Ezastatin ( The Art of Combination Therapy)

  • 333 views
Uploaded on

Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin …

Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin
Marked improvement in lipid profile compared to plain Atorvastatin.
Reduction in Oxidized LDL, an effect not achieved by up-titration of statin dose.
Reduces cholesterol absorption specially in diabetic patients with CAD.
Ezastatin with 40 mg atorvastatin concentration to benefit from pleiotropic effects of atorvastatin.
Ezastatin reduces CIMT compared to standard and aggressive therapy.
Higher safety profile than maximizing atorvastatin dose to 80mg

  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
No Downloads

Views

Total Views
333
On Slideshare
0
From Embeds
0
Number of Embeds
0

Actions

Shares
Downloads
12
Comments
0
Likes
1

Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
    No notes for slide
  • Very High Risk Patients:1-Documented CVD whether by invasive such as coronary angiography or non invasive such as stress echocardiography, previous MI , PCI , CABAG ,and other arterial revascularization procedures , stroke , PAD2-Patients with Type-2 Diabetes or Type-1 with target organ damage ( Microalbuminuria )3-Patient with moderate to sever CKD with GFR < 604-A calculated 10 risk score >= 10

Transcript

  • 1. Coronary Artery Disease Risk
  • 2. Coronary Artery Disease Risk
  • 3. Are LDL-C Goals The Same ForAll Patients With Dyslipideamia?
  • 4. Coronary Artery Disease RiskATP III modification
  • 5. Debate Can we achieve these goals with Statinmono therapy alone ? At which Statin concentration ? Is it enough to achieve normal lipid profileonly ? what else ? What about increase exogenouscholesterol absorption in diabetics?
  • 6. Coronary Artery Disease RiskStatins monotherapy limitations
  • 7. Coronary Artery Disease RiskStatins monotherapy limitations
  • 8. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 9. MANAGEMENT OF DIABETICDYSLIPIDEMIA: RECENTADVANCES IN COMBINATIONTHERAPY
  • 10. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 11. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 12. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 13. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 14. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 15. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 16. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 17. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 18. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 19. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 20. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 21. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 22. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 23. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 24. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 25. Fill the unmet need inlipid lowering managementEzastatinatorvastatin + ezetimibe
  • 26. Why Ezastatin Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin Marked improvement in lipid profile compared to plainAtorvastatin. Reduction in Oxidized LDL, an effect not achieved by up-titrationof statin dose. Reduces cholesterol absorption specially in diabetic patientswith CAD. Ezastatin with 40 mg atorvastatin concentration to benefit frompleiotropic effects of atorvastatin. Ezastatin reduces CIMT compared to standard and aggressivetherapy. Higher safety profile than maximizing atorvastatin dose to 80mg.
  • 27. Ezastatinatorvastatin + ezetimibeFill the unmet need inlipid lowering management
  • 28. THANK YOU