YOU SOLVING
THE PROBLEMS
OF YOUR PATIENTS.
THE PROFESSIONAL TREATMENT
FOR HYPERSENTIVITY.
CONTAINS NANO-
HYDROXYAPATITE
De...
DENTIN
HYPERSENTIVITY
Efficiency and longevity
of the treatment
The nanoparticles of hydroxyapatite restore the
microstruc...
ADVANTAGES OF THE
NANO P TECHNOLOGY
Desensibilize Nano P is a bifunctional paste developed to treat tooth
hypersensitivity...
Desensibilize Nano P is a high performance paste,
for professional use, indicated to:
treatment of hypersensitivity;
preve...
DESENSITIZATION
BY OBLITERATION
DESENSITIZATIONDESENSITIZATIONDESENSITIZATIONDESENSITIZATIONDESENSITIZATION
BY OBLITERATIO...
Desensitizing action of the Desensibilize Nano P throughout the treatment
for the teeth that present initial severe or ave...
EFFECTIVE REMINERALIZING
ACTION
EFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERA...
Wear of the bovine (µm) enamel structure (a) and dentin (b) after the erosive and abrasive
demineralization, during five d...
STEP BY STEP
For more information, check the technical
profile available to download on our website.
In case of doubts, che...
Why the application of the Desensibilize Nano P brings more benefits to the
remineralization process when compared to the ...
The Desensibilize Nano P is effective in the prevention of the tooth hypersensitivity related
to the teeth whitening?
So f...
DENTIN
HYPERSENSITIVITY?
EFFECTIVE AND LONG-LASTING TREATMENT.
Your patient will thank you.
Desensitizing and Remineralizi...
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Folder Comercial_English. Desensibilize NanoP. Desensitizing and Remineralizing Paste

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DESENSIBILIZE NANO P, WITH THE EXCLUSIVE NANO P TECHNOLOGY
Desensibilize Nano P is a bifunctional paste developed to treat tooth hypersensitivity effectively and durably and to remineralize the dental structure.

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Folder Comercial_English. Desensibilize NanoP. Desensitizing and Remineralizing Paste

  1. 1. YOU SOLVING THE PROBLEMS OF YOUR PATIENTS. THE PROFESSIONAL TREATMENT FOR HYPERSENTIVITY. CONTAINS NANO- HYDROXYAPATITE Desensitizing and Remineralizing Paste YOU SOLVING
  2. 2. DENTIN HYPERSENTIVITY Efficiency and longevity of the treatment The nanoparticles of hydroxyapatite restore the microstructure, the chemical composition of the teeth and their functionality. How does the pain occur? Heat, cold and citric food, sweets, air and pressure are stimuli that may cause the movement of fluids in the dentin tubules, increasing the pressure inside of them, which stimulates the nerves inside the tooth, resulting in the pain. Gingival recession How Desensibilize Nano P obliterates the tubules? The nanoparticles of hydroxyapatite are deposited in the dentin tubules, obliterating them, which difficult the access of the external stimuli to the pulp and eliminates the painful symptoms. Nano-hydroxyapatite Efficiency and longevity of the treatment The obliteration of the tubules is potentialized/stabilized by the action of the saliva on the nanoparticles of hydroxyapatite. Such obliteration remains intact even after the exposure to acids. Action of the saliva How Desensibilize Nano P remineralizes? The nanoparticles of hydroxyapatite penetrate in the tooth, integrating in it, and acting as a system of replacement and release of calcium and phosphates ions, with acid resistance similar to the hydroxyapatite of the natural tooth. Microcracks/porosities in the enamel Remineralizing action DENTINDENTINDENTINDENTINDENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITY DENTIN HYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITYHYPERSENTIVITY TOOTH REMINERALIZING
