DESENSIBILIZE NANO P, WITH THE EXCLUSIVE NANO P TECHNOLOGY Desensibilize Nano P is a bifunctional paste developed to treat tooth hypersensitivity effectively and durably and to remineralize the dental structure.

1. YOU SOLVING
THE PROBLEMS
OF YOUR PATIENTS.
THE PROFESSIONAL TREATMENT
FOR HYPERSENTIVITY.
CONTAINS NANO-
HYDROXYAPATITE
Desensitizing and
Remineralizing Paste
YOU SOLVING

2. DENTIN
HYPERSENTIVITY
Efficiency and longevity
of the treatment
The nanoparticles of hydroxyapatite restore the
microstructure, the chemical composition of the teeth and
their functionality.
How does the pain occur?
Heat, cold and citric food, sweets, air and pressure are
stimuli that may cause the movement of fluids in the
dentin tubules, increasing the pressure inside of them,
which stimulates the nerves inside the tooth, resulting in
the pain.
Gingival recession
How Desensibilize
Nano P obliterates the tubules?
The nanoparticles of hydroxyapatite are deposited in
the dentin tubules, obliterating them, which difficult the
access of the external stimuli to the pulp and eliminates
the painful symptoms.
Nano-hydroxyapatite
Efficiency and longevity
of the treatment
The obliteration of the tubules is potentialized/stabilized
by the action of the saliva on the nanoparticles of
hydroxyapatite. Such obliteration remains intact even after
the exposure to acids.
Action of the saliva
How Desensibilize
Nano P remineralizes?
The nanoparticles of hydroxyapatite penetrate in the tooth,
integrating in it, and acting as a system of replacement and
release of calcium and phosphates ions, with acid resistance
similar to the hydroxyapatite of the natural tooth.
Microcracks/porosities in the enamel
Remineralizing action
DENTINDENTINDENTINDENTINDENTIN
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TOOTH REMINERALIZING

3. ADVANTAGES OF THE
NANO P TECHNOLOGY
Desensibilize Nano P is a bifunctional paste developed to treat tooth
hypersensitivity effectively and durably and to remineralize the dental
structure.
Desensibilize Nano P contains the exclusive Nano P technology, based on nanostructured
calcium phosphate in the form of nanoparticles of hydroxyapatite, which work in a
biocompatible way in the obliteration of the exposed dentin tubules, in the enamel
microcracks and in the remineralization of the dental structure, restoring the microstructure,
the chemical composition and the functionality of the tooth.
The nanoparticles of hydroxyapatite present a higher bioactivity,
due to its small diameter and its morphology which increases its
superficial area. In addition, its capacity of hydration and wetability
allow it to release ions calcium and phosphates to the tooth in the
adequate concentrations and speeds. This way, the presence
of the nano-hydroxyapatite confers differentiated and innovative
properties to the Desensibilize Nano P.
The desensitizing and remineralizing effects of Desensibilize
Nano P are potentialized through time by the action of the saliva
on the nanoparticles of hydroxyapatite contained in the product.
It acts promoting the adhesion between the nanoparticles and
their integration in the tooth.
Nano P is the innovative technology of nanoparticles of calcium
phosphate, which aims to bring bioactivity to the dental materials.
IT CONTAINS NANOPARTICLES
OF HYDROXYAPATITE, THE SAME
MINERAL THAT COMPOSES THE TOOTH
1
RELEASE OF CALCIUM
AND PHOSPHATES5
BIOCOMPATIBILITY2
RESISTENCE
TO SOLUBILITY6
BIOACTIVITY3
EFFECTIVENESS
AND LONGEVITY7
EXCELLENT PENETRATION IN THE
DENTIN TUBULES AND IN THE
ENAMEL MICROCRACKS
4
PROVED
TECHNOLOGY8
DESENSIBILIZE NANO P,
WITH THE EXCLUSIVE
NANO P TECHNOLOGY
WHAT IS THE NANO P TECHNOLOGY?
superficial area. In addition, its capacity of hydration and wetability
allow it to release ions calcium and phosphates to the tooth in the
on the nanoparticles of hydroxyapatite contained in the product.on the nanoparticles of hydroxyapatite contained in the product.on the nanoparticles of hydroxyapatite contained in the product.

