Go Geous - beneficial drink that will definitely awaken even the most weakest of cells.  <br />This exquisite product brin...
Uttwiler Spätlauber (Malus Domestica)- an Apple with an Excellent Storage Ability<br /><ul><li>Storage ability of apples w...
Modern apple cultivars are selected for a sweet flavour and therefore the Uttwiler Spätlauber disappeared
Today the Uttwiler Spätlauber apple is an endangered apple variety with only a few trees left in the world</li></ul>The Se...
High acid and tannin concentrations
Undiscovered metabolites?</li></li></ul><li>Young and Old<br />
Plant Cell Culture Technology (PCT)<br /><ul><li>PCT makes it possible to cultivate cells of endangered and rare species
The technology is based on dedifferentiated plant cells
These cells are plant stem cells and can be cultivated in liquid systems</li></ul>What are Stem Cells? <br /><ul><li>Stem ...
Blastocyst, 4-5 days post fertilization, 50-150 cells
Pluripotent: Differentiate into one of the more than 220 different cell types of an adult body
The use of embryonic stem cells in medicine is discussed controversially</li></ul>Human: Adult Stem Cells (Multipotent)<br...
Generate all thecelltypesoftheorganfromwhichtheyoriginate — potentiallyregeneratingtheentireorganfrom a fewcells
Primary roles: Replenishdyingcellsandregeneratedamagedtissues</li></li></ul><li>Plant Stem CellsFormation of Callus Tissue...
In the callus tissue the normal differentiated cells go back into a dedifferentiated form and become stem cells (not possi...
Mechanism is controlled by different plant hormones (auxins) </li></ul>PhytoCellTecTMbyMibelleBiochemistry<br /><ul><li>Ph...
Only a small quantity of plant material of endangered species is needed
Induction of callus tissue by cutting plant parts
Isolation of stem cells and cultivation on agar plates</li></li></ul><li>FromCallustoPlants<br />PhytoCellTecTM<br /><ul><...
Transformation of the cells into liquid suspension</li></ul>	(1 - 6 months)<br /><ul><li>Find optimal conditions for cell ...
Stem Cells andAging<br /><ul><li>Stem cells are responsible for the rejuvenation
Stem cells are sensitive to environmental threats
Chronological aging leads to the depletion of the number and activity of stem cells</li></ul> Protection of stem cells an...
The epigenetic profile regulates the gene expression in stem cells</li></li></ul><li>Activityof PCT Malus Domestica<br />1...
ProtectionAgainst UV(Umbilical Cord Stem Cells) <br />Day 7<br />Growth of Hair Follicle<br />Day 4<br />Hair follicles 		...
Summary<br />Product from rare Swiss Malus domestica var. Uttwiler Spätlauber <br />PhytoCellTecTM to produce stem cells f...
Increase of activity of stem cells
Decrease of senescence markers in fibroblasts
Increase of life span of hair follicles</li></li></ul><li>Claims<br /><ul><li>Delays senescence of essential cells
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MIRACLE PRODUCT FROM SWISS

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MIRACLE PRODUCT FROM SWISS

  1. 1.
