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thermo fisher  ED886123-7163-46F5-8387-5F57485F786B_FINAL09SHOW_III thermo fisher ED886123-7163-46F5-8387-5F57485F786B_FINAL09SHOW_III Presentation Transcript

  • Building on Our Industry Leadership The world leader in serving science Marc N. Casper Chief Operating Officer Ian D. Jardine, PhD Vice President, Global R&D Pittcon 2009 Press Conference March 9, 2009
  • The World Leader in Serving Science We are the leading provider of analytical instruments, equipment, reagents and consumables, software and services for research, analysis, discovery and diagnostics. Leading Brands Size and Scale Unmatched Capabilities Complete portfolio $10.5 billion in revenues World-class technologies 34,000+ employees in 40 countries Commercial and service strength Serving 350,000 customers in 150 countries Fortune 300 company 2
  • A Mission We are Proud of Safer Healthier Cleaner We enable our customers to make the world healthier, cleaner and safer 3
  • Our Strengths Global industry leadership Ability to continuously invest in growth opportunities Key competitive • Developing innovative products advantages • Invested $250 million in R&D in 2008 Broad portfolio • • Strengthening commercial capabilities Diverse customer base • • Extending our channel reach Global reach • • Expanding in growing markets Strong balance sheet • • Focus on China and India Excellent track record of financial performance A partner you can count on 4
  • A Compelling Value Proposition Targeted Innovation We deliver unmatched scientific productivity through our innovative technologies, services and systems. Scientific Productivity Extended Business Partner 5
  • Thermo Scientific: New Products for Today’s Demands Better analytical Greater efficiency Voice of Customer performance and productivity Speed and sensitivity Integrated workflows Precise quantitation Data management Ease of use Broad applications Advanced technologies Laboratory for non-experts Industrial and field Sustainability Energy efficiency Reduced solvent usage Differentiated in performance and productivity 6
  • Fisher Scientific: One Source, Infinite Solutions Providing customers with a growing portfolio of convenient sourcing and service options 7
  • Helping our Customers Achieve their Goals Pharmaceutical Customer Targeted Laboratory Business Innovation Productivity Partner Equipment standardization Consolidated ordering Scientific collaboration Methods development Standard operating E-commerce platform procedures and validation Application-based Third-party sourcing workflows Global logistics network Outsourced services Data management and asset management 8
  • Expanding our Capabilities with Strategic Acquisitions Equipment Instrumentation Chemito Technologies: FiberLite: Carbon fiber centrifuge rotors Routine analytical instruments Consumables and Reagents Customer Channels Open Biosystems: RNAi Hucoa Erloss, Afora, Bonsai: Affinity Bioreagents: Antibodies Extends European channels 9
  • The World Leader in Serving Science 10
  • Pittcon 2009: New Products for Key Applications Sample Analysis Sample Preparation Data Interpretation 11
  • Pittcon 2009: New Products for Sample Preparation Sample Analysis Sample Preparation Data Interpretation 12
  • Pittcon 2009: New Products for Sample Preparation Hamilton Distinction II Green Lab Meters Furniture Hamilton Infinity Fume Hood Electrodes siRNA, shRNA, miRNA Bioreagents Protein Catalogs 13
  • Pittcon 2009: New Products for Sample Analysis Sample Analysis Sample Preparation Data Interpretation 14
  • New Thermo Scientific Products for Sample Analysis Industrial & Drug Discovery Petroleum & Environmental & Basic Product Testing & Development Chemical Food Screening Research TSQ Vantage™ LCMS Access Max™ Transcend TLX™ Accela Exactive™ LCMS ™ NanoDrop 2000/2000c UV/Vis Titan 4000™ Niton XRF GOLDD™ NSX Analyzer R Arena™ Chemistry Analyzer A range of innovations, from research to routine testing 15
