Connective Tissues<br />
Connective Tissues<br />Responsible for providing and maintaining form in the body<br />
Histogenesis<br />Mesodermal in origin<br />
General Characteristics<br />Are made up of fewer cells that are set far apart<br />They are supported by abundant interce...
General Functions<br />Provide a matrix that serves to connect and bind the cells and organs<br />Give mechanical support ...
Classification<br />I.    Connective Tissue Proper<br />          Loose connective Tissue<br />          Dense connective ...
Composition of Connective Tissues<br />Connective tissue cells<br />Connective tissue fibers<br />Intercellular or Ground ...
Connective Tissue cells<br />Fixed or permanent<br />Wandering cells<br />Are immigrant cells usually from blood or bone m...
Fixed Connective Tissue Cells<br />
Undifferentiated Mesenchymal cells<br />Precursor of most cells indigenous to CT including fibroblasts and adipose cells<b...
Fibroblasts<br />Predominant CT cells<br />Considered to be responsible for the formation of the fibers and are also thoug...
Fibroblasts<br />
Macrophages<br />As numerous as fibroblasts in loose CT<br />Often termed histiocytes,  are most abundant in richly vascul...
Macrophages<br />Act as scavengers, (motility and phagocytic activity) engulfing extravasated blood cells, dead cells, bac...
Fat cells<br />Fully differentiated cells and are incapable of mitotic division<br />Signet-ring appearance – cytoplasm is...
Fat cells<br />
Wandering Connective Tissue Cells<br />
Mast cells<br />Round to oval CT cells whose cytoplasm is filled with basophilic granules<br />The rather small and spheri...
Mast cells<br />Also elaborate serotonin, a vasoconstrictor<br />Are only seen along the course of small blood vessels<br />
Plasma cells<br />Spherical cells with rounded or irregular nuclei generally eccentrically located , whose chromatin mater...
Plasma Cells<br />
Pigment cells<br />Resemble the fibroblast but whose cytoplasm contains pigment granules that never invade the nucleus<br ...
Blood Leukocytes<br />
Lymphocytes<br />Smallest, with rounded nucleus which occupies most of the cytoplasm<br />Concerned with antibody producti...
Eosinophils<br />Have bilobed nucleus with spherical, darkly staining acidophilic granules<br />Found abundant in lactatin...
Neutrophils<br />First line of defense, seen in regions of acute inflammation<br />Have a segmented nucleus (3-5 lobes) ha...
Monocytes<br />Largest, they have a kidney-shaped nucleus and are considered as the phagocytes of the blood<br />
Connective tissue cells<br />
Ground Substance<br />
Ground substance<br />Colorless, transparent and homogenous<br />Fills the space between cells and fibers of the CT<br />I...
Connective Tissue Fibers<br />Collagen          formed by the protein collagen,            <br />Reticular         most ab...
Collagen fibers<br />Most numerous fiber in CT<br />Fibers are colorless stands, but when present in great numbers, they c...
Collagen fibers<br />Consists of closely packed thick fibrils with an average diameter of 75 nm<br />In many parts of the ...
Types of Collages fibers<br />Collagen type I<br />Most abundant and has a widespread distribution (90% of the collagen in...
Types of collagen fibers<br />Collagen type III<br />Often found in association with type I and is probably the major coll...
Reticular fibers<br />Are extremely thin, with a diameter between 0.5 and 2 μm<br />Not visible in hematoxylin and eosin s...
Reticular fibers<br />Particularly abundant in smooth muscles, endoneurium, and the framework of hematopoietic organs (e.g...
Elastic fibers<br />Consists of an albuminoid protein called elastin<br />Range in diameter from 0.1 to 10 µm<br />Histolo...
Elastic fibers<br />Found where their mechanical properties are necessary to allow tissues to stretch or expand and then r...