  2. 2. Go Geous - beneficial drink that will definitely awaken even the most weakest of cells. <br />This exquisite product brings to you the secrets of the future so advanced that its formula cannot be compared to any other existing health supplement in the market. <br />Highly efficacious and balanced formulation consist of :<br />PhytoCellTec™ MalusDomestica (Apple Stem Cells), <br />Rousselot Fish Collagen, <br />Acai Berry Extract, <br />Pine Bark Extract, <br />Grape Seed Extract, <br />L-Arginine and Mixed Berries.<br />
  3. 3. Uttwiler Spätlauber (Malus Domestica)- an Apple with an Excellent Storage Ability<br /><ul><li>Storage ability of apples was an important factor to guarantee fresh fruits over winter in the 18th century
  4. 4. Modern apple cultivars are selected for a sweet flavour and therefore the Uttwiler Spätlauber disappeared
  5. 5. Today the Uttwiler Spätlauber apple is an endangered apple variety with only a few trees left in the world</li></ul>The Secret of Storage Ability<br /><ul><li>Longevity of cells
  6. 6. High acid and tannin concentrations
  7. 7. Undiscovered metabolites?</li></li></ul><li>Young and Old<br />
  8. 8. Plant Cell Culture Technology (PCT)<br /><ul><li>PCT makes it possible to cultivate cells of endangered and rare species
  9. 9. The technology is based on dedifferentiated plant cells
  10. 10. These cells are plant stem cells and can be cultivated in liquid systems</li></ul>What are Stem Cells? <br /><ul><li>Stem cells have two properties:</li></ul>Self-renewal - the ability to go through numerous cycles of cell division in an undifferentiated state <br />Differentiation - the capacity to differentiate into other cell types<br /><ul><li>Toti-, pluri-, multi-, unipotent stem cells</li></li></ul><li>Human: Embryonic Stem Cells (Pluripotent)<br /><ul><li>Cells derived from the inner cell mass of an early stage embryo
  11. 11. Blastocyst, 4-5 days post fertilization, 50-150 cells
  12. 12. Pluripotent: Differentiate into one of the more than 220 different cell types of an adult body
  13. 13. The use of embryonic stem cells in medicine is discussed controversially</li></ul>Human: Adult Stem Cells (Multipotent)<br /><ul><li>Undifferentiatedcellsamongdifferentiatedcells in a tissueororgan
  14. 14. Generate all thecelltypesoftheorganfromwhichtheyoriginate — potentiallyregeneratingtheentireorganfrom a fewcells
  15. 15. Primary roles: Replenishdyingcellsandregeneratedamagedtissues</li></li></ul><li>Plant Stem CellsFormation of Callus Tissue <br /><ul><li>If a plant is wounded, a callus tissue is formed (wound healing tissue)
  16. 16. In the callus tissue the normal differentiated cells go back into a dedifferentiated form and become stem cells (not possible in humans)
  17. 17. Mechanism is controlled by different plant hormones (auxins) </li></ul>PhytoCellTecTMbyMibelleBiochemistry<br /><ul><li>PhytoCellTecTMutilizes this unique totipotency of plant cells
  18. 18. Only a small quantity of plant material of endangered species is needed
  19. 19. Induction of callus tissue by cutting plant parts
  20. 20. Isolation of stem cells and cultivation on agar plates</li></li></ul><li>FromCallustoPlants<br />PhytoCellTecTM<br /><ul><li>Complete dedifferentiation of the cells into a homogenous culture (4 -12 months)
  21. 21. Transformation of the cells into liquid suspension</li></ul> (1 - 6 months)<br /><ul><li>Find optimal conditions for cell cultivation</li></ul> (1 - 6 months)<br />
  22. 22. Stem Cells andAging<br /><ul><li>Stem cells are responsible for the rejuvenation
  23. 23. Stem cells are sensitive to environmental threats
  24. 24. Chronological aging leads to the depletion of the number and activity of stem cells</li></ul> Protection of stem cells and activation of stem cell function is of great importance in our body<br />EpigeneticFactors in Stem Cells<br /><ul><li>Normal differentiated cells express only a limited amount of genes</li></ul> (fibroblast: collagen; blood cells: hemoglobin)<br /><ul><li>Stem cells have the possibility to express the whole DNA
  25. 25. The epigenetic profile regulates the gene expression in stem cells</li></li></ul><li>Activityof PCT Malus Domestica<br />1. Use of plant stem cells to protect stem cells<br />The components of Malusdomestica stem cells are rich in epigenetic factors relevant to protect and maintain the function of skin stem cells. <br />2. Use of plant metabolites to delay senescence<br />The active ingredients of Malusdomestica var. UttwilerSpätlauber cells contain metabolites which insure longevity of cells. <br />Study Results<br />Increase in Cell Number (Human Umbilical Cord Stem Cells) <br />
  26. 26. ProtectionAgainst UV(Umbilical Cord Stem Cells) <br />Day 7<br />Growth of Hair Follicle<br />Day 4<br />Hair follicles From human skin fragments (from micro dissection)<br />Test substance PhytoCellTecTMMalusDomestica 0.2%<br />Design Length of hair follicle increases until day 14 <br />-> after day 14 induction of senescence<br />-> length of hair follicle decreases<br />Day 0<br />
  27. 27. Summary<br />Product from rare Swiss Malus domestica var. Uttwiler Spätlauber <br />PhytoCellTecTM to produce stem cells from this apple<br />Product activity<br />1. Activation and protection of stem cells<br /> 2. Delay of senescence<br />Results show<br /><ul><li>Protection of stem cells against UV-radiation
  28. 28. Increase of activity of stem cells
  29. 29. Decrease of senescence markers in fibroblasts
  30. 30. Increase of life span of hair follicles</li></li></ul><li>Claims<br /><ul><li>Delays senescence of essential cells
  31. 31. Protects longevity of stem cells
