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  • 1. Renewable Diesel made from Sugar Cane Adilson Liebsch Product Marketing Amyris Brasil October 2010 CONFIDENTIAL [1]
  • 2. Agenda !  Corporate Overview !  Technology !  Renewable Products – Diesel de Cana !  Manufacturing and scale-up !  Cost of Amyris Diesel CONFIDENTIAL [2]
  • 3. Amyris Renewable fuels and chemicals for a sustainable world CONFIDENTIAL [3]
  • 4. Business Model TECHNOLOGY MANUFACTURING PRODUCTS •  Pioneering technology •  Access to lowest cost •  No Compromise® fuels platform capable of making feedstock (first sugarcane, •  Family of renewable >50,000 molecules then cellulosic) chemicals •  Engineer yeast to convert •  Lowest carbon footprint •  Anti-malarial ingredient sugar into hydrocarbons •  Owned and 3rd party (non-profit initiative) production assets Integrated renewable products company CONFIDENTIAL [4]
  • 5. Our vision: Enable a bio-based economy… Traditional oil source Wide range of possible products + = Petroleum products Anti-malaria drug non-profit: treat over 200 million people annually Oil Refinery Bio-derived products Chemicals: Amyris engineered yeast in fermentation e.g. solvents, formulation ingredients for home care and personal care, polymers, lubricants, F&F, etc. + = Access to + > 50,000 isoprenoid compounds Diesel Amyris genetically Sugar cane engineered yeast Cane mill Jet fuel CONFIDENTIAL [5]
  • 6. Amyris today... Chicago, Illinois •  Amyris Fuels LLC •  Renewable fuels Europe marketing and distribution •  Anti-malarial partnership with sanofi-aventis Alabama Emeryville, California •  sugar cane •  ABI headquarters nursery project •  labs, pilot plant Campinas, Brazil Pradópolis, Brazil •  Amyris Brasil S.A. •  SMA S.A. •  labs, pilot plant & •  JV with São Martinho demo facility •  Commercial scale production in 2012 … combining great science and innovative business to create a more sustainable world CONFIDENTIAL [6]
  • 7. Why Brazil? 2007 Production cost US$ per gallon Feedstock Brazil 0,87 cane US 1,61 corn EU 1,97 wheat China 1,80 corn Source: McKinsey & Company CONFIDENTIAL [7]
  • 8. Agenda !  Corporate Overview !  Technology !  Renewable Products – Diesel de Cana !  Manufacturing and scale-up !  Cost of Amyris Diesel CONFIDENTIAL [8]
  • 9. Platform Delivers Multiple Products Artemisinic Acid Anti-Malarial Drug Sugar Syrup p450 YEAST CELL CPR Mevalonate Pathway ADS Diesel & Chemical Precursor Farnesene Synthase X GPPS Farnesene IS PS Ethanol Isoprene Jet / Gasoline Precursors CONFIDENTIAL [9]
  • 10. Engineered Microbes Convert Sugar to Hydrocarbons Amyris Engineered Yeast Amyris Farnesene (Diesel Precursor) Phase-Contrast Micrograph of Amyris Engineered Microbes Producing Farnesene" CONFIDENTIAL [ 10 ]
  • 11. Agenda !  Corporate Overview !  Technology !  Renewable Products – Diesel de Cana !  Manufacturing and scale-up !  Cost of Amyris Diesel CONFIDENTIAL [ 11 ]
  • 12. Producing High-Value Products through Low-Cost Fermentation CHEMICAL FINISHING Diesel Fuel Jet Fuel Surfactants Farnesene Lubricants Cosmetics, Flavors and Fragrances FERMENTATION CHEMICAL Plastics AT MILLS BUILDING BLOCK Additives CONFIDENTIAL [ 12 ]
  • 13. 2012 and Beyond – Partners and Customers in Place AMYRIS BIOFENE® FINAL TESTING IN AMYRIS BIOFENE® IN PET BOTTLES MAJOR P&G PRODUCT AMYRIS DIESEL WINS INTERNATIONAL AMYRIS JET FUEL SELECTED FOR COMPETITION TEST FLIGHT CONFIDENTIAL [ 13 ]
  • 14. Diesel de Cana: a fuel with “drop in” properties... A hydrocarbon C15H32 Lubricity (HFRR)= 330um No Sulfur Blends up to 35% of Sugar Cane Diesel are approved for commercial use in the United States. •  Amyris diesel will be used in blends with conventional fuels; values shown for Amyris diesel is for our biomass derived blending component CONFIDENTIAL [ 14 ]
  • 15. Performance – Mercedes OM 924 (Brazil) Fuel: Sugar Cane Diesel 10% + Diesel Euro III + 4% Biodiesel -  No performance difference between Sugar Cane Diesel, Diesel S500 and ANP32/2007 -  Torque -  Power -  Fuel consumption (BSFC) -  Engine control parameters were not affected by the use of the blend. CONFIDENTIAL [ 15 ]
