0
Jewish General Hospital  LIFE SCIENCES LIBRARY       Library              Workshop 4: Resident                 Presentatio...
Workshop 4 - ObjectivesBy the end of the workshop, you will be able to:1. Present clinical EBM summaries to your peers2. C...
Workshops July 25 - Introduction to EBM for Haematology Aug 8 -   Hands-on Searching Workshops Aug 22 - Critical Apprai...
EBM Process                                                    FormulatingWorkshop    Evaluating                          ...
Worksheets & Resources Critical Appraisal Worksheets from JAMA Evidence:  http://jamaevidence.com/ Critical Appraisal Wo...
Therapy (RCTs)1 1.    Are the results valid? A.    Did intervention and control groups start with the same prognosis?     ...
Therapy (RCTs), cont.2.   What are the results?A.   How large was the treatment effect?        What was the relative risk...
Therapy (RCTs), cont.3.   How can I apply the results to patient care?A.   Were the study patients similar to my populatio...
Harm (Cohort Studies, Case-Control Studies)2 1.    Are the results valid? Cohort Studies: Aside from the exposure of inter...
Harm (Cohort Studies, Case-Control Studies), cont.2.   What are the results?A.   How strong is the association between exp...
Harm (Cohort Studies, Case-Control Studies), cont.3.   How can I apply the results to patient care?A.   Were the study sub...
Summarizing the Evidence (Systematic Reviews)3 1.    Are the results valid? A. Did the review explicitly address a sensibl...
Summarizing the Evidence (Systematic                      Reviews), cont.2.   What are the results?A. Were the results sim...
Summarizing the Evidence (Systematic Reviews),                         cont.3.    How can I apply the results to patient c...
Next Workshop 10:30 am to 12:30 pm Rm 519 (Dean’s conference room), McIntyre Medical Building, McGill Slides available:...
Upcoming SlideShare
Loading in...5
×

Resident Presentations - Evidence-Based Medicine for Haematology

797

Published on

Workshop facilitated for haematology residents on September 5, 2012 at the Jewish General Hospital, Montreal.

Published in: Health & Medicine, Education
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
797
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
23
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide
  • Process can also be described as: Ask, Acquire, Appraise, Apply and Assess
  • Transcript of "Resident Presentations - Evidence-Based Medicine for Haematology"

