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thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
thermo fisher  BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509
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thermo fisher BE83EA55-53AE-4224-AA31-E1B6E6FB41A4_UBSWestCoastLifeScienceBusTour32509

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  • 1. UBS West Coast Life Science Bus Tour The world leader in serving science San Jose, CA March 25, 2009
  • 2. Agenda Company Overview Kenneth Apicerno, Vice President, Investor Relations Technology Overview Ian Jardine Ph.D., Vice President, Global Research & Development Factory Tour Mark Chatfield, High Performance Liquid Chromatography (HPLC) Cell Manager 2
  • 3. Company Snapshot $10.5 billion in revenue 34,000 employees in 40 countries 350,000 customers 150 countries served #269 on Fortune 500 Clear industry leadership 3
  • 4. An Attractive Profile… Global Reach Market Strength Balanced Mix Asia, ROW Services Healthcare 13% 16% 22% Europe Life Science 26% Consumables 46% Instruments North America 49% Environmental, & Equipment 61% Industrial 30% & Safety 32% 5% Software …to meet diverse needs of global customers 4
  • 5. Two Distinct Business Segments Analytical Laboratory Products Technologies Segment and Services Segment Innovative technologies Providing customers geared toward the easy access to routine scientist and engineer laboratory products and services Focused on providing 41% 59% integrated workflows Focused on complete product offerings and Growth platforms: outsourced services • Analytical Instruments Growth platforms: • Specialty Diagnostics • Laboratory Products • Biosciences • Customer Channels • Biopharma Services Unmatched combination of technology breadth and purchasing convenience 5
  • 6. Analytical Technologies at Glance Specialty Diagnostics Analytical Instruments Biosciences Revenue: $1.3B Revenue: $2.5B Revenue: $0.7B Microbiology Scientific Instruments Immunoassay Life Science Research Environmental Instruments Molecular Diagnostics Bioprocess Production Process Instruments Anatomical Pathology Laboratory Chemicals Key Capabilities Key Capabilities Key Capabilities Instruments and software: Integrated workflow solutions for High-end reagents for life science highly specialized diagnostic research: • Mass spectrometry tests: • RNAi technologies • Chromatography • Drugs of abuse testing • Proteomics workflows • Molecular spectroscopy • MRSA infection High content screening kits, cellular • Elemental analysis • Cancer detection protein pathways, cell culture • LIMS and lab software products • Organ transplantation Moving technologies outside Leader in disposable bioprocess • Genetic testing the laboratory products for biotech manufacturing Revenue numbers before inter-company eliminations 6
  • 7. Laboratory Products and Services at Glance Customer Channels Biopharma Services Laboratory Products Revenue: $0.7B Revenue: $1.9B Revenue: $4.3B Laboratory Equipment Research Catalog Clinical Trials Logistics Laboratory Consumables Healthcare Catalog Analytical Services Laboratory Workstations Safety Catalog Key Capabilities Key Capabilities Key Capabilities Equipment: Unparalleled customer access Logistics services for clinical trials: • Sample preparation Research: World leading resource • Package, label, ship, store for lab equipment and • Separation Biological specimen archiving and consumables management • Controlled environment Healthcare: Premier diagnostic test Controlled drug storage and Liquid handling solutions catalog for hospitals, reference distribution Plastic and glass consumables labs and physicians’ offices Laboratory furniture and design Safety: Occupational health and safety products Revenue numbers before inter-company eliminations 7
  • 8. Agenda Company Overview Kenneth Apicerno, Vice President, Investor Relations Technology Overview Ian Jardine Ph.D., Vice President, Global Research & Development Factory Tour Mark Chatfield, High Performance Liquid Chromatography (HPLC) Cell Manager 8
  • 9. Healthcare Funding in the News Recovery & Reinvestment Act of 2009 (Stimulus Bill) • $10.4B one-time boost to NIH budget • $3B one-time boost to National Science Foundation Obama’s Current Budget Proposal • $6B one-time increase in NIH funding for cancer research • $1B increase to 2009 NIH budget (now $30.3B) • $1B to FDA to support food safety efforts Increased opportunities in healthcare 9
  • 10. Stem Cell Research Stem Cell Research is aimed at regenerating damaged tissues such as bone loss, nerve damage and replacement of dysfunctional cells Opportunity to treat diseases such as Alzheimer’s, Parkinson’s, Type 1 Diabetes and blood cancers Current administration expected to open up federal funding in the U.S. (included within stimulus package) Over $14b of U.S. investment expected over next ten years from state and private funding and expected to grow at 9% through 2015 Stem cell research promises to fill gaps where current methods fall short 10