4. Desensibilize Nano P is a high performance paste,
for professional use, indicated to:
treatment of hypersensitivity;
prevention of carious lesions in high risk patients;
help in the prevention of the tooth wear by erosion and abrasion;
remineralization of white spot lesions, dental decalcification, pre and post whitening treatment.
1 syringe with 3 g of product and 5 application tips.1 syringe with 3 g of product and 5 application tips.
INDICATIONS
PRESENTATION
EFFECTIVE AND LONG-LASTING TREATMENT

5. DESENSITIZATION
BY OBLITERATION
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BY OBLITERATION
DESENSITIZATION
BY OBLITERATION
SEE HOW IT WORKS: the new Desensibilize Nano P contains the new Nano P technology,
based on nanoparticles of hydroxyapatite. Its desensitizing performance happens
through two mechanisms:
PHYSICAL EFFECT: for being nanometric, the hydroxyapatite
penetrates more easily in the dentin tubules and
in the enamel microcracks, which difficult the
access of external stimuli that cause pain.
CHEMICAL EFFECT: the presence of potassium nitrate
potentializes the desensitization by the depolarization of nerve fibers;
the presence of fluoride complements such desensitization effect.
Opened dentin tubules BEFORE the treatment
with the Desensibilize Nano P, enabling
the sensitivity by the exposure to acids, to
heat/cold, to air, to touch.
The obliteration of the dentin tubules
remains INTACT even AFTER
THE EXPOSURE TO ACIDS.
Dentin tubules CLOSED after the
treatment with Desensibilize Nano P,
blocking the diffusion of the
pain-causing stimuli.
The obliteration of the dentin tubules
remains INTACT even AFTER
THE BRUSHING WEAR.
1
2
21
3 4
Nano-hydroxyapatite
+ saliva: desensitization
with resistance
to the acid dissolution
and to the brushing
wear.

6. Desensitizing action of the Desensibilize Nano P throughout the treatment
for the teeth that present initial severe or average (moderate) hypersensitivity.
Courtesy of Dra. Constanza Odebrecht and partners of the Vale do Itajaí University – SC, Brazil.
Relief of 80% of
the sensitivity after
the first application
and of 90% after the
second application.
Medium 4,16%
Severe
12,5%
%oftheteethineachlevelofsensitivity
Beginning
Beginning
Immediately
after the
1st
application
Immediately
after the
1st
application
Immediately
after the
2nd
application
Immediately
after the
2nd
application
Severe
100%
24 teeth
Severe
25%
0
100
Medium
54,16%
Light 8,33%
Light 62,5%
Null 12,5%
Null
20,83%
%oftheteethineachlevelofsensitivity
Medium
100%
19 teeth
Medium
21,05%
Medium 10,52%
0
100
Light
68,42%
Light
57,89%
Null 10,52%
Null
31,57%
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
IS CLINICALLY PROVEN
Clinical studies show that Desensibilize Nano P promotes:
RELIEF of the sensitivity IMMEDIATELY after the sole application of the product,
and such effect is POTENTIALIZED THROUGHOUT THE FIRST 48 HOURS
BY THE ACTION OF THE SALIVA ON THE NANOPARTICLES OF HYDROXYAPATITE;
EFFECTIVE and LONG-LASTING TREATMENT of the sensitivity.
EFFECTIVE AND LONG-LASTING TREATMENTEFFECTIVE AND LONG-LASTING TREATMENTEFFECTIVE AND LONG-LASTING TREATMENTEFFECTIVE AND LONG-LASTING TREATMENTEFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
IS CLINICALLY PROVEN
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
IS CLINICALLY PROVEN
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
IS CLINICALLY PROVEN
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
IS CLINICALLY PROVEN
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
IS CLINICALLY PROVEN
EFFECTIVE AND LONG-LASTING TREATMENT
OF THE TOOTH SENSITIVITY
IS CLINICALLY PROVEN
1
2