  • Revolutionary New Micro UV-Vis Capability Basic Research Customer Needs: Thermo Scientific NanoDrop Quick, easy, accurate UV-Vis analysis Low or no sample prep, reduced solvents More sensitivity Our Response: Unique “all-in-one” Spectrophotometer Ideal for DNA, RNA, proteins, cell cultures Patent-pending combination of micro-volume pedestal and built-in cuvette capability 200X concentration vs. conventional specs Broad wavelength range Kinetics capability Dramatic advances in UV-Vis performance 16
  • Leading-Edge Performance Thermo Scientific NanoDrop 2000c Key Specifications Broad: concentration range (ng/µl) 0.4 – 15,000 ng/ul (dsDNA) Broad: wavelength range (nm) 190 - 840 Accurate: absorbance accuracy and precision 2% and .002 Fast: measurement time (secs) <5 (pedestal) Fast: measurement time (secs) <3 (cuvette) Versatile: number of path lengths 7 Advanced: custom methods capability yes Small: minimum sample size (µl) 0.5 Compact: footprint (cm) 14 x 20 17
  • Intuitive, Clear, Easy-to-Use Software 18
  • Highest Triple Quad Sensitivity Drug Discovery & Development Customer Needs: Thermo Scientific TSQ Vantage Mass Spec Greater sensitivity (S/N) for Hesi II probe ultralow-level quantitation Precision and reproducibility Multiple analytes per run New Our Response: sweep 10X more sensitivity than cap any other triple quad 1,000 SRMs per second and 3,000 timed SRMs per LC run Full peptide, protein quantitation TSQ series 2.0.0 software Patented S-lens Unmatched signal-to-noise performance exceeds customer expectations 19
  • TSQ Vantage Beats Existing Systems Sample Name: quot;Std 0.01quot; Sample ID: quot;quot; File: quot;08305rlc39a PPT Evap 8Mar08 4.wiffquot; Peak Name: quot;Dextromethorphan-d3quot; Mass(es): quot;275.2/171.2 amuquot; RT: 0.98 - 3.96 Comment: quot;quot; Annotation: quot;quot; Sample Index: 31 NL: 1.35E4 RT: 3.04 Sample Type: Standard 2.68 100 Concentration: 0.0100 TIC F: + c ESI Calculated Conc: 0.0109 740 Acq. Date: 3/9/2008 SRMms2 275.180 Acq. Time: 2:11:48 PM 720 95 [171.049-171.051] Modified: No Proc. Algorithm: IntelliQuan - MQII 700 MS ICIS Noise Percentage: 93 Base. Sub. Window: 1.00 min 680 competitor 90 tt-test_mix_124 Peak-Split. Factor: 2 Report Largest Peak: No 660 Min. Peak Height: 200.00 cps Min. Peak Width: 4.00 sec Smoothing Width: 3 points 85 640 RT Window: 30.0 sec Expected RT: 2.72 min 620 Use Relative RT: No 80 Int. Type: Base To Base 600 Retention Time: 2.69 min Area: 1892.34 counts 580 Height: 5.72e+002 cps 75 Start Time: 2.63 min Dextromethorphan-d3 560 End Time: 2.74 min 540 70 In Rat Plasma 520 500 65 (LLOQ at 0.01 ng/mL) TSQ Vantage 480 460 60 Relative Abundance 440 420 55 >10X LOQ 400 In t e n s it y , c p s 50 380 360 better than 45 340 2.59 3.23 320 40 competitor’s 300 2.82 280 3.07 2.78 35 260 3.41 best efforts 2.85 3.13 2.95 3.58 240 2.40 3.34 30 220 200 25 180 160 20 140 15 120 100 10 80 60 5 40 20 0 0 1.0 1.5 2.0 2.5 3.0 3.5 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Time, min Time (min) Unsurpassed triple quad performance 20
  • High Performance for Routine Applications Environmental & Food Screening Customer Needs: Thermo Scientific Workflow Solution Advanced screening for routine applications Higher sensitivity and throughput Streamlined method development Our Response: Simultaneous quantitation and structural confirmation Fast +/- switching for high- speed multi-component trace analysis 3000 timed SRMs per LC run New TraceFinder software Quantum TraceFinder™ Software Accela UHPLC Access MAX™ ™ The value choice for routine food safety, pharma, environmental and clinical applications 21
  • Accela-Access Max Performance in Pesticide Screening Tricyclazole Carbaryl Carbofuran Diuron Siduron Daimuron Carpropamine Time (minutes) Complex multi-residue pesticide analysis (10 ppt) in <3 minutes 22
