Life Science Network of the State of Niedersachsen…
… .. and is coordinating the initiative „Life Science Niedersachsen goes India“ under the umbrella of the research marketing campaign of the German Federal Ministry of Education and Research.
Vaccines - Global Needs, Global Markets Highly unmet medical needs: The BIG Three: HIV, Tuberculosis, Malaria. Diarrhea causing diseases. Hepatitis C. Cytomegalovirus. Dengue. Influenza. Cancer. Other diseases related to infections or immune system disorder. Corvay at BioAsia2009
Vaccines - Global Needs, Global Markets 21 bn USD global vaccine sales in 2008 (18.5 bn USD in 2007). Prevnar® 3bn USD; Gardasil 2.8 bn USD. Several others >1 bn. “ Classical” mainly pediatric market 6 – 7 bn USD, stable. New vaccines providing the growth. India: 1800 crores = approx 360 mill USD. Russia, Brazil, China, all South East Asia to become big markets. Corvay at BioAsia2009
Vaccines - Global Needs, Global Markets Another urgent need : In order to grow further , industry needs new, successful candidates. Corvay at BioAsia2009
Corvay at BioAsia2009 Where do new vaccine concepts come from ?
HPV vaccine invented by 2008 nobel laureate Prof. zur Hausen, DKFZ, German Cancer Research Center.
Diphteria serum treatment (1901) by Emil von Behring at Marburg university, later funded by Hoechst.
- Many others.
Industry, in earlier times national serum institutes.
Corvay at BioAsia2009 Situation in German academia 1995 - 2000
Prospering science scene with >200 research projects in > 50 scientific groups.
Productive collaboration between science and industry, mainly Behringwerke, sold to Chiron in 1996.
Working group in the Federal Ministry of Education and Research on how to foster commercialization if academic vaccine research.
Emil von Behring, 1917
Corvay at BioAsia2009 Bridging the gap between academia and industry
Main hurdle: mentality / incentive systems.
TLO´s (technology licence offices).
licence oriented - several university based TLO´s.
Licence and Spin out oriented – Max Planck Innovation, Ascenion.
Successfull Spin outs: Immatics, CureVac.
Project management company.
New concepts since 2008: Lead Discovery Center, Screening port.
Science Parks, associated to universities and research centers.
Corvay at BioAsia2009 Project Management Company
key principle: partner ! focus on key expertise of each partner.
research / innovation at academic institute (university, Max Planck
Institute, Fraunhofer Institute) -> creative and cost effective.
process development and manufacturing at appropriate CMO,
custom manufacturing organization -> no CapEx !
preclinical trial at appropriate CRO.
clinical trial with appropriate CRO in appropriate endemic area.
all support services (regulatory, patent/IP, quality, legal, HR,
accounting) with expert partners.
product/indication specific advice from selected experts.
plan and manage project „with the final objective in mind“.
Corvay at BioAsia2009 Vakzine Projekt Management GmbH
founded 2002, operative 2003, 5 later 8 FTE´s, based in Hannover.
tuberculosis – recombinant live BCG vaccine.
prostate cancer – recombinant LNCap cell line.
novel interferon-beta Soluferon®, for Multiple Sclerosis.
on the shelf: HCMV dense bodies and Malaria MSP-1.