7. EFFECTIVE REMINERALIZING
ACTION
EFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZING
ACTION
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
ACTION
EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
ACTION
EFFECTIVE REMINERALIZING
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EFFECTIVE REMINERALIZING
ACTION
EFFECTIVE REMINERALIZING
ACTION
EFFECTIVE REMINERALIZING
ACTION
EFFECTIVE REMINERALIZING
ACTION
EFFECTIVE REMINERALIZING
ACTION
EFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZING
Remineralizing potential of Desensibilize Nano P on the surface of bovine enamel affected by
artificial caries lesion, submitted to the pH cycling (des- and remineralization) for seven days.
Different letters show statistic differences (p<0.05).
c
Recoveryofenamel’shardness(%)
c c
b,c
b
a
Control CPP-ACP Fluoride in Gel Fluoride
Varnish
FluorCare (FGM) Desensibilize
Nano P (FGM)
0
20
40
60
80
100
The remineralizing action of the Desensibilize Nano P occurs through two mechanisms:
PHYSICAL EFFECT: the nanoparticles of hydroxyapatite penetrate in the
porosities and enamel microcracks, easily integrating itself to the tooth, wich
is also comprised by hydroxyapatite. They repair their deficiencies, functionally
imitating it, acting as a system for the release of calcium and phosphate ions,
essential for the maintenance of the mineral balance of the tooth
in the demineralization conditions.
CHEMICAL EFFECT: the presence of 9,000 ppm of fluoride inhibits the
cariogenic activity of the bacteria and prevents the demineralization.
SEE HOW IT WORKS:
Lab studies show that Desensibilize Nano P promotes:
RECOVERY of 70% of the HARDNESS of the enamel affected by caries.
THE MAXIMUM EFFECT can already be noticed between the 2nd
and the 3rd
applications of
the product.
THE remineralizing EFFECT is POTENTIALIZED throughout the days by THE ACTION
OF THE SALIVA on the nanoparticles of hydroxyapatite.
EFFECTIVE AND LONG-LASTING REMINERALIZATION.
Recovery of 70% of the hardness
1
1
2
3
2
4
c c c
b,c
b
a

8. Wear of the bovine (µm) enamel structure (a) and dentin (b) after the erosive and abrasive
demineralization, during five days. Different letters indicate statistical difference (p<0.05).
Data given by Souza-e-Silva CM, Moron BM CAB, Magalhães AC, Buzalaf MAR, from Bauru Odontology
University – USP, Brazil.
Wearoftheenamel’sstructure(μm)
b
a a
Enamel
Desensibilize
Nano P
(FGM)
Desensibilize
Nano P
(FGM)
Mi Paste Plus
(GC America)
Control
0
1
2
3
4
5
6
Wearofthedentin’sstructure(μm)
b
b
a
Dentin
Mi Paste Plus
(GC America)
Control
0
1
2
3
4
5
6
7
8
9
PHYSICAL EFFECT: the nanoparticles of hydroxyapatite penetrate in the enamel porosity and
microcracks, and also in the dentin, easily integrating itself to the tooth and acting as a system for
the release of calcium and phosphate ions in the conditions of erosive demineralization and abrasion.
CHEMICAL EFFECT: the presence of 9,000 ppm prevents the demineralization.
PREVENTION OF THE TOOTH WEAR BY EROSION AND ABRASION.
SEE HOW IT WORKS:
Its action in the prevention of the tooth erosion and of the abrasion occurs through two mechanisms:
LAB STUDIES SHOW THAT DESENSIBILIZE NANO P IS EFFECTIVE IN THE
1
2
PREVENTION OF THE TOOTH WEAR
BY EROSION AND ABRASION

9. STEP BY STEP
For more information, check the technical
profile available to download on our website.
In case of doubts, check out technical
support: contato@fgm.ind.br or by the
telephone number +55 47 3441 6100.
Dispense the product in a sterile Dappen pot and apply it
on the tooth surface, with a micro-applicator (Cavibrush –
FGM), or apply it directly on the tooth surface, with an
application tip.
Clean the surface of the tooth and
perform the relative isolation. If
necessary, conduct previous prophylaxis.
1
Remove the excess of the product with
dry or slightly humid cotton pellet.
Instruct the patient not to eat or
drink for 30 minutes.
5
Leave the product resting
for 5 minutes.
With a felt disk adapted in low rotation
with low speed (Diamond Flex – FGM),
friction the product during 10 seconds.
3
4
2