  • 11. Stem Cell Research - Integrated Workflow Solutions Cell Lines Offering qualified culture ware, media and controlled environment that stem cells need in order to grow and multiply in a predictable way Technology to allow researchers to completely monitor, control and analyze stem cell growth Detection technology to ensure the Media Culture Ware quality of the final cell type, whether for therapeutics or for drug development Cell Imaging Key elements combined to assure stability and reproducibility 11
  • 12. Protein Research Proteins: basic components of all living cells and regulate how our bodies function Scientists working diligently to identify proteins • i.e.: ~10,000 proteins in our blood, and only about 3,000 can be detected today Understanding of proteins is critical for developing effective drug treatments Identifying the difference in proteins and protein levels in one patient versus another • Leading to personalized medicine and companion diagnostics Biomarker identification to enable the development of better diagnostic tests Protein biomarkers are key indicators of disease 12
  • 13. Protein Research – Mass Spectrometry Mass spectrometry is the instrument of choice to identify protein biomarkers Speed, resolution and accuracy are all improving rapidly Offering scientists complete workflow solutions … instruments, reagents, consumables and software Accelerating Time to Identify 1 Protein 2004 2006 2008 Next Before 1990 1 Every 3/10ths 1 Every 3/100ths 1 Every 1 Every 1 Every 30 seconds of a second of a second 3 seconds Year Thermo Fisher Scientific is leading the way in advancing protein science 13
  • 14. RNAi Technology RNA interference (RNAi) silences a gene and prevents that gene from producing its protein product • Nobel Prize winning technology developed in 1998 Research opportunity: Scientists are able to independently manipulate genes and evaluate the consequences to cells by silencing certain genes Therapeutic opportunity: Scientists are able to silence a gene and identify those gene products that are suitable as drug targets – they can now target “cancer” causing genes RNAi research advancing drug discovery 14
  • 15. RNAi Technology – Reagents and Services Industry leading products Pre-designed libraries of silencing reagents (siRNA, shRNA, and miRNA) Screening and profiling services for researchers mRNA and protein detection reagents Custom reagents for RNAi research Automated RNAi screening Integrated instrumentation and robotics for cell growth and analysis Performs high throughput screens using RNAi based reagents Standardizes process to maximize efficiency RNAi discovery services Provides RNAi-based high-throughput screening and analysis Conducting whole genome wide screens that help identify drug target Most comprehensive portfolio of RNAi-based reagents and services 15
  • 16. Pittcon 2009: New Products for Key Applications Sample Analysis Sample Preparation Data Interpretation 16
  • 17. Pittcon 2009: New Products for Sample Preparation Hamilton Distinction II Green Lab Meters Furniture Hamilton Infinity Fume Hood Electrodes siRNA, shRNA, miRNA Bioreagents Protein Catalogs 17
  • 18. New Thermo Scientific Products for Sample Analysis Industrial & Drug Discovery Petroleum & Environmental & Basic Product Testing & Development Chemical Food Screening Research TSQ Vantage™ LCMS Transcend TLX™ Access Max™ Accela Exactive™ LCMS NanoDrop™ 2000/2000c UV/Vis Titan 4000™ Niton XRF GOLDD™ R NSX Analyzer Arena™ Chemistry Analyzer A range of innovations, from research to routine testing 18
  • 19. The Value of High Mass Accuracy and Ultrahigh Resolution The Case for Exactive 100% A mixture of >100 pesticides, Detected compounds ppm 10 250 mycotoxins and veterinary 45% drugs at different concentration 99% levels in horse feed matrix 50 analyzed at two resolution 32% settings utilizing full scan accurate mass measurements 93% 250 10 (+/- 2ppm) 11% 0 20 40 60 80 100 Orbitrap 100k % Detected ToF 10K 10K resolution can’t detect known chemicals The power of 100K resolution Vastly superior analytical results with Orbitrap performance 19
  • 20. Orbitrap Technology for Routine Screening Applications Thermo Scientific Exactive TM Exactive will displace ToFs and QToFs! 20
  • 21. Pittcon 2009: New Data Interpretation Solutions Pathfinder TraceFinder Connects Enterprise Insights OMNIC Specta on Raman 21
  • 22. The World Leader in Serving Science 22
  • 23. Agenda Company Overview Kenneth Apicerno, Vice President, Investor Relations Technology Overview Ian Jardine Ph.D., Vice President, Global Research & Development Factory Tour Mark Chatfield, High Performance Liquid Chromatography (HPLC) Cell Manager 23
  • 24. San Jose LC/MS Products LTQ-ETD Triple Quads 3D and Linear Ion-traps LTQ Orbitrap Surveyor HPLC LTQ FTMS Accela UHPLC 24
  • 25. The World Leader in Serving Science We are the leading provider of analytical instruments, equipment, reagents and consumables, software and services for research, analysis, discovery and diagnostics. Thank you! 25

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