cows. a 2-mL dose is easier to use and gives you confidence in EstrumatE prostaglandin’s performance.
  3. 3. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aSeguin’s Work 5 Dairy • Cows were treated on Day 8 of the estrous cycle. • Compared estrus response and conception rate by product. • Evaluated estrus response until Day 6 after injection. • Cows were artificially inseminated 12 hours after estrus was detected.
  4. 4. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aSeguin’s Work 5 (continued) Dairy r e sult s, e s t r ous r e sp onse by p r oduc t r e s u lt s , p e r c e n t a nim a l s in h e at Time to Estrus Estrumate ® Lutalyse ® Estrumate ® Lutalyse ® (n=62) (n=62) 48 hours* 37 27 48 hours post injection* 59.7% 43.5% 60 hours 17 21 60 hours post injection 87.0% 77.0% 72 hours 3 5 84 hours post injection 92.0% 85.0% 84 hours 0 0 156 hours post injection 96.8% 88.7% 96 hours 0 1 108 hours 1 0 r e s u lt s , c on c e p t ion r at e b y p r o du c t 120 hours 1 0 Estrumate ® Lutalyse ® 132 hours 0 0 (n=62) (n=62) 144 hours 1 1 Conception rate 62.5% 56.3% 156 hours 0 0 total responses 60/62 55/62 Response rate 96.8% 88.7% *p=0.07
  5. 5. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aMartineau’s Work 3 Dairy s t u dy c on du c t e d in c a n a di a n d a ir y op e r at ion s f r o m m ay 1, 19 9 3 t o ju n e 1, 19 9 4 • Lactating dairy cows and heifers having a corpus luteum determined by rectal palpation were randomly assigned to treatment groups. Estrumate ® Lutalyse ® Number cases 101 102 Conception rate 41.8% 33.7% Pregnancy rate 34.9% 29.3% *Differences between treatment groups not statistically significant.
  6. 6. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aNew York Dairy Field Trial 6 Dairy • Compared reproductive performance of • all cows were bred the following animals receiving Estrumate vs. Lutalyse. ® ® thursday between noon and 2:00 p.m. • Ovsynch protocol utilized. • Cows were pregnancy checked by the dairy’s consulting veterinarian • trial began November 2003 and was at day 32-46 after breeding. completed september 2004. b r e e din g p r o gr a m r e s u lt s * • the first tuesday after 45 days in milk, an Estrumate Lutalyse ® ® injection of prostaglandin, based on the Number cows/treatment 232 222 animals’ treatment group, was administered. First service conception rate 39% 34% • the following week on tuesday, the second service conception rate 43% 32% cows all received a Gnrh injection. • the following tuesday the cows received an injection of prostaglandin, based *Differences between treatment groups not statistically significant. on the animals’ treatment group.
  7. 7. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aCalifornia Dairy Field Trial 6 Dairy • Compared reproductive performance of e c ono mic s animals receiving Estrumate vs. Lutalyse. ® ® • For every 1% increase in pregnancy rate, • trial began January 2004 and was per cow profitability increases up to $17.00. completed November 2005. • Calculate the economic advantage • Cows received prostaglandin of Estrumate in your operation. at 50-100 days in milk. • Cows were pregnancy checked by the dairy’s consulting veterinarian at day 35-49 after breeding. r e s u lt s * Estrumate ® Lutalyse ® Number cows/treatment 1,555 1,491 *Differences between treatment First service conception rate 30.4% 29.9% groups not statistically significant.
  8. 8. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aIdaho Dairy Field Trial 6 Dairy • Compared reproductive performance of summary animals receiving EstrumatE vs. Lutalyse. ® Continued trends of superior EstrumatE • Injected products and bred performance in conception rates following an observed heat. two injections: 35.0% vs. 32.0% • study conducted in the fall/winter 2004. three injections: 30.0% vs. 28.0% r e s u lt s * 2 Injections 3 Injections Conception rate Conception rate 35.0% 30.0% Estrumate (39/111) (39/131) 32.0% 28.0% Lutalyse (38/119) (39/139) *Differences between treatment groups not statistically significant.
  9. 9. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aCanadian Work 7 Beef One injection to beef heifers, where CL was • Beef heifers were palpated for cyclicity palpated before injection* and randomly assigned to one of two prostaglandin treatments. Estrumate ® Lutalyse ® • two injections were given 11 days apart (n=56) (n=63) and heifers bred on estrus detection, First service Conception rate 61.0% 57.0% following each prostaglandin injection. Pregnancy rate 96.0% 87.0% • Heat detection and aI continued after synchronization for approximately one month. two injections given 11 days apart to cycling beef heifers* • at that time, red angus bulls were used for the remainder of the breeding season. Estrumate ® Lutalyse ® • Cows were artificially inseminated 12 hours (n=129) (n=126) after estrus was detected. Estrus 92.0% 86.0% Pregnancy rate 91.0% 83.0% *Differences between treatment groups not statistically significant.