  • 16. Emissions on a Mercedes OM 924 engine 10% Sugar Cane Diesel + Euro III Diesel + 4% Biodiesel: -  9% reduction in Particulate Matter emissions, when compared to 500PPM sulfur Diesel . -  No changes observed on other regulated gasses. OM 924 CONFIDENTIAL [ 16 ]
  • 17. Teste de Frota São Paulo Frota: •  3 10% AMD + Diesel B S50 (5% Biodiesel) •  3 Diesel B5 S50 (5% Biodiesel) para referência Teste de Frota SPTrans Km acumulada esperada: •  100.000km Parâmetros a serem monitorados: •  Consumo de combustível/óleo lubrificante •  Contaminação óleo •  Emissões (Opacidade) •  Durabilidade dos componentes de motor e veículo •  Performance dos veículos ( percepção de motoristas) •  Características de manuseio do combustível (transporte, mistura & armazenamento) Duração prevista: •  6 meses (Julho – Dezembro 2010) Local: •  Região Metropolitana de São Paulo em rotas representativas. CONFIDENTIAL [ 17 ]
  • 18. Teste de Frota SPTrans – 10% Diesel de Cana ( resultados Intermediários = 3 meses) Sem impacto em Consumo Com redução em Opacidade... e Operação Idêntica CONFIDENTIAL [ 18 ]
  • 19. “Well-to-wheel” Green House Gasses reduction... Amyris Diesel shows a reduction in GHG’s, even vs. sugarcane ethanol… Life-cycle GHG Emissions (g/MJ) 100,0 80,0 >90% 60,0 reduction 40,0 20,0 0,0 Petroleum Sugarcane Corn EtOH Petroleum Amyris Gasoline EtOH (US) Diesel Diesel (Brazil) (Brazil) CONFIDENTIAL [ 19 ]
  • 20. Agenda !  Corporate Overview !  Technology !  Renewable Products – Diesel de Cana !  Manufacturing and scale-up !  Cost of Amyris Diesel CONFIDENTIAL [ 20 ]
  • 21. Production Process – Conversion of Existing mills The “Crush” Fermentation Dehydration Purification •  Engineered •  This stage not •  Inexpensive yeast required process to •  Modified because remove low- fermenters hydrocarbons level impurities separate easily from water Biomass Fermentation Recovery Purification Dehydration Processing (Stomach) (Stomach) (Stomach) (Stomach) (Mouth) Cellulose Production and Purification Processing Chemical (Muscle) Finishing Cogen, Steam, etc Finishing •  Chemical step converts precursor into fuel CONFIDENTIAL [ 21 ]
  • 22. Amyris “Capital-Light” Industrial-Scale Production Usina São Martinho Mill Pradópolis, Brazil “Bolt-On” Investment CONFIDENTIAL [ 22 ]
  • 23. Production timeline 2009 2010-2011 2012 2013 R&D center inaugurated Begin conversion of first First large scale First commercial in Campinas, Brazil mill to produce Amyris production of Amyris production by third renewable products renewable products party mills Q2: Brazil pilot plant at first mill operational; selected EPCM and commenced Continue mill commercial plant conversion and engineering & design expansion at other mills Q3: Brazil Demo Facility operational Q4: Signed agreements with Brazilian mill owners for feedstock and production access CONFIDENTIAL [ 23 ]
  • 24. Agenda !  Corporate Overview !  Technology !  Renewable Products !  Manufacturing and scale-up !  Cost of Amyris Diesel CONFIDENTIAL [ 24 ]
  • 25. Path to competitiveness... Scale (tsd m3/year) Amyris Diesel Cost level Current Biodiesel Cost Level Diesel Cost Level Productivity (Kg Diesel de Cana/(kg sugar x day)) Time CONFIDENTIAL [ 25 ]
  • 26. A Track Record of Lower Production Costs Peak Farnesene Yield Farnesene Titer (g/L) 16,8% 104,3 6,3% 11,7 Dec 2008 Current Dec 2008 Current Farnesene Productivity (g/L/d) Farnesene Recovery (%) 16,9 95% 40% 0,85 Dec 2008 Current Dec 2008 Current CONFIDENTIAL [ 26 ]
  • 27. Cost dinamics similar to Ethanol - Feedstock is the main driver ! CONFIDENTIAL [ 27 ]
  • 28. Brazilian AMD Certification Process 2009 2010 2011 2012 2013 ! Characterization ! Fuel sys durability 5% Fuel sys durability 100% ! Performance & Emissions SPTRANS Fleet test OEMs engine testing for warranty purposes FETRANSPOR Fleet test 2nd SPTrANS Fleet test Commercial ANP experimental use authorization production Regulatory ( <100k liters/month) ANP specific use authorization ( >100k liters/month) Government policies definition ( Cane Diesel as part of Brazilian energy matrix) CONFIDENTIAL [ 28 ]
  • 29. Thanks !! Adilson Liebsch liebsch@amyris.com CONFIDENTIAL [ 29 ]
  • 30. Atendimento à especificação 1/3 (Puro) CONFIDENTIAL [ 30 ]
  • 31. Atendimento à especificação 2/3 (Misturas) CONFIDENTIAL [ 31 ]
  • 32. Atendimento à especificação 3/3 (Misturas) CONFIDENTIAL [ 32 ]