  3. 3. ADVANTAGES OF THE NANO P TECHNOLOGY Desensibilize Nano P is a bifunctional paste developed to treat tooth hypersensitivity effectively and durably and to remineralize the dental structure. Desensibilize Nano P contains the exclusive Nano P technology, based on nanostructured calcium phosphate in the form of nanoparticles of hydroxyapatite, which work in a biocompatible way in the obliteration of the exposed dentin tubules, in the enamel microcracks and in the remineralization of the dental structure, restoring the microstructure, the chemical composition and the functionality of the tooth. The nanoparticles of hydroxyapatite present a higher bioactivity, due to its small diameter and its morphology which increases its superficial area. In addition, its capacity of hydration and wetability allow it to release ions calcium and phosphates to the tooth in the adequate concentrations and speeds. This way, the presence of the nano-hydroxyapatite confers differentiated and innovative properties to the Desensibilize Nano P. The desensitizing and remineralizing effects of Desensibilize Nano P are potentialized through time by the action of the saliva on the nanoparticles of hydroxyapatite contained in the product. It acts promoting the adhesion between the nanoparticles and their integration in the tooth. Nano P is the innovative technology of nanoparticles of calcium phosphate, which aims to bring bioactivity to the dental materials. IT CONTAINS NANOPARTICLES OF HYDROXYAPATITE, THE SAME MINERAL THAT COMPOSES THE TOOTH 1 RELEASE OF CALCIUM AND PHOSPHATES5 BIOCOMPATIBILITY2 RESISTENCE TO SOLUBILITY6 BIOACTIVITY3 EFFECTIVENESS AND LONGEVITY7 EXCELLENT PENETRATION IN THE DENTIN TUBULES AND IN THE ENAMEL MICROCRACKS 4 PROVED TECHNOLOGY8 DESENSIBILIZE NANO P, WITH THE EXCLUSIVE NANO P TECHNOLOGY WHAT IS THE NANO P TECHNOLOGY? superficial area. In addition, its capacity of hydration and wetability allow it to release ions calcium and phosphates to the tooth in the on the nanoparticles of hydroxyapatite contained in the product.on the nanoparticles of hydroxyapatite contained in the product.on the nanoparticles of hydroxyapatite contained in the product.
  4. 4. Desensibilize Nano P is a high performance paste, for professional use, indicated to: treatment of hypersensitivity; prevention of carious lesions in high risk patients; help in the prevention of the tooth wear by erosion and abrasion; remineralization of white spot lesions, dental decalcification, pre and post whitening treatment. 1 syringe with 3 g of product and 5 application tips.1 syringe with 3 g of product and 5 application tips. INDICATIONS PRESENTATION EFFECTIVE AND LONG-LASTING TREATMENT
  5. 5. DESENSITIZATION BY OBLITERATION DESENSITIZATIONDESENSITIZATIONDESENSITIZATIONDESENSITIZATIONDESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION DESENSITIZATION BY OBLITERATION SEE HOW IT WORKS: the new Desensibilize Nano P contains the new Nano P technology, based on nanoparticles of hydroxyapatite. Its desensitizing performance happens through two mechanisms: PHYSICAL EFFECT: for being nanometric, the hydroxyapatite penetrates more easily in the dentin tubules and in the enamel microcracks, which difficult the access of external stimuli that cause pain. CHEMICAL EFFECT: the presence of potassium nitrate potentializes the desensitization by the depolarization of nerve fibers; the presence of fluoride complements such desensitization effect. Opened dentin tubules BEFORE the treatment with the Desensibilize Nano P, enabling the sensitivity by the exposure to acids, to heat/cold, to air, to touch. The obliteration of the dentin tubules remains INTACT even AFTER THE EXPOSURE TO ACIDS. Dentin tubules CLOSED after the treatment with Desensibilize Nano P, blocking the diffusion of the pain-causing stimuli. The obliteration of the dentin tubules remains INTACT even AFTER THE BRUSHING WEAR. 1 2 21 3 4 Nano-hydroxyapatite + saliva: desensitization with resistance to the acid dissolution and to the brushing wear.