  10. 10. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aOregon Beef Herd Field Trial 6 Beef • Compared reproductive performance of animals receiving Estrumate vs. Lutalyse. ® ® • two injections 11 days apart, with breeding 12 hours after estrus detected. • study conducted in summer 2004. r e s u lt s Estrumate ® Lutalyse ® P Value Heifer 39.6% 35.0% 0.2009 Conception rate (143/361) (130/371)
  11. 11. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aFlorida Beef Herd Study 8,9 Beef • Evaluated pregnancy rates to a timed aI results, conception r ates by products* program in Bos indicus x Bos taurus cows. EstrumatE: 41% (n=297) • used Gnrh, PG F2a and mGa. Lutalyse: 36% (n=297) • Cosynch hybrid program Day 0: Gnrh Day 1-7: mGa, 0.5 mg/head/day Day 7: EstrumatE or Lutalyse ® Day 10: timed aI plus Gnrh *Differences between treatment groups not statistically significant.
  12. 12. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aStage of Cycle Effects on Response toDifferent GnRH + Prostaglandin F2a Treatments 6 m at e r i a l s a n d m e t ho d s • three different PGF protocols injected seven days after GnrH. • Presynchronization with a two-dose modified protocol. – Lutalyse 25 mg – Lutalyse 12.5 mg (day 7 and 8) – Lutalyse 25 mg on D -14 ® – EstrumatE 0.5 mg – Lutalyse 12.5 mg on D -3 and D -2 • Blood samples collected before • Estrus detected with HeatWatch. injection and at every 48 hours until • GnrH injected in four different estrous response and/or ovulation. days of the estrous cycle. • ultrasound imaging. – Days 2, 5, 12, 18
  13. 13. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aStage of Cycle Effects on Response toDifferent GnRH + Prostaglandin F2a Treatments 6 Estrous response (%), CL regression (%) and Interval to Estrus of Different PGF Products Injected 7 Days after GnrH Injection 110% 95 Estrous response 5 days after PGF injection 100% 90 90% 90 Percentage of cows 95% Interval to Estrus (h) with CL regression 80% 81% Interval (hours) from PGF 70% 85 % Cows 74% injection to onset of estrus 60% 63% 50% 77 80 40% *Differences between treatment 30% 75 groups not statistically significant. 20% 10% 70 Lutalyse 25 mg ® Estrumate ®
  14. 14. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aWhy Estrumate Is Superior to Lutalyse • Cloprostenol sodium, the active Estrumate *® Lutalyse ** ® ingredient in EstrumatE, has a longer half-life than dinoprost tromethamine, Half-life 3 hours Extremely short (few minutes) the active ingredient in Lutalyse. ® almost completely • Cloprostenol is a more potent Not degraded by 15- cleared after one or Clearance hydroxy-dehydrogenase luteolytic agent than dinoprost. and 13,14-reductase two passages through the liver and/or lungs • Cloprostenol is not degraded by 15-hydroxydehydrogenase and 13,14-reductase. * EmEa, the European agency for the Evaluation of medicinal Products. Committee for Veterinary medicinal Products. Cloprostenol and r-Cloprostenol summary report, april 1997. ** EmEa, the European agency for the Evaluation of medicinal Products. Committee for Veterinary medicinal Products. Dinoprost, summary report, June 1997.
  15. 15. e s t r um at e ® fa c t s , p ub l i s he d s t udi e s a n d f i e l d t r i a l dat aReferences EmEa, the European agency for the Evaluation of medicinal Products. “Cloprostenol and r- 1 Cloprostenol.” summary report, april 1997. EmEa, the European agency for the Evaluation of medicinal Products. “Dinoprost.” summary report, 1 June 1997. 2 Berardinelli, J.G., et al. "Effect of prostaglandin dosage and stage of estrous cycle on the estrous response and corpus luteum function in beef heifers.” Theriogenology, 32: 301-314, 1989. 3 martineau, r. “Dinoprost Versus Cloprostenol: Does route of Injection modulate their Efficacy in Dairy Cattle?” The Bovine Practitioner, pp. 10-19, February 2003. 4 Hayashi, K., et al. "Changes in Prostaglandin secretion by the regressing Bovine Corp Luteum.” Elsevier – Prostaglandins & Other Lipid mediators. 70:339-349, 2003. 5 seguin, B., et al. “Cloprostenol and Dinoprost tromenthamine in Experimental and Field trials treating unobserved Estrus in Dairy Cows.” The Bovine Practitioner, pp. 85-90, November 1985. 6 Data on file at schering-Plough animal Health Corporation. Comparison of Estrumate and Lutalyse in Beef Heifers. Joint Federal Provincial 7 Demonstration Project at Douglas, manitoba, Canada 1981-1983. 8 Hiers, Ea. 2003 Florida Beef report, pp 77-79. 9 Hiers, Ea et al. Journal of Animal Science 81:830-835, 2003. Copyright © 2006, schering-Plough animal Health Corporation. all rights reserved. EstrumatE is a trademark of schering-Plough animal Health Corporation. LutaLysE is a registered trademark of Pfizer animal Health. sPaH-Est-48a
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