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Connective tissues

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Connective tissues

  1. 1. Connective Tissues<br />
  2. 2. Connective Tissues<br />Responsible for providing and maintaining form in the body<br />
  3. 3. Histogenesis<br />Mesodermal in origin<br />
  4. 4. General Characteristics<br />Are made up of fewer cells that are set far apart<br />They are supported by abundant intercellular substance<br />They also contain connective tissue fibers<br />The different contents of intercellular substance, CT cells and fibers account for the difference in appearance of the various connective tissues<br />
  5. 5. General Functions<br />Provide a matrix that serves to connect and bind the cells and organs<br />Give mechanical support to the body<br />Storage of fat and certain minerals like calcium in the bones<br />Exchange of metabolites between blood and tissues<br />Significant role in the repair and healing of wounds<br />For protection against infection<br />
  6. 6. Classification<br />I. Connective Tissue Proper<br /> Loose connective Tissue<br /> Dense connective tissue – regular & irregular<br />II. Connective Tissue with special properties<br /> Adipose CT<br /> Elastic CT<br /> Hematopoietic CT(lymphatic and myeloid)<br /> Mucous CT<br />III. Suporting Connective Tissue<br /> Cartilage <br /> Bone <br />
  7. 7. Composition of Connective Tissues<br />Connective tissue cells<br />Connective tissue fibers<br />Intercellular or Ground substance<br />Blood vessels – except in Mucous CT and in cartilage<br />
  8. 8. Connective Tissue cells<br />Fixed or permanent<br />Wandering cells<br />Are immigrant cells usually from blood or bone marrow. Some retain their original characteristics and may take up permanent residence there:<br /> 1. mast cells<br /> 2. plasma cells<br /> 3. pigment cells<br /> 4. blood leukocytes<br />Are native to the tissue in which they are found:<br /> 1. undifferentiated mesenchymal cells<br /> 2. fibroblasts<br /> 3. macrophages<br /> 4. fat cells<br />
  9. 9. Fixed Connective Tissue Cells<br />
  10. 10. Undifferentiated Mesenchymal cells<br />Precursor of most cells indigenous to CT including fibroblasts and adipose cells<br />Adventitial cells remain undiifferentiated in adult CT and constitute a reserve population of stem cells<br />Perivascular cells, often located along the walls of blood vessels<br />Are difficult to distinguish from active fibroblasts – recognition come not with the microscope but from numerous observations of their responses to certain stimuli<br />Pluripotential cells, capable of differentiation either into the usual cell types or into other cell types such as smooth muscle cells<br />
  11. 11. Fibroblasts<br />Predominant CT cells<br />Considered to be responsible for the formation of the fibers and are also thought to elaborate most, if not all, of the amourpous ground substance<br />Are large, flat branching cells which appear fusiform or spindle shaped in profile<br />Classified as:<br /> lamellar or pyriform-shaped (youngest)<br />Spindle or fusiform (intermediate in age)<br />Stellate or star-shaped (mature)<br />
  12. 12. Fibroblasts<br />
  13. 13. Macrophages<br />As numerous as fibroblasts in loose CT<br />Often termed histiocytes, are most abundant in richly vascularized areas<br />May either be:<br />Fixed or resting (attached to the fibers of the matrix)<br />Free, wandering (derived from the immigration of monocytes from the blood)<br /> Capable of ameboid movement – very irregular in outline with pseudopodia extending in numerous directions<br />
  14. 14. Macrophages<br />Act as scavengers, (motility and phagocytic activity) engulfing extravasated blood cells, dead cells, bacteria and foreign bodies<br />
  15. 15. Fat cells<br />Fully differentiated cells and are incapable of mitotic division<br />Signet-ring appearance – cytoplasm is so thinned that it appears as a narrow rim around the edge of a single large lipid droplet with the nucleus fused to one side of the cell membrane<br />Types:<br />Yellow or white – found in most of the bulk of the human body<br />Brown fat cells – concerned with heat production, particularly important in newborn and young animals<br />
  16. 16. Fat cells<br />
  17. 17.