  6. 6. Desensitizing action of the Desensibilize Nano P throughout the treatment for the teeth that present initial severe or average (moderate) hypersensitivity. Courtesy of Dra. Constanza Odebrecht and partners of the Vale do Itajaí University – SC, Brazil. Relief of 80% of the sensitivity after the first application and of 90% after the second application. Medium 4,16% Severe 12,5% %oftheteethineachlevelofsensitivity Beginning Beginning Immediately after the 1st application Immediately after the 1st application Immediately after the 2nd application Immediately after the 2nd application Severe 100% 24 teeth Severe 25% 0 100 Medium 54,16% Light 8,33% Light 62,5% Null 12,5% Null 20,83% %oftheteethineachlevelofsensitivity Medium 100% 19 teeth Medium 21,05% Medium 10,52% 0 100 Light 68,42% Light 57,89% Null 10,52% Null 31,57% EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN Clinical studies show that Desensibilize Nano P promotes: RELIEF of the sensitivity IMMEDIATELY after the sole application of the product, and such effect is POTENTIALIZED THROUGHOUT THE FIRST 48 HOURS BY THE ACTION OF THE SALIVA ON THE NANOPARTICLES OF HYDROXYAPATITE; EFFECTIVE and LONG-LASTING TREATMENT of the sensitivity. EFFECTIVE AND LONG-LASTING TREATMENTEFFECTIVE AND LONG-LASTING TREATMENTEFFECTIVE AND LONG-LASTING TREATMENTEFFECTIVE AND LONG-LASTING TREATMENTEFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN 1 2
  7. 7. EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZING ACTION EFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZINGEFFECTIVE REMINERALIZING Remineralizing potential of Desensibilize Nano P on the surface of bovine enamel affected by artificial caries lesion, submitted to the pH cycling (des- and remineralization) for seven days. Different letters show statistic differences (p<0.05). c Recoveryofenamel’shardness(%) c c b,c b a Control CPP-ACP Fluoride in Gel Fluoride Varnish FluorCare (FGM) Desensibilize Nano P (FGM) 0 20 40 60 80 100 The remineralizing action of the Desensibilize Nano P occurs through two mechanisms: PHYSICAL EFFECT: the nanoparticles of hydroxyapatite penetrate in the porosities and enamel microcracks, easily integrating itself to the tooth, wich is also comprised by hydroxyapatite. They repair their deficiencies, functionally imitating it, acting as a system for the release of calcium and phosphate ions, essential for the maintenance of the mineral balance of the tooth in the demineralization conditions. CHEMICAL EFFECT: the presence of 9,000 ppm of fluoride inhibits the cariogenic activity of the bacteria and prevents the demineralization. SEE HOW IT WORKS: Lab studies show that Desensibilize Nano P promotes: RECOVERY of 70% of the HARDNESS of the enamel affected by caries. THE MAXIMUM EFFECT can already be noticed between the 2nd and the 3rd applications of the product. THE remineralizing EFFECT is POTENTIALIZED throughout the days by THE ACTION OF THE SALIVA on the nanoparticles of hydroxyapatite. EFFECTIVE AND LONG-LASTING REMINERALIZATION. Recovery of 70% of the hardness 1 1 2 3 2 4 c c c b,c b a
  8. 8. Wear of the bovine (µm) enamel structure (a) and dentin (b) after the erosive and abrasive demineralization, during five days. Different letters indicate statistical difference (p<0.05). Data given by Souza-e-Silva CM, Moron BM CAB, Magalhães AC, Buzalaf MAR, from Bauru Odontology University – USP, Brazil. Wearoftheenamel’sstructure(μm) b a a Enamel Desensibilize Nano P (FGM) Desensibilize Nano P (FGM) Mi Paste Plus (GC America) Control 0 1 2 3 4 5 6 Wearofthedentin’sstructure(μm) b b a Dentin Mi Paste Plus (GC America) Control 0 1 2 3 4 5 6 7 8 9 PHYSICAL EFFECT: the nanoparticles of hydroxyapatite penetrate in the enamel porosity and microcracks, and also in the dentin, easily integrating itself to the tooth and acting as a system for the release of calcium and phosphate ions in the conditions of erosive demineralization and abrasion. CHEMICAL EFFECT: the presence of 9,000 ppm prevents the demineralization. PREVENTION OF THE TOOTH WEAR BY EROSION AND ABRASION. SEE HOW IT WORKS: Its action in the prevention of the tooth erosion and of the abrasion occurs through two mechanisms: LAB STUDIES SHOW THAT DESENSIBILIZE NANO P IS EFFECTIVE IN THE 1 2 PREVENTION OF THE TOOTH WEAR BY EROSION AND ABRASION
  9. 9. STEP BY STEP For more information, check the technical profile available to download on our website. In case of doubts, check out technical support: contato@fgm.ind.br or by the telephone number +55 47 3441 6100. Dispense the product in a sterile Dappen pot and apply it on the tooth surface, with a micro-applicator (Cavibrush – FGM), or apply it directly on the tooth surface, with an application tip. Clean the surface of the tooth and perform the relative isolation. If necessary, conduct previous prophylaxis. 1 Remove the excess of the product with dry or slightly humid cotton pellet. Instruct the patient not to eat or drink for 30 minutes. 5 Leave the product resting for 5 minutes. With a felt disk adapted in low rotation with low speed (Diamond Flex – FGM), friction the product during 10 seconds. 3 4 2