  • End-to-End Workflow for Multiplexing LC/MS/MS Drug Discovery & Development Customer Needs: Thermo Scientific Workflow Solution In-line sample extraction End-to-end workflow analysis Our Response: Doubles sample analysis throughput Increases detection limits New high performance ultralow dead volume LC pumps Fully integrated software for multiplexed LC-MS ™ Accela UHPLC™ TSQ Vantage Transcend TLX™ High-throughput benchmark for clinical and drug analysis 23
  • A Revolution in LC-MS Environmental & Food Screening Customer Needs: Thermo Scientific Exactive Cost effective target ID and compound identification Higher throughput analysis with advanced mass accuracy Easy-to-use workflow enabler and productivity platform Our Response: Full scan MS with HCD scanning Walk-up compound identification • Pesticides, metabolites, tox screening New quantitation capabilities Accela UHPLC™ Powerful Pathfinder™ software Speed, spectra, ultrahigh resolution, superb accurate mass, and precise quantitation all in an affordable bench-top system 24
  • The Value of Reproducible High Mass Accuracy Total of about 110 pesticides Component Elemental Composition [M+H] Error [ppm] (each ~ 250 ug/L) Propoxur C11H15NO3 210.1125 1.10 in very complex horse feed matrix Chlortoluron C10H13ClN2O 213.0789 1.20 Metribuzin C8H14N4OS 215.0961 2.00 Atrazine C8H14ClN5 216.1011 2.50 Diuron C9H10Cl2N2O 233.0243 2.00 Carbetamide C12H16N2O3 237.1234 1.20 Pirimicarb C11H18N4O2 239.1503 6.50 Clomazone C12H14ClNO2 240.0786 0.10 Cyanazine C9H13ClN6 241.0963 0.90 Linuron C9H10Cl2N2O2 249.0192 1.20 Thiacloprid C10H9ClN4S 253.0309 0.70 Triadimefon C14H16ClN3O2 294.1004 0.30 Paclobutrazol C15H20ClN3O 294.1368 1.40 Fenthion- sulfoxide Fast chromatography (<15mins) C10H15O4PS2 295.0222 2.00 Triadimenol Exactive running at 15,000 resolution C14H18ClN3O2 296.1161 0.20 Imazalil C14H14Cl2N2O 297.0556 1.70 Spiroxamine C18H35NO2 298.2741 1.20 All molecular weight masses within 2.5 ppm except… 25
  • The Value of Reproducible High Mass Accuracy Total of about 110 pesticides Component Elemental Composition [M+H] Error [ppm] (each ~ 250 ug/L) Propoxur C11H15NO3 210.1125 1.10 in very complex horse feed matrix Chlortoluron C10H13ClN2O 213.0789 1.20 Metribuzin C8H14N4OS 215.0961 2.00 Atrazine C8H14ClN5 216.1011 2.50 Diuron C9H10Cl2N2O 233.0243 2.00 Carbetamide C12H16N2O3 237.1234 1.20 6.50 Pirimicarb C11H18N4O2 239.1503 6.50 Clomazone C12H14ClNO2 240.0786 0.10 Pirimicarb Cyanazine C9H13ClN6 241.0963 0.90 Linuron C9H10Cl2N2O2 249.0192 1.20 Thiacloprid C10H9ClN4S 253.0309 0.70 Triadimefon C14H16ClN3O2 294.1004 0.30 Paclobutrazol C15H20ClN3O 294.1368 1.40 Fenthion- Unusually high error of 6.5 ppm sulfoxide C10H15O4PS2 295.0222 2.00 Re-analyze @ higher resolution of 80,000 Triadimenol C14H18ClN3O2 296.1161 0.20 Imazalil C14H14Cl2N2O 297.0556 1.70 Spiroxamine C18H35NO2 298.2741 1.20 Only Orbitrap technology allows this level of confidence 26
  • The world leader in serving science
  • The Value of High Mass Accuracy and Ultrahigh Resolution The Case for Exactive 100% A mixture of >100 pesticides, Detected compounds ppm 10 250 mycotoxins and veterinary 45% drugs at different concentration 99% levels in horse feed matrix 50 analyzed at two resolution 32% settings utilizing full scan accurate mass measurements 93% 250 10 (+/- 2ppm) 11% 0 20 40 60 80 100 100k % Detected 10K 10K resolution can’t detect known chemicals The power of 100K resolution Vastly superior analytical results with Orbitrap performance 28
  • The Value of High Mass Accuracy and Ultrahigh Resolution – Quantitation Concentration ranging from 0.2 ppb to 500 ppb Lowest Data point Dextrorphan profile with internal +/- 5 ppm standard 0.5 - 500 pg on-column 29
  • New Pathfinder Screening Software for Exactive Drug Discovery & Development Thermo Scientific Pathfinder Enabling the right workflow for the right user Experienced user Walk-up user Developed methods significantly streamline analysis Links into other software: • Thermo Scientific ToxID • Thermo Scientific Xcalibur Reports Pathfinder leverages full instrument capabilities 30
