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monsanto 08-23-05

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  • 1. Soybean Breeding at Monsanto • Overview of Soybean Breeding • High Yielding, Diverse Germplasm Pool • Screening Capabilities and Markers • Roundup Ready™ 2nd Generation • Food Traits • Comprehensive Approach to Soy Improvements
  • 2. Soy Breeding is a Key Component of Our Success: Integration of Conventional Breeding, Breeding Technology, Integrated Pipeline Biotechnology, & Crop Analytics Objectives Enhance germplasm competitiveness Germplasm Resources Outstanding germplasm key to delivering value added traits Superior Yield Composition • Disease • Protein resistance • Oil Key Drivers • Yield stability Top yielding varieties Biotechnology Increased genetic gain through • RR2G & Yield Breeding Technology germplasm & technology • Food & Feed Traits • Marker Ass’ted Breeding • Markers for Key Traits High value opportunities in food & feed • Chromosome mapping Crop Analytics Pipeline support • HighThroughput • Essential for Marker Development Soy varieties with increased value • Higher yields • Improved consumer uses • Improvements in feed efficiency Increased value for Monsanto and our stakeholders
  • 3. 2005 North America Soybean Breeding •Glyndon Testing & Purity • Redwood Falls • Guelph • Janesville • Ames • Beaman • Findlay • Bloomington • Oxford • Stonington • Galena • Haubstadt • Marion • Stuttgart • Mt Olive Each station positioned to cover 5 million acres Typical station: 1 Breeder + 2-4 RA’s Global Soybean Breeding North America Variety Development Northern Region Central Region Southern Region
  • 4. Soybean Breeding at Monsanto: Excellent Germplasm from Multiple, Complementary Sources MonSoy Brazil High Yield First Line Asgrow Canada Food Elite Varieties in NA & SA Yield Germplasm Providers Defensive traits DeKalb High Yields Hartz Yield Complementary Southern US Midwestern US Food Elite Soy World Class Germplasm Pool Varieties w/ Value Added Traits University Industry Public Sources Collaborations Collaborations USDA, AVRDC Disease, Diversity Germplasm Diversity Disease, SCN, Diversity Experienced, Dedicated Breeding Staff Outstanding Germplasm 15 Variety Development Breeders in N. America Yield from multiple sources in 3 Breeders for South America North & South America 2 Trait Breeders Pest tolerance for Yield Stability 4 Pathology/Nematology Experts Useful variability for protein & oil 9 Leads with avg 15 years industry experience quality and quantity Breeding Tech expertise Aggressive development of markers for food, feed, and agronomic traits
  • 5. Plant Breeding Improvement for Soybeans DNA markers improve the efficiency of plant breeding procedures DNA markers improve the efficiency of plant breeding procedures Goals Goals 45 •• Identify what genes 40 Identify what genes control agronomic control agronomic 35 traits US Grain Yield (Bu/Acre) traits 30 •• Implement new Implement new breeding procedures 25 breeding procedures that improve our that improve our 20 ability to select for ability to select for these genes 15 these genes •• Increase the rate of Increase the rate of 10 genetic gain in our genetic gain in our 5 breeding programs breeding programs 0 1920 1930 1940 1950 1960 1970 1980 1990 2000 Year
  • 6. Soybean Relative Maturity Mon Soybean RM 0 1 2 3 4 5 6 7 8
  • 7. Biotic and Abiotic Stresses Vary Across the Soy Belt; Diverse Germplasm, Hi Throughput Screening, and Markers are the Foundation for Success R RM* Brown Root White Iron Soy Stem Phytop Root Stem Knot Mold Cyst Defic Canker Rot Rot Nema Nema 00-0 +++ ++++ +++ +++++ +++ - - 1-2 ++++ +++ ++++ +++++ ++++ - - 3 +++ - ++++ +++++ +++++ + + 4-5 + - + +++ +++++ +++++ +++ 6-8 - - ++ +++++ +++++ +++++ Scale: +++++ = severe, +++ = moderate, + = minor RM = Relative Maturity
  • 8. Broad Approach for Diseases, Nematodes, Insects & Nutritional Stresses Provides Yield Stability • Breeding and Breeding Tech Provide Solutions for Stresses that Can Limit Yield – Understand & prioritize key stresses by market – Field and/or greenhouse screens for important stresses – Automation to increase capacity – Continually search for new genes – Develop markers for useful genes – Integrated approach across Breeding, Breeding Tech, Biotech, Tech Development – Prioritized application of markers – Key partnerships with public institutions
