Eliminating Pediatric HIV/AIDS, and Caring for Children with HIV Dr. Laura Guay Vice President of Research Elizabeth Glaser Pediatric AIDS Foundation IAS 2011 Media Training & Briefing July 16, 2011 Rome, Italy
These tests measure the actual parts of the HIV virus itself (PCR, p24 antigen, viral culture)
These tests can identify HIV infection in a very young baby
WHO’s 4-Component Strategy for MTCT Prevention Prevention of HIV in women, especially young women Prevention of unintended pregnancies in HIV-infected women Prevention of transmission from an HIV- infected woman to her infant Support for HIV-infected women, their infants, and families Component 1 Component 2 Component 3 Component 4
600 000 500 000 400 000 300 000 200 000 100 000 0 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 Year This bar indicates the range New Global HIV Infections among Children, 1990–2007
Provision of Antiretroviral Drugs, 2004-2009 WHO, UNAIDS, UNICEF - Towards Universal Access: Progress Report 2009
Review of Latest Data - 2009 New Global HIV Infections among Children: 370,000 children were infected with HIV – More than 1,000 children EVERY DAY Provision of Antiretroviral Drugs: 53 % of pregnant women living with HIV received ARVs - 47% did NOT 35% of infants born to pregnant women living with HIV received ARVs – 65% did NOT
Benefits of Global Expansion of PMTCT Programs
Provides opportunity for primary prevention for large number of identified HIV-uninfected women
Provides opportunity for prevention of HIV infection in children
Provides opportunity for entry point into HIV Care for large number of HIV-infected women and their infected infants
However, this is often a missed opportunity as ongoing HIV care and treatment is not available
If women with HIV do not take any HIV drugs during pregnancy and they breastfeed - - about 30 out of 100 babies born to these women will get HIV.
Timing of HIV transmission to the infant During pregnancyAround labor/deliveryDuring Breastfeeding
If women and newborns take 1 dose of the drug nevirapine around the time the baby is born - - only ~16 out of 100 babies will getHIV from their mothers.
If women and newborns take a combination of HIV drugs during pregnancy and after delivery - - as few as 4-6 out of 100 babies will get HIV from their mothers.