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Nutrition/ Anti aging

Nutrition/ Anti aging

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  • P332 Figure 5.6

Benetos 1 Benetos 1 Presentation Transcript

  • Athanase Benetos University of Nancy, France Can we slow down the aging process with caloric restriction? 4th International Seminar in Preventive Geriatrics Athens, April 2011
  • (1214-1294) The father of the prolongevity movement “Secret Arts of The Past” Roger Bacon We live short because we live immoral and unhealthy lives
  • Roger Bacon
    • Controlled diet
    • Proper rest
    • Exercise
    • Moderation life style
    • Good hygiene
    • Inhaling the breath of a young virgin
    View slide
  • Is there one or several « anti-aging » diets? View slide
  • Korean team filming how Azeri villagers prepare yogurt. Shirali died at 168 years-old
  • Fish Oils
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  • Mediterranean- Cretian Diet
    • Vital energy with aging
    • The solution : Moderation
    1467-1569 Luigi Cornaro “ The art of living long” “ The Sober life” Eating less
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  • Nutrient caloric intake ‘dose response’ and life span in the lab fly. Life Span, days Food Concentration (x normal) Food Concentration (x normal)
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  • (A) A 19-year-old male rhesus monkey weighing 13.6 kg on the control diet. (B) A 19-year-old male rhesus monkey weighing 7.9 kg on CR for 17 years. (C) A 38-year-old (estimated age) male rhesus monkey weighing 6.8 kg on CR for 17 years. He died 18 April 2004 at a minimal estimated age of 40 years, but he could have been as old as 44 years, making him one of the oldest recorded of this species. Aging in Rhesus Monkeys: Relevance to Human Health Interventions George S. Roth, Julie A. Mattison, Mary Ann Ottinger, Mark E. Chachich, Mark A. Lane, and Donald K. Ingram Science 2004: 1423-1426 .
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  • What Calorie Restriction is? Control group: 2,500 kcal/day, 17% protein, 52% carbohydrates, 31% fat, (11% saturated fat). CR subjects: 1,650 kcal/day (p<0.0001 vs. controls), 23% protein, (p <0.0001 vs. control group), 49% carbohydrates, 28% fat, (6% saturated fat) Daily salt intake was lower in the CR group (2.6 + 1.3g vs. 3.4 + 1.0g; p<0.007).
  • Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans Timothy E. Meyer, PHD St. Louis, Missouri and Rome, Italy JACC Vol. 47, No. 2, 2006
  • Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans Timothy E. Meyer, PHD St. Louis, Missouri and Rome, Italy JACC Vol. 47, No. 2, 2006
  • Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans Timothy E. Meyer, PHD St. Louis, Missouri and Rome, Italy JACC Vol. 47, No. 2, 2006
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  • Data from People on CR
    • 18 persons from the “Caloric Restriction Optimal Nutrition Society”
    • Body fat: Controls = 22%; CR = 7%
    Fontana et al. (2004) PNAS 101 : 6659-63
  • Carotid IMT of the common carotid artery was 40% less in the CR than in the comparison group (P < 0.0001). None of the individuals on CR had evidence of atherosclerotic plaque, defined as an IMT of more than 1.0 mm and an increase of at least 100% compared to an adjacent wall segment Fontana et al. (2004) PNAS 101 : 6659-63
  • Improve your life style
    • Eat better
    • Avoid obesity
    • Make exercise
  • I don ’ t know if life would be longer (if we use CR) but I am sure that life would seem much longer! Jay Olshansky, Chicago