  18. 18. Wandering Connective Tissue Cells<br />
  19. 19. Mast cells<br />Round to oval CT cells whose cytoplasm is filled with basophilic granules<br />The rather small and spherical nucleus is centrally situated and is frequently obscured by the cytoplasmic granules<br />Produce an anticoagulant similar if not identical to heparin<br />Produce histamine in allergic response to some foreign proteins<br />
  20. 20. Mast cells<br />Also elaborate serotonin, a vasoconstrictor<br />Are only seen along the course of small blood vessels<br />
  21. 21. Plasma cells<br />Spherical cells with rounded or irregular nuclei generally eccentrically located , whose chromatin materials exhibit a characteristic “checker-board”, “clock-faced”, “cart-wheel” appearance <br />Has an important function in resistance to disease and known as the: principal producer of antibodies<br />
  22. 22. Plasma Cells<br />
  23. 23. Pigment cells<br />Resemble the fibroblast but whose cytoplasm contains pigment granules that never invade the nucleus<br />Types:<br />Dermal chromatophore– found in the dermis of the skin, retina, choroid and iris of eyeball<br />Epidermal melanocytes, found in common mole and are responsible for the manufacture of melanin granules<br />
  24. 24. Blood Leukocytes<br />
  25. 25. Lymphocytes<br />Smallest, with rounded nucleus which occupies most of the cytoplasm<br />Concerned with antibody production<br />
  26. 26. Eosinophils<br />Have bilobed nucleus with spherical, darkly staining acidophilic granules<br />Found abundant in lactating breasts, respiratory and alimentary tracts, and in certain allergic reactions<br />
  27. 27. Neutrophils<br />First line of defense, seen in regions of acute inflammation<br />Have a segmented nucleus (3-5 lobes) having fine granules which are purple or violet in color<br />
  28. 28. Monocytes<br />Largest, they have a kidney-shaped nucleus and are considered as the phagocytes of the blood<br />
  29. 29. Connective tissue cells<br />
  30. 30. Ground Substance<br />
  31. 31. Ground substance<br />Colorless, transparent and homogenous<br />Fills the space between cells and fibers of the CT<br />It is viscous and acts as lubricant and also as a barrier to the penetration of the tissues by foreign particles<br />Formed mainly by two classes of components:<br />Glycosaminoglycans<br />Structural glycoproteins<br />
  32. 32. Connective Tissue Fibers<br />Collagen formed by the protein collagen, <br />Reticular most abundant protein of the body<br />Elastic – composed mainly of the protein elastin<br />
  33. 33. Collagen fibers<br />Most numerous fiber in CT<br />Fibers are colorless stands, but when present in great numbers, they cause the tissue in which it lie to be white<br />Are inelastic and have a tensile strength greater than steel<br />Imparts a unique combination of flexibility and strength to the tissues in which it lies<br />
  34. 34. Collagen fibers<br />Consists of closely packed thick fibrils with an average diameter of 75 nm<br />In many parts of the body, are organized in parallel array forming collagen bundles<br />In H & E sections, large or small bundles of fibrils or individual fibrils exhibit acidophilic staining properties<br />
  35. 35. Types of Collages fibers<br />Collagen type I<br />Most abundant and has a widespread distribution (90% of the collagen in the body)<br />Found in the dermis of the skin, tendons, bone, teeth and virtually all CT <br />Collagen type II<br />Present mainly in hyaline and elastic cartilage<br />Only very thin fibrils are formed<br />
  36. 36. Types of collagen fibers<br />Collagen type III<br />Often found in association with type I and is probably the major collagenous components of reticular fibers<br />Can copolymerize with other types of collagen<br />Collagen type IV<br />Is the major collagen type in basal lamina<br />Does not form fibrils or fibers<br />Collagen type V<br />Present in fetal membranes and blood vessels and in small amounts in other tissues<br />
  37. 37. Reticular fibers<br />Are extremely thin, with a diameter between 0.5 and 2 μm<br />Not visible in hematoxylin and eosin stains but can be easily stained black by impregnation with silver salts<br />Argyrophilic fibers – affinity to silver salts<br />During embryogenesis, inflammatory processes, and wound healing, most connective tissues have an abundance of reticular fibers, but these are subsequently replaced by regular collagen fibers<br />
  38. 38. Reticular fibers<br />Particularly abundant in smooth muscles, endoneurium, and the framework of hematopoietic organs (e.g. spleen, lymph nodes, red bone marrow) and constitute a network around the cells of parenchymal organs (e.g. liver, kidney, endocrine glands) <br />
  39. 39. Elastic fibers<br />Consists of an albuminoid protein called elastin<br />Range in diameter from 0.1 to 10 µm<br />Histologically contains few charged amino acids so it stains poorly with standard ionic dyes<br />Special stains such as Verhoeff’s stain and Weigert’sResorcin-fushsin stain are used in light microscope<br />Are extremely pliable and elastic <br />Can be stretched to 150% of their length without breaking and then return to their original length<br />
  40. 40. Elastic fibers<br />Found where their mechanical properties are necessary to allow tissues to stretch or expand and then return to their original shape, e.g. in arterial walls, interalveolar septa, bronchi and brionchioles of the lungs, vocal ligaments and ligamentaflava of the vertebral column<br />
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