    1. 1. Jewish General Hospital LIFE SCIENCES LIBRARY Library Workshop 4: Resident Presentations Chantal Cassis, MD Robin Featherstone, MLIS Francesca Frati, MLISSummer/Fall 2012 Roland Grad, MDCM, MSc, FCFP
    2. 2. Workshop 4 - ObjectivesBy the end of the workshop, you will be able to:1. Present clinical EBM summaries to your peers2. Critically reflect on the practical application of a clinical study
    3. 3. Workshops July 25 - Introduction to EBM for Haematology Aug 8 - Hands-on Searching Workshops Aug 22 - Critical Appraisal Sept 5 - Resident Presentations Sept 19 - Review
    4. 4. EBM Process FormulatingWorkshop Evaluating the clinical the Process Workshop 5 question 1 Your patient for whom you are uncertain about therapy, diagnosis, or Searching Incorporating prognosis the Evidence evidence into Workshop decision-making 2 WorkshopWorkshop 3 4 Appraising the Evidence
    5. 5. Worksheets & Resources Critical Appraisal Worksheets from JAMA Evidence: http://jamaevidence.com/ Critical Appraisal Worksheets from Dartmouth (include calculations for odds ratio, relative risk, absolute risk, etc.): http://www.dartmouth.edu/~library/biomed/guides /research/ebm-teach.html
    6. 6. Therapy (RCTs)1 1. Are the results valid? A. Did intervention and control groups start with the same prognosis?  Were patients randomized?  Was group allocation concealed?  Were patients in the study groups similar with respect to known prognostic variables? B. Was prognostic balance maintained as the study progressed?  To what extent was the study blinded? C. Were the groups prognostically balanced as the study progressed?  Was follow-up complete?  Were patients analyzed in the groups to which they were first allocated?  Was the trial stopped early?1. http://jamaevidence.com/criticalAppraisalWorksheet/27
    7. 7. Therapy (RCTs), cont.2. What are the results?A. How large was the treatment effect?  What was the relative risk reduction?  What was the absolute risk reduction?B. How precise was the estimate of the treatment effect?  What were the confidence intervals?
    8. 8. Therapy (RCTs), cont.3. How can I apply the results to patient care?A. Were the study patients similar to my population of interest?  Does your population match the study inclusion criteria ?  If not, are there compelling reasons why the results should not apply to your population?B. Were all clinically important outcomes considered?  What were the primary and secondary endpoints studied?  Were surrogate endpoints used?C. Are the likely treatment benefits worth the potential harm and costs?  What is the number needed to treat (NNT) to prevent 1 adverse outcome or produce 1 positive outcome?  Is the retention of clinical endpoints worth the increase of cost and risk of harm? 
    9. 9. Harm (Cohort Studies, Case-Control Studies)2 1. Are the results valid? Cohort Studies: Aside from the exposure of interest, did the exposed and control groups start and finish with the same risk for the outcome?  Were patients similar for prognostic factors known to be associated with the outcome (or was statistical adjustment done)?  Were the circumstances and methods for detecting the outcome similar?  Was the follow-up sufficiently complete? Case-Control Studies: Did the cases and control group have the same rise (chance) for being exposed in the past?  Were cases and controls similar with respect to the indication or circumstances that would lead to exposure?  Were the circumstances and methods for determining exposure similar for cases and controls?2. http://jamaevidence.com/criticalAppraisalWorksheet/23
    10. 10. Harm (Cohort Studies, Case-Control Studies), cont.2. What are the results?A. How strong is the association between exposure and outcome?  What is the risk or odds ratio?  Is there a dose-response relationship between exposure and outcome?B. How precise was the estimate of the risk?  What is the confidence interval for the relative risk or odds ratio?
    11. 11. Harm (Cohort Studies, Case-Control Studies), cont.3. How can I apply the results to patient care?A. Were the study subjects similar to your patients or population?  Is your patient so different from those included in the study that the results may not apply?B. Was the follow-up sufficiently long?  Were study participants followed-up long enough for important harmful effects to be detected?C. Is the exposure similar to what might occur in your patient?  Are there important differences in exposures (dose, duration, etc.) for your patients?D. What is the magnitude of the risk?  What level of baseline risk for the harm is amplified by the exposure studied?E. Are there any benefits known to be associated with the exposure?  What is the balance between benefits and harms for patients like yours?
    12. 12. Summarizing the Evidence (Systematic Reviews)3 1. Are the results valid? A. Did the review explicitly address a sensible clinical question?  Is the underlying biology or sociology such that, across the range of interventions and outcomes included, the effect should be similar?  Did the review include explicit and appropriate eligibility criteria? B. Was the search for relevant studies detailed and exhaustive?  Were sources of evidence and search strategies specified in sufficient detail for replication  Was the likelihood and direction of publication bias considered? C. Were the primary studies of high methodologic quality?  Were clear methodological selection criteria specified?  Were all included studies accessed by these criteria? D. Were selection and assessments of studies reproducible?  Was an explicit approach used to select and extract data from all included studies?  Was study selection and assessment validated by a blinded second observer?3. http://jamaevidence.com/criticalAppraisalWorksheet/26
    13. 13. Summarizing the Evidence (Systematic Reviews), cont.2. What are the results?A. Were the results similar from study to study?  How similar were the point estimates?  Do confidence intervals overlap between studies?B. What are the overall results of the review?  Were results weighted both quantitatively and qualitatively in summary estimates?C. How precise were the results?  What is the confidence interval for the summary or cumulative effect size?
    14. 14. Summarizing the Evidence (Systematic Reviews), cont.3. How can I apply the results to patient care?A. Were all patient-important outcomes considered?  Did the review omit outcomes that could change decisions?B. Are any postulated subgroup effects credible?  Were subgroup differences postulated before data analysis?  Were subgroup differences consistent across studies?C. What is the overall quality of the evidence?  Were prevailing study design, size, and conduct reflected in a summary of the quality of evidence?D. Are the benefits worth the costs and potential risks  Does the cumulative effect size cross a test or therapeutic threshold?
    15. 15. Next Workshop 10:30 am to 12:30 pm Rm 519 (Dean’s conference room), McIntyre Medical Building, McGill Slides available: http://www.slideshare.net/featherr
    1. A particular slide catching your eye?

      Clipping is a handy way to collect important slides you want to go back to later.

    ×