  32. 32. Protection of stem cells
  33. 33. Rejuvenation of cells
  34. 34. Maintains the power of regeneration
  35. 35. Combats chronological aging</li></ul>Properties of PhytoCellTecTM<br /><ul><li>PhytoCellTecTM is a preparation of plant stem cells
  36. 36. PhytoCellTecTM is produced in Switzerland by a novel plant cell culture technology
  37. 37. PhytoCellTecTM contains plant stem cells to protect and maintain stem cells
  38. 38. The protection of stem cells is a breakthrough approach in anti-aging
  39. 39. Studies showed that PhytoCellTecTM protects human stem cells and rejuvenates them
  40. 40. PhytoCellTecTM delays chronological aging</li></li></ul><li>PhytoCellTec™ MalusDemestica - Benefits<br /><ul><li>PhytoCellTecTM plant stem cells are a breakthrough in anti-aging therapy
  41. 41. Stem cell treatment is a revolutionary new approach in healthcare industry
  42. 42. Plant stem cells are extremely efficient but also safe to use
  43. 43. PhytoCellTecTM is based on real plant stem cells to trigger the rejuvenation of the body
  44. 44. PhytoCellTecTM delays the natural aging process by maintaining the activity of stem cells</li></li></ul><li>
  45. 45. According to the US edition of Vogue, the First Lady buys a £215 serum which uses an extract from stem cells of the UttwillerSpattauber apple<br />
  46. 46. Rousselot™ Fish Hydrolyzed Collagen<br />Rousselot™ Hydrolyzed Collagen are natural proteins, derived from the collagen found in fish skins and bones.<br />Some definitions of Collagen<br />Chemistry and Biology of proteins-<br />F.Haurowitz<br />Academic Press, Inc. – New York,1950<br />“…a structural protein of connective tissues and composes the larger part of the tendons, ligaments…(and)… a portion of the bones, cartilage and skins..”<br />Merriam Webster Dictionary<br />“…an insoluble fibrous protein that occurs in vertebrates as the chief constituent of connective tissue fibrils and in bones…<br />
  47. 47. Rousselot™ Fish Hydrolyzed Collagen<br />Rousselot™ Hydrolyzed Collagen is 92% pure protein made of all essential amino-acids, particularly rich in alanine, arginine, glycine, glutamic acid and proline.<br />Alanine*: Involved in the supply of energy to muscle tissues, brain and central nervous system, alanine plays a role in the metabolism of sugars and organic acids. It strengthens the immune system through its effect on antibody production. <br />Arginine*: Useful for immune system stimulation, arginine is involved in the wound healing process and the secretion of hormones. <br />Glutamic Acid*: An important excitatory neurotransmitter, glutamic acid helps speed the healing of ulcers and gives relief from fatigue. <br />Glycine*: Beside its nutrient role for a strong immune system, glycine triggers the release of the oxygen required by the cell-making process. It is also a fast inhibitory neurotransmitter. <br />Proline*: Important for joints and tendons adequate functioning, proline participates in heart muscle strengthening. <br />*Non-essential amino-acid. <br />
  48. 48. Rousselot™ Fish Hydrolyzed Collagen – Clinical Studies<br />Comprehensive clinical studies carried out in Japan and France confirm the effect of taking Rousselot™ Hydrolyzed Collagen on skin health.<br />Background :<br />Fine lines, wrinkles, and loss of elasticity are symptoms commonly associated with aging skin. Accumulated environmental <br />exposure and a natural decrease in cell renewal contribute to other signs less often associated with aging: dull, rough, or dry skin.<br />The latest investigative studies using state-of-the-art technology have challenged the effect of Rousselot™ Hydrolyzed Collagen. Two clinical studies were carried out by global independent skin health research organizations having a well <br />proven approach for verifying product performance claims. Mechanical measurements and volunteers were assessed by certified skin experts. <br />Conclusion <br />These two clinical studies demonstrated the benefits of Rousselot™ on skin health. <br />Taken daily, up to 12 weeks, the results verify that regular intake of Rousslet™ Hydrolyzed Collagen improves the basic skin condition and structure. <br />Rousslet™ Hydrolyzed Collagen has clinically shown to: <br />Improve skin moisture level <br />Improve skin smoothness by reducing the number of micro-relief furrows <br />Prevent the formation of deep-wrinkles <br />Improve skin suppleness <br />Rousslet™ Hydrolyzed Collagen, a completely characterized and scientifically objectivized natural bioactive ingredient that improves epidermis moisture content and prevents skin aging.<br />
  49. 49. Acai Berry<br />The Acai (ah-sigh-ee) Berry has been around for thousands of years and not until the 1990's was it introduced to the western world. The acai berry was found to possess tremendous health properties. The acai berry was first used by the tribes of the Amazon jungle as a cure for various ailments.<br />The acai berry was discovered to have natural antioxidant properties, as well as being a natural cholesterol controller. When eaten it helps reduce the bad cholesterol in our blood and increases the good cholesterol. The tribes of the Amazon knew of these properties and found out that it helped build the immune system, fight infection, protect the heart, and control prostate enlargement (nature's viagra). It was a great energy food for the tribes-people.<br />
  50. 50. Acai Berry - Benefits<br /><ul><li>A remarkable concentration of antioxidants that help combat premature aging, with 10 times more antioxidants than red grapes and 10 to 30 times the anthocyanins of red wine.
