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11.11(dr. husun bano) mitochondria lysosomes &peroxisomes
 

11.11(dr. husun bano) mitochondria lysosomes &peroxisomes

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    11.11(dr. husun bano) mitochondria lysosomes &peroxisomes 11.11(dr. husun bano) mitochondria lysosomes &peroxisomes Presentation Transcript

    • MITOCHONDRIA AND LYSOSOMES HUSAN BANO Assistant Professor Deptt. Physiology. SMC
    • Mitochondrial Structure (cont.)
    • MITOCHONDRIAL MEMBRANE
      • Outer layer
      • Inner layer
      • Contents of outer layer:
      • Smooth layer containing various enzymes.
      • Acetyl COA
      • Glycerol-phosphate-acetyltransferase
    • Contents of inner layer
      • Have in-foldings called “cristae”.
      • Cristae contains “oxidative enzymes” and “protein molecules” involved in respiration and ATP synthesis, so called “Respiratory chain” or “electron transport system”
    • RESPIRATORY CHAIN INCLUDES:
      • Succinic dehydrogenase
      • Dihydro-nicotinamide-adenin dinucleotide
      • (NADH).
      • Cytochrome oxidase
      • Cytochrome-C
      • ATP synthetase
    • MITCHONDRIAL MATRIX
      • Dissolved enzymes
      • DNA
      • RNA
    • FUNCTIONS OF MITOCHONDRIA
      • Energy Production
      • Nutrients CO2 + H2O + Energy
      • Synthesis of ATP
      • Used in:
      • a. Protein synthesis
      • b. Muscle contraction
      • c. Ionic transport
    • Cont….
      • APOPTOSIS : Means “Programmed cell death ”
      • Under genetic control.
      • Normal phenomena
      • Presences of cytochrome-C
    • If a cell did not have mitochondria, it would be unable to:
      • 1. move
      • 2. produce energy
      • 3. synthetize protein
      • 4. synthesize enzyemes
    • LYSOSOMES
      • STRUCTURE OF LYSOMES
      • They are rounded dense bodies.
      • They are membrane bounded organalle
      • Contains variety of “hydrolytic enzymes”
      • Digest the foreign bodies.
      • Most abundenly found in lungs,spleen and WBC
    • LYSOMES AND PEROXISOMES
    • LYSOSOMES
      • Structure of lysomes:
    • FORMATION OF LYSOSOMES AND LYSOSOMAL ENZYMES
      • Lysosomal enzymes produced on ribosome.
      • They are channel into matrix of endoplasmic reticulum.
      • Goes to golgi appratus
      • Package in the form of secretory granules or “primary lysosomes”
    • FORMATION OF LYSOSOMES
    • FUNCTIONS OF LYSOSOMES
      • It act as digestive system of single typical cell.
      • Play an important role in removal of damage portion of cell, if the cell damage by heat, cold, trauma or chemical
    • FUNCTIONS OF LYSOSOMES Cont …..
      • It has bactericidal action .
    • PEROXISOMES
      • It is membrane bounded organalle.
      • Also called micro bodies.
      • It is formed by pinched off from ER.
      • Contain “Oxidative enzymes” such as CATALASE, URATE OXIDASE and
      • D-AMINO ACID OXIDASE
    •  
    •  
    • FUNCTIONS OF PEROXISOME
      • Detoxification
      • Form the site of oxygen utilization in the cell.
      • Breakdown the excess fatty acids.
      • Accelerate gluconeogensis from fats.
      • Degrade purine to uric acid.
      • Participate in the formation of myelin and bile salts.
    • THANKS