Dorsal column pathway


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  • Slide3...Layers of the skin are incorrect. The blue layer that is labeled 'dermis' is actually a part of the EPIDERMIS. The blue layer consists of the stratum basale (stratum germinativum), stratum spinosum, stratum granulosum, stratum lucidum--palms and soles, and stratum corneum...these layers are listed from the bottom to the top. The DERMIS contains blood vessels, nerve endings, sweat glands, oil glands, etc. I hope this clears things up a bit. Thank you.
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Dorsal column pathway

  1. 1. Dorsal column pathway DR SYED TOUSIF AHMED
  2. 2. General Sensory Receptors Sensory pathways Spinocerebellar Pathway Posterior Column Pathways Anteriolatheral Pathways Posterior Tract Anterior Tract Fasciculus Cuneatus Fasciculus Gracilis Latheral Tract Anterior Tract Sensory Pathways
  3. 3. Cutaneous sensory receptors Smooth skin (glaborous ) Hairy skin Free nerve endings The receptor location and its associated structure can alter the stimulus and influence the response Subcutis Dermis Epidermis Merkel disks detect steady pressure & are slowly adapting Free nerve endings around hair root can be either rapid or slowly adapting - depends on hair type Meissner’s corpuscles detect flutter & are rapidly adapting Pacinian corpuscles detect vibration & are very rapidly adapting Ruffini corpuscles detect steady pressure at higher threshold & are slowly adapting Free nerve endings in the skin are modality specific and can detect either pain or touch or pressure or temperature
  4. 4. Tactile Sensations <ul><li>arise by activation encapsulated mechanoreceptors </li></ul><ul><ul><li>touch </li></ul></ul><ul><ul><li>pressure </li></ul></ul><ul><ul><li>vibration </li></ul></ul><ul><li>arise by activation of free nerve endings </li></ul><ul><ul><li>itch </li></ul></ul><ul><ul><li>tickle </li></ul></ul>
  5. 5. Touch <ul><li>Crude touch </li></ul><ul><ul><li>ability to perceive that something contacted skin </li></ul></ul><ul><ul><li>exact location, shape, size, or texture cannot be detected </li></ul></ul><ul><li>Fine touch </li></ul><ul><ul><li>provides specific information about location, shape, size, and texture of stimuli </li></ul></ul>
  6. 6. Proprioreceptors <ul><li>Intrinsic knowledge of limb position is known as kinaesthesia. </li></ul><ul><li>Information is provided by sensory input from muscle spindles (Ia & II) and Golgi tendon organs. </li></ul><ul><li>These are mechanoreceptors and provide the CNS with information on muscle length, position and tension. </li></ul><ul><li>Muscle spindle group Ia afferent fibres are rapidly adapting (dynamic) and are sensitive to rapid changes in muscle length. </li></ul><ul><li>Muscle spindle group II afferent fibres are slowly adapting (static) and single the fixed length of the muscle. </li></ul>
  7. 7. Joint Kinesthetic Receptors <ul><li>located within and around articular capsules of synovial joints </li></ul><ul><li>perception of body movements </li></ul><ul><li>several types </li></ul><ul><ul><li>free nerve endings and type II cutaneous mechanoreceptors </li></ul></ul><ul><ul><ul><li>in capsules of joint and respond to pressure </li></ul></ul></ul><ul><ul><li>small lamellated corpuscles </li></ul></ul><ul><ul><ul><li>respond to acceleration and deceleration of joints during movement </li></ul></ul></ul><ul><ul><li>articular ligaments contain receptors similar to tendon organs </li></ul></ul><ul><ul><ul><li>adjust the contraction of adjacent muscles when excessive strain is placed on joint </li></ul></ul></ul>
  8. 8. Two-Point Discrimination
  9. 9. Processing at Receptor Level <ul><li>Receptor must have specificity for stimulus activity </li></ul><ul><li>Stimulus must be applied to receptive field </li></ul><ul><li>Transduction must occur </li></ul><ul><li>Generator potential in 1 st order neuron must reach threshold </li></ul><ul><li>How is information about stimulus encoded? </li></ul><ul><li>Tonic receptors (slow adapting) </li></ul><ul><li>Phasic receptors (fast adapting) </li></ul><ul><li>Adaptation </li></ul>
  10. 10. <ul><li>Rapidly adapting cutaneous mechanoreceptors signal the onset and offset (phasic) of a stimulus and give rise to sensations such as vibration, touch, and movement </li></ul><ul><li>Slowly adapting mechanoreceptors continuously signal (tonic) the intensity of the stimulus and give rise to the sensation of pressure. </li></ul><ul><li>Cutaneous receptors with small receptive fields are involved in fine spatial discrimination, whereas receptors with larger receptive fields are less spatially precise. </li></ul><ul><li>Overlap of receptive fields allows lateral inhibition to occur in the ascending pathways and increase sensory acuity. </li></ul>Cutaneous mechanoreceptors