10. Why the application of the Desensibilize Nano P brings more benefits to the
remineralization process when compared to the application of other conventional Fluoride-
based products?
When a Fluoride-based conventional product is applied on the tooth surface, there is
the formation of calcium fluoride CaF2
on the surface. Such CaF2
is initially stabilized by
proteins and saliva phosphates in neutral pH. However, when the pH falls during acid
challenges, the CaF2
is dissolved, releasing Ca2
and F, which will effectively contribute for
the reorganization of the hydroxyapatite crystals of the tooth in fluorapatite, which can, then,
actuate in a stable manner in the protection of the tooth against cavities. When we apply the
Desensibilize Nano P on the surface of the tooth, we are offering nano- hydroxyapatite for
it and, as we know, the hydroxyapatite is the organized crystal form of calcium phosphate,
which composes the natural tooth, stable to the dissolution. This way, when we apply
the Desensibilize Nano P, we already offer to the tooth a little bit of itself, facilitating the
interaction between the tooth and the product, increasing the probability of formation of
fluorapatite, amplifying the remineralizing potential of the product. In addition, as the nano-
hydroxyapatite contained in the Desensibilize Nano P is highly resistant to dissolution, when it
deposits itself on the tooth, it shall protect the hydroxyapatite of the tooth against dissolution.
In average, how many sessions with the product are necessary to promote the
remineralization of the teeth?
Lab studies indicate that, after two applications of the Desensibilize Nano P its maximum
remineralizing effect can already be observed. Based on these studies, for a better safety of
the clinical protocol of application of the product, we recommend 3 to 4 applications of the
Desensibilize Nano P when the purpose is the remineralization of the tooth surface.
QUESTIONS AND ANSWERS
1
In average, how many sessions with the product are necessary to promote the
desensitization of the teeth?
The number of sessions may vary, but clinical studies performed (check technical profile)
show that an average of 3 sessions is enough for the efficient and long-lasting treatment of
the tooth sensitivity.
3
2

11. The Desensibilize Nano P is effective in the prevention of the tooth hypersensitivity related
to the teeth whitening?
So far, there aren’t conclusive data that indicate that the application of the Desensibilize
Nano P is effective in the prevention of the hypersensitivity related to the teeth whitening.
However, the application of the product after the whitening may contribute for the
remineralization of the enamel surface, and also amplify the sensation of
the whitening, in promoting the flattening of the tooth surface.
The application of the Desensibilize Nano P before the teeth whitening may harm the
whitening process?
As the Desensibilize Nano P is comprised by nano- hydroxyapatite, which is the main
constituent of the tooth enamel, the application of the product does not interfere in the
whitening process. On the contrary, we may have a complementation of the whitening
sensation, by the fact that the product may promote the flattening of the tooth surface.
As it is a product with nanoparticles, could it present any risk for the patient
in case of ingestion?
Lab studies with cell culture show that the nanoparticles of hydroxyapatite contained in
the Desensibilize Nano P are not toxic for the cells, which brings safety in a situation
of ingestion of the product. Another factor that brings safety to the application of the
Desensibilize Nano P is the fact it releases calcium and phosphate ions when it is
solubilized, and such ions are already regulated (they are part of) by the metabolism of
the individual. The most important care related to high dosages of the Desensibilize
Nano P shall be in relation to the presence of the fluoride, which, if ingested in
high quantities, may be toxic. Desensibilize Nano P contains 9,000 ppmF and,
for this reason, it is only indicated for professional use.
4
5
6

12. DENTIN
HYPERSENSITIVITY?
EFFECTIVE AND LONG-LASTING TREATMENT.
Your patient will thank you.
Desensitizing and Remineralizing Agent
HOW THE PAIN HAPPENS?
Heat, cold and citric food, sweets, air
and pressure are stimuli that may cause
the movement of fluids in the dentin
tubules, increasing the pressure inside of
them, which stimulates the nerves inside
the tooth, resulting in the pain.
+55 47 3441 6100 | www.fgm.ind.br | twitter.com/fgmwhiteness | youtube.com/fgmprodutosodonto | contato@fgm.ind.br
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