  51. 51. An almost perfect essential amino acid complex in conjunction with valuable trace minerals, vital to proper muscle contraction and regeneration.
  52. 52. The fatty acid content in açaí resembles that of olive oil, and is rich in monounsaturated oleic acid. Oleic acid is important for a number of reasons: </li></ul>It helps omega-3 fish oils penetrate the cell membrane; together they help make cell membranes more supple. By keeping the cell membrane supple, all hormones, neurotransmitter and insulin receptors function more efficiently. This is particularly important because high insulin levels create an inflammatory state, and we know, inflammation causes aging.<br />Acai Berry does contain Omega-3 fatty acids, Omega-6 and Omega-9. Each of these can lower the so-called bad cholesterol, or LDL, and each can maintain our HDL, or good cholesterol.<br />
  53. 53. Weight loss - One of the most desirable benefits of Acai Berry supplements weight loss. With Acai Balance you can flush up to 25 pounds of waste and toxins.<br />Increases Energy- Our active lifestyles leave us drained of energy. Many of us don’t get enough sleep, and we walk around all day like zombies. This creates serious long-term medical conditions. Thankfully, Acai Berry helps improve your overall energy. You can rest better, and wake up more refreshed in the morning. Acai Balance is especially effective at boosting your metabolism.<br />Improves Blood Flow- Poor circulation can lead to numerous medical conditions (clotting, balding, and heart issues.) Acai Berry supplements work to improve your blood flow, thus staving off many serious ailments. Improved circulation makes you feel better and live longer. <br />Healthier Skin- The berry contains many unique properties that work to make your skin look and feel younger. <br />Stronger Heart- Heart disease is one of the leading causes of death in America. From lack of exercise to poor dietary habits, our hearts endure a lot of stress. Acai Berry supplements give your heart the nutrients it needs to work properly.<br />Better Concentration- Another of the seemingly endless benefits of Acai Berry is the improved mental clarity it produces. In a way, this goes back to the circulation benefits. With better blood flow, your brain is able to operate more efficiently.<br />Reduced Cholesterol- When you think of lowering your cholesterol, you probably recall images of eating healthy foods that taste terrible. Acai Berry supplements save you the trouble of eating tasteless oats. This berry will lower your cholesterol significantly over time.<br />Detoxifies Body- Acai Berry contains several antioxidants that work to eliminate harmful substances from your body. Throughout our life, our body absorbs many damaging substances. Acai Berry works to eradicate them, and to make your immune system stronger than ever before.<br />Enhances Sexual Performance- Do I really need to explain why this is beneficial?<br />Acai Berry – OtherBenefits<br />Weight loss- Increases the metabolism in the body, which helps in reducing the unwanted fats from the body.<br />Increases Energy-Our active lifestyles leave us drained of energy. Many of us don’t get enough sleep, and we walk around all day like zombies. This creates serious long-term medical conditions. Thankfully, Acai Berry helps improve your overall energy. You can rest better, and wake up more refreshed in the morning. <br />Improves Blood Flow- Poor circulation can lead to numerous medical conditions (clotting, balding, and heart issues.) Acai Berry supplements work to improve your blood flow, thus staving off many serious ailments. Improved circulation makes you feel better and live longer. <br />Stronger Heart- Heart disease is one of the leading causes of death in America. From lack of exercise to poor dietary habits, our hearts endure a lot of stress. Acai Berry supplements give your heart the nutrients it needs to work properly.<br />Better Concentration- Another of the seemingly endless benefits of Acai Berry is the improved mental clarity it produces. In a way, this goes back to the circulation benefits. With better blood flow, your brain is able to operate more efficiently.<br />Healthier Skin- The berry contains many unique properties that work to make your skin look and feel younger. <br />Reduced Cholesterol- When you think of lowering your cholesterol, you probably recall images of eating healthy foods that taste terrible. Acai Berry supplements save you the trouble of eating tasteless oats. This berry will lower your cholesterol significantly over time.<br />Detoxifies Body- Acai Berry contains several antioxidants that work to eliminate harmful substances from your body. Throughout our life, our body absorbs many damaging substances. Acai Berry works to eradicate them, and to make your immune system stronger than ever before.<br />Enhances Sexual Performance- Known as Viagra of Amazon<br />