  10. 10. Why the application of the Desensibilize Nano P brings more benefits to the remineralization process when compared to the application of other conventional Fluoride- based products? When a Fluoride-based conventional product is applied on the tooth surface, there is the formation of calcium fluoride CaF2 on the surface. Such CaF2 is initially stabilized by proteins and saliva phosphates in neutral pH. However, when the pH falls during acid challenges, the CaF2 is dissolved, releasing Ca2 and F, which will effectively contribute for the reorganization of the hydroxyapatite crystals of the tooth in fluorapatite, which can, then, actuate in a stable manner in the protection of the tooth against cavities. When we apply the Desensibilize Nano P on the surface of the tooth, we are offering nano- hydroxyapatite for it and, as we know, the hydroxyapatite is the organized crystal form of calcium phosphate, which composes the natural tooth, stable to the dissolution. This way, when we apply the Desensibilize Nano P, we already offer to the tooth a little bit of itself, facilitating the interaction between the tooth and the product, increasing the probability of formation of fluorapatite, amplifying the remineralizing potential of the product. In addition, as the nano- hydroxyapatite contained in the Desensibilize Nano P is highly resistant to dissolution, when it deposits itself on the tooth, it shall protect the hydroxyapatite of the tooth against dissolution. In average, how many sessions with the product are necessary to promote the remineralization of the teeth? Lab studies indicate that, after two applications of the Desensibilize Nano P its maximum remineralizing effect can already be observed. Based on these studies, for a better safety of the clinical protocol of application of the product, we recommend 3 to 4 applications of the Desensibilize Nano P when the purpose is the remineralization of the tooth surface. QUESTIONS AND ANSWERS 1 In average, how many sessions with the product are necessary to promote the desensitization of the teeth? The number of sessions may vary, but clinical studies performed (check technical profile) show that an average of 3 sessions is enough for the efficient and long-lasting treatment of the tooth sensitivity. 3 2
  11. 11. The Desensibilize Nano P is effective in the prevention of the tooth hypersensitivity related to the teeth whitening? So far, there aren’t conclusive data that indicate that the application of the Desensibilize Nano P is effective in the prevention of the hypersensitivity related to the teeth whitening. However, the application of the product after the whitening may contribute for the remineralization of the enamel surface, and also amplify the sensation of the whitening, in promoting the flattening of the tooth surface. The application of the Desensibilize Nano P before the teeth whitening may harm the whitening process? As the Desensibilize Nano P is comprised by nano- hydroxyapatite, which is the main constituent of the tooth enamel, the application of the product does not interfere in the whitening process. On the contrary, we may have a complementation of the whitening sensation, by the fact that the product may promote the flattening of the tooth surface. As it is a product with nanoparticles, could it present any risk for the patient in case of ingestion? Lab studies with cell culture show that the nanoparticles of hydroxyapatite contained in the Desensibilize Nano P are not toxic for the cells, which brings safety in a situation of ingestion of the product. Another factor that brings safety to the application of the Desensibilize Nano P is the fact it releases calcium and phosphate ions when it is solubilized, and such ions are already regulated (they are part of) by the metabolism of the individual. The most important care related to high dosages of the Desensibilize Nano P shall be in relation to the presence of the fluoride, which, if ingested in high quantities, may be toxic. Desensibilize Nano P contains 9,000 ppmF and, for this reason, it is only indicated for professional use. 4 5 6
  12. 12. DENTIN HYPERSENSITIVITY? EFFECTIVE AND LONG-LASTING TREATMENT. Your patient will thank you. Desensitizing and Remineralizing Agent HOW THE PAIN HAPPENS? Heat, cold and citric food, sweets, air and pressure are stimuli that may cause the movement of fluids in the dentin tubules, increasing the pressure inside of them, which stimulates the nerves inside the tooth, resulting in the pain. +55 47 3441 6100 | www.fgm.ind.br | twitter.com/fgmwhiteness | youtube.com/fgmprodutosodonto | contato@fgm.ind.br Product developed with support of: You’re worth it.

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