  11. 11. Somatosensory system receptor classification
  12. 12. First-Order Neuron <ul><li>Sensory neuron delivers information to CNS </li></ul><ul><li>Cell body is located in dorsal root ganglion </li></ul><ul><li>Synapses with interneurons in CNS </li></ul>
  13. 13. Second-Order Neuron <ul><li>Usually interneurons receiving information from first order neurons </li></ul><ul><li>Axons cross to opposite sides of body </li></ul><ul><ul><li>Decussation </li></ul></ul><ul><li>May be located in the spinal cord or brain stem </li></ul>
  14. 14. Third-Order Neuron <ul><li>Located in thalamus </li></ul><ul><li>Carries information to cerebrum </li></ul><ul><li>Synapses with neurons of the primary sensory cortex </li></ul>
  15. 15. Ascending Pathways to Brain <ul><li>What type of information do the neurons carry? </li></ul><ul><li>3 chains of successive neurons to brain </li></ul><ul><ul><li>1 st order neurons </li></ul></ul><ul><ul><ul><li>Where is cell body? </li></ul></ul></ul><ul><ul><ul><li>Conduct impulses from cutaneous receptors and proprioceptors </li></ul></ul></ul><ul><ul><ul><li>Synapse w/ 2 nd order </li></ul></ul></ul><ul><ul><li>2 nd order neurons </li></ul></ul><ul><ul><ul><li>Cell bodies in dorsal horn or in medullary nuclei </li></ul></ul></ul><ul><ul><ul><li>Transmit impulses to thalamus or cerebellum; synapse </li></ul></ul></ul><ul><ul><li>3 rd order neurons </li></ul></ul><ul><ul><ul><li>In thalamus </li></ul></ul></ul><ul><ul><ul><li>Where do they conduct information to? </li></ul></ul></ul><ul><ul><ul><li>No 3 rd order neurons in cerebellum </li></ul></ul></ul>
  16. 16. <ul><li>First order neurons </li></ul><ul><ul><li>Sensory neurons that deliver sensory information to the CNS </li></ul></ul><ul><li>Second order neurons </li></ul><ul><ul><li>First order neurons synapse on these in the brain or spinal cord </li></ul></ul><ul><li>Third order neurons </li></ul><ul><ul><li>Found in the thalamus </li></ul></ul><ul><ul><li>Second order neurons synapse on these </li></ul></ul><ul><li>Only 1% of incoming sensory impulses actually reach the cerebrum. </li></ul>First, second, and third order neurons The Organization of Sensory Pathways
  17. 17. Posterior Column Pathway <ul><li>Carries sensations of highly localized (fine) touch, pressure, vibration, proprioception </li></ul><ul><li>Spinal Tracts Involved: </li></ul><ul><ul><li>Left/right fasciculus gracilis </li></ul></ul><ul><ul><li>Left/right fasciculus cuneatus </li></ul></ul>
  18. 18. Peripheral nerves system
  19. 19. Sensory Pathways and Ascending Tracts in the Spinal Cord
  20. 20. dorsal cloumn pathway
  21. 21. Dorsal column pathway
  22. 22. Dorsal-column leminiscal pathway <ul><li>Principally conveys tactile discrimination, vibratory and position senses (A  ,large fibres). </li></ul><ul><li>1st order sensory neurones run on the same side & synapse with 2nd order neurones in the dorsal column nuclei . </li></ul><ul><li>2nd order neurones integrate the input and their axons cross to the opposite side. These ascend through the medial leminiscus </li></ul><ul><li>Further integration in the thalamus & 3rd order neurones project to the cortex. </li></ul>
  23. 23. The Posterior Column Pathway and the Spinothalamic Tracts The area of sensory cortex devoted to a body region is relative to the number of sensory receptors.
  24. 24. Dorsal column pathway Large sensory nerves: Touch, vibration, two-point discrimination, proprioception Primary somatosensory cortex (S1) in parietal lobe Thalamus Medulla Medial lemniscus Spinal cord Dorsal column Dorsal column nuclei
  25. 25. Dorsal column damage dorsal column pathway Left spinal cord injury <ul><li>Loss of sense of: </li></ul><ul><li>touch </li></ul><ul><li>proprioception </li></ul><ul><li>vibration </li></ul><ul><li>in left leg </li></ul>
  26. 26. Dorsal column damage <ul><li>Sensory ataxia </li></ul><ul><li>Patient staggers; cannot perceive position or movement of legs </li></ul><ul><li>Visual clues help movement </li></ul>
  27. 27. Central Pathways
  28. 28. 3.3 Spinocerebellar pathway <ul><li>Carries unconscious proprioception signals </li></ul><ul><li>Receptors in muscles & joints </li></ul><ul><li>1 st neuron: enters spinal cord through dorsal root </li></ul><ul><li>2 nd neuron: ascends to cerebellum </li></ul><ul><li>No 3 rd neuron to cortex, hence unconscious </li></ul>
  29. 29. <ul><li>Coding in the sensory system could theoretically follow: </li></ul><ul><ul><li>The labeled-line principle in which each receptor responds to a limited range of stimuli and sends a direct line to the brain. </li></ul></ul><ul><ul><li>2 . Across-fiber pattern in which each receptor responds to a wider range of stimuli and contributes to the perception of each of them. </li></ul></ul>
  30. 30. THANK YOU