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11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
11.12 (dr. husun bano) membrane potential part i
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11.12 (dr. husun bano) membrane potential part i

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  • 1. MEMBRANE POTENTIAL(Part-1) Husan Bano Assistant Professor Deptt. Physiology SMC,DUHS
  • 2. BY THE END OF THIS LECTURE YOU SHOULD BE ABLE TO :
    • COMPARE THE CHRACTERSTIC OF EXCITABLE AND NON EXCITABLE CELLS
    • DEFINE THE RESTING MEMBRENE POTENTIAL
    • EXPLAIN THE GENERATION AND MAINTAINANCE OF RESTING MEMBRANE POTENTIAL.
  • 3. TYPES OF CELLS
    • EXCITABLE CELLS
    • NON-EXCITABLE CELLS
  • 4. EXCITABLE CELLS
    • EXSIST HIGH ELECTRICAL POTENTIAL DIFFERENCE ACROSS THE MEMBRANE
    • GENERATE ACTION POTENTIAL
    • PROPAGATE ACTION POTENTIAL
    • e.g. Nerve & Muscle
  • 5. EXCITABLE CELL
  • 6. NON-EXCITABLE CELLS
    • LOW POTENTIAL DIFFERENCE ACROSS THE MEMBERANE.
    • DO NOT GENERATE AND PROPAGATE ACTION POTENTIAL.
    • e.g. Glandular cells, Macrophages, Blood cells etc
  • 7. RESTING STATE
  • 8. GENERATION OF RESTING MEMBERANE POTENTIAL
    • IONIC DESTRIBUTION OF ICF AND ECF
    3-5 103-105 Cl - (mEq/L) 200 ABSENT PROTEIN(-) 140 3-5 K + (mEq/L) 10 140 Na + (mEq/L) Intracellular Fluid* Extracellular Fluid Substance and Units
  • 9. ION FLUXES IN RESTING STATE
    • Na + 142meq/L PO4-- 4meq/L
    • K + 5 -10 P- absent
    • Cl - 103-105 ECF
    • -------------------------------------------------------------
    • Na + 10meq/L PO 4 - - 75 m.eq/L ICF
    • K + 142 P - 200 mg%
    • Cl – 3-5
    • ------------------------------------------------------------
  • 10. SODIUM-POTASSIUM PUMP
  • 11. SODIUM-POTASSIUM PUMP
  • 12. ION FLUXES
  • 13. REASONS OF RMP
    • ACTIVE TRANSPORT OF SODIUM IONS FROM ICF TO ECF.
    • PASSIVE TRANSPORT OF POTASSIUM IONS FROM ICF TO ECF.
    • PASSIVE TRANSPORT OF CHLORIDE IONS FROM ECF TOICF.
  • 14. ~~~ Cont.
    • 4. PRESENCE OF NEGATIVELY CHARGED PROTEIN IONS AND PHOSPHATE IONS IN ICF
  • 15. RMP OF DIFFERENT EXCITABLE CELL
    • Due to the combine reason. the RMP of an excitable cell ranges from -60mv to -90 mv
    • eg.
    • -60 mv ( Smooth muscle)
    • -90 mv ( Skeletal muscle)
    • -90 mv ( Nerve fiber )
    • -85mv to -90mv (Cardiac muscle)
  • 16. DEFINATION OF RMP
    • The potential difference accrose the membrane in resting condition is called resting membrane potential (RMP).
  • 17.
    • THE END
    THANKS

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