Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin Marked improvement in lipid profile compared to plain Atorvastatin. Reduction in Oxidized LDL, an effect not achieved by up-titration of statin dose. Reduces cholesterol absorption specially in diabetic patients with CAD. Ezastatin with 40 mg atorvastatin concentration to benefit from pleiotropic effects of atorvastatin. Ezastatin reduces CIMT compared to standard and aggressive therapy. Higher safety profile than maximizing atorvastatin dose to 80mg

2. Coronary Artery Disease Risk

3. Coronary Artery Disease Risk

4. Are LDL-C Goals The Same For
All Patients With Dyslipideamia?

5. Coronary Artery Disease Risk
ATP III modification

6. Debate
 Can we achieve these goals with Statin
mono therapy alone ?
 At which Statin concentration ?
 Is it enough to achieve normal lipid profile
only ? what else ?
 What about increase exogenous
cholesterol absorption in diabetics?

7. Coronary Artery Disease Risk
Statins monotherapy limitations

8. Coronary Artery Disease Risk
Statins monotherapy limitations

9. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

10. MANAGEMENT OF DIABETIC
DYSLIPIDEMIA: RECENT
ADVANCES IN COMBINATION
THERAPY

11. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

12. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

13. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

14. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

15. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

16. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

17. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

18. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

19. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

20. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

22. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

23. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

24. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

25. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

26. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

27. Fill the unmet need in
lipid lowering managementEzastatin
atorvastatin + ezetimibe

28. Why Ezastatin
 Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin
 Marked improvement in lipid profile compared to plain
Atorvastatin.
 Reduction in Oxidized LDL, an effect not achieved by up-titration
of statin dose.
 Reduces cholesterol absorption specially in diabetic patients
with CAD.
 Ezastatin with 40 mg atorvastatin concentration to benefit from
pleiotropic effects of atorvastatin.
 Ezastatin reduces CIMT compared to standard and aggressive
therapy.
 Higher safety profile than maximizing atorvastatin dose to 80mg.

29. Ezastatin
atorvastatin + ezetimibe
Fill the unmet need in
lipid lowering management

32. THANK YOU