  • Orbitrap Technology for Routine Screening Applications Thermo Scientific Exactive Exactive™ will displace TOFs and QTOFs! 31
  • Superior Total NSX Analysis in a Small Footprint Petroleum & Chemical Customer Needs: Thermo Scientific Easy sample introduction TITAN 4000 NSX Analyzer Simple operation Increased analysis speed and sensitivity Our Response: Total nitrogen and total sulfur (TN/TS) analysis in <2 minutes Up to 60% reduction in bench space New nebulizing injection technique with high efficiency folded combustion tube NSX visual software EST Analytical Booth 1816 New capability for QC with increased productivity and lower operating costs for petrochemical and refinery industries 32
  • Next-Generation Portable XRF Elemental Analysis Industrial & Product Testing Customer Needs: Thermo Scientific Niton XL3t GOLDD Speed and sensitivity Portable and field rugged Identify multiple elements Other Thermo Scientific Real time data and simple Technology Niton XL3t GOLDD software interface Samples Our Response: 10x faster than conventional detectors 3x more precise than traditional silicon drift detectors Smaller Area Detector Large Area Proprietary GOLDDTM Large Area Detector Drift Detector Light element detection without helium or vacuum purging Breakthrough lab-quality performance in a handheld detector 33
  • “Clinical Chemistry” Analyzer for Non-clinical Labs Industrial & Product Testing Customer Needs: Thermo Scientific Arena Analyzer Easy and rapid automated methods Walk-away analysis Single system for multiple applications Our Response: Fast and efficient analysis in an advanced all-in-one system • Colorimetric and enzymatic applications • 45 reagent positions • Wavelength range 340 to 880 nm • Automatic barcode ID Accurate QC and analysis for pharma, agricultural, food • Example: Asparagine + glucose = potential acrylamide formation Sample throughput up to 600 tests per hour 34
  • Pittcon 2009: New Data Interpretation Solutions Sample Analysis Sample Preparation Data Interpretation 35
  • Pittcon 2009: New Data Interpretation Solutions Pathfinder TraceFinder Connects Enterprise Insights OMNIC Specta on Raman 36
  • Pittcon 2009: New Data Interpretation Solutions 0001110101010010010110101001010100101010100011010010101011010101010101010101010101010110101010101010 Maximize customer ROI from previous software investments 37
  • A Mission We are Proud of Safer Healthier Cleaner Environmental & Food Safety Pharma & Biotech Industrial Screening Quantitation Portability Confirmation Speed Speed Throughput Selectivity Sensitivity Ease of use Data management Robustness We enable our customers to make the world healthier, cleaner and safer 38
  • See it All! Information Mass Spectrometry Chromatography Molecular Spectroscopy and Chromatography Consumables Fisherbrand and Fisher Scientific products Nucleus LIMS, COS and Elemental Analysis Chemicals Spectroscopy Software HandheldXRF Analyzers Mass Spectrometry and Chromatography Water Purification Life Science Discrete Photometric Blue Crew Analyzers Sample Particle Technology Chromatography Preparation Laboratory Furniture and Fume Hoods Elemental Analysis UV-Visible Fisherbrand and Spectroscopy and Fluorescence Micro/Analytical Water Analysis Instruments Fisher Scientific products Technologies TRAM 39
  • Your Passport to Scientific Innovation Visit Thermo Scientific Booth 1432 Information Mass Spectrometry Chromatography Molecular Spectroscopy and Chromatography Consumables LIMS, COS and Elemental Analysis Spectroscopy Software HandheldXRF Analyzers Mass Spectrometry and Chromatography Water Purification Discrete Photometric Analyzers Particle Technology Laboratory Furniture and Fume Hoods Elemental Analysis UV-Visible and Fluorescence Water Analysis Instruments 40