  • 9. Multiple Approaches to Identify Solutions for Asian Soybean Rust • Monsanto Approach Map Rpp genes – – Utilize markers – Stack & evaluate major genes – Evaluate Soy Germplasm for new sources – Validate screening protocols and establish differential lines – Full operations of GC/GH screening facilities in St. Louis and GH in Brazil – Field screens in US and Brazil – Confirm USDA phenotypic scores in FT. Detrick, MD • Identify immune PI accessions Acquire & screen Map genes & Stack genes germplasm develop markers Biotech solutions
  • 10. Ag Challenge: Delivering Better Herbicide Tolerance & Increased Yields in Soybeans Roundup RReady2Yield® Soybeans Conventional Compared with RRSB, this Breeding New Technology will deliver better yield due to: Genomics Molecular Breeding Improved Tolerance Up to Breeding / Biotechnology +5 bu Breeding Technology New Event Yield estimates based on average yields of 64 bushels obtained in 2004. Lower yielding environments may not see the same level of yield increase Discovery Phase 1 Phase 3 Phase 4 Phase 2 Launch Proof of Concept Adv. Development Pre-Launch Pre- Early Development
  • 11. Rich Pipeline of Soybean Products with Improved Food Uses Progressive improvements in Oil Near Term Composition Pursue commercialization of germplasm Linoleic Oleic Sats Linolenic derived soy quality traits for near term 18:2 18:1 18:0 / 16:0 18:3 Standard profit opportunity, and development of Soybean business model – Develop and enhance strategic relationships, Low Lin and generate demand with food industry and supply chain to maximize value Mid Oleic – Oil composition + Low Lin – Improved Soy Protein Zero Sat + MO + LL Long Term Soy Protein: Improved flavor profile Continue development of oil composition improvements to ensure strong position on 16.0 14.0 Off- Flavor Type B soy trait business long term 12.0 Commodity – Multiple new traits with processing and 10.0 Soy health benefits 8.0 6.0 4.0 Improved 2.0 Soy 0.0 0.0 10.0 20.0 30.0 40.0 50.0 Off-Flavors Type A
  • 12. Low Linolenic Acid Improved Soybeans for Food Benefits: • Cost competitive, widely available trans free oil that doesn’t compromise taste or increase saturated fat • A more stable soy oil requiring less hydrogenation; reduce/eliminate trans fats. 2005 technical milestones • Successful launch of AG2421V and AG2321V • Rich Pipeline of new products to advanced stage testing • Marker utilization for multiple traits 2006 technical milestones • More commercial varieties • Continued yield improvements • Expanded area of adaptation
  • 13. Zero Sat + Mid Oleic + Low Lin Provides the Next Generation of Improvements Product Concept: Biotech soybean with broad industry appeal that achieves reduced Sats, low linolenic, and mid oleic levels. Ideal for cooking and salad, frying segments of the oil market. Benefits: Compositional change results in healthier oil (lower sats, mid oleic – reduced cardiovascular risk) with improved functionality (low lin, mid oleic – enhanced flavor from improved stability, prolonged shelf life.) 2005 Technical Milestones: Identify events that meet target composition, Commodity Roundup® tolerance, other selection criteria Zero Sat + Soy MO + LL Percent of Soy Oil Composition Linolenic 2006 Technical Milestones: Successful US field trials for most Linoleic promising transgenic events Key Challenges for Breeding: Initiate crosses with Vistive™ as soon as Oleic possible Saturates
  • 14. Benefits of High β-Conglycinin Soy Protein in Food HBC less binding of off-flavors Lower affinity for 25 Bound 2 pentyl pyridine Glycinin (moles/mole protein) odors, 20 15 creates 10 balanced β-conglycinin 5 flavors. 0 0.3 0.6 0.9 1.3 1.6 1.8 2.1 2 pentyl pyridine (mM) Highly soluble Soymilk protein sedimentation* Soymilk protein sedimentation* in beverages, ________________________ ________________________ creating HBC soymilk: 2% sediment HBC soymilk: 2% sediment smooth mouth Control soymilk: 15% sediment Control soymilk: 15% sediment feel *3 wk storage *3 wk storage
  • 15. Fully Integrated Approach: High Yielding Germplasm, Multi-faceted Approach to Traits, Screening Capabilities, and Markers Genomics Conventional Breeding Molecular Breeding Crop Analytics Chemistry

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