  54. 54. Pine Bark Extract<br />Pine bark extract is made from the bark of a European coastal pine tree called the Landes or maritime pine, whose scientific name is Pinusmaritima.<br />Researchers have termed the group of antioxidants found in pine bark extract oligomericproanthocyanidins, or OPCs for short. OPCs (also referred to as PCOs) are some of the most powerful antioxidants available.<br />Antioxidants play a key role of repairing and protecting cells in the body. They help protect against free radicals, which are damaging byproducts of metabolism and exposure to environmental pollutants. Free radical damage is believed to contribute to aging, as well as too severe conditions including heart disease and cancer.<br />Much research has been conducted on OPCs and on pine bark extract. In France, pine bark extract and OPCs have been rigorously tested for safety and effectiveness, and pine bark extract is a registered drug.<br />
  55. 55. Pine Bark Extract<br />Pine bark extract has been shown to contain a powerful antioxidant that helps protect cells from free radical damage and increases the effectiveness of vitamin C. <br />Pine bark extract has been shown to help lower cholesterol, and to decrease the risk and severity of atherosclerosis, or damage to the arteries. It has been demonstrated to help strengthen and repair tissues made of collagen, a protein that builds blood vessels, skin, and connective tissue.<br />The OPCs in pine bark extract have also been shown to help reduce swelling and inflammation in the body.<br />Pine Bark Extract - Benefits<br />Pine bark extract is used to reduce the risk and severity of heart disease, strokes, high cholesterol, and circulation problems. <br />It is used in the nutritional treatment of varicose veins and oedema, which is swelling in the body due to fluid retention and leakage of blood vessels.<br />Arthritis and inflammation have also been improved in studies using pine bark extract, as well as the uncomfortable symptoms of PMS and menopause. <br />
  56. 56. Pine Bark Extract - Benefits<br />The OPCs in pine bark extract are recommended for various eye conditions that are caused by blood vessel damage, such as diabetic retinopathy and macular degeneration. <br />Pine bark extract is recommended to improve the health and smoothness of the skin, including damage caused by overexposure to sunlight. <br />Pine bark extract is a supplement used for anti-aging and preventive care as well.<br />Grape Seed Extract <br />Grape Seed Extract (GSE) is a natural plant constituent (bioflavonoid) which strengthens and protects living tissue. The OligomericProanthocyanidins(OPC) components in GSE are 50 times stronger than Vitamin E and 20 times stronger than Vitamin C. <br />Grape Seed Extract is an antiallergenic, antihistamine, anti-inflammatory, and antioxidant. It strengthens blood vessels, improves skin, and aids in circulation.<br />
  57. 57. Grape Seed Extract <br />Grape Seed Extract is prescribed by doctors in several European countries for the prevention and treatment of a variety of health problems including cardiovascular disease, varicose veins, water retention, collagen damage and arthritis. Because it is used pharmaceutically, it has undergone a tremendous amount of testing.<br />Grape Seed Extract is an extraordinarily safe and effective nutritional supplement.<br />Grape Seed Extract provides cardiovascular protection by preventing oxidation of lipoproteins (LDL), making them less likely to stick to blood-vessel walls. <br />It also makes the linings of the arteries more resistant to damage and helps control excessive clotting. <br />GSE strengthens the capillaries ensuring a good supply of oxygen and nutrients to the brain and throughout the body. It also affects enzymes that influence blood-fluid balances and therefore may be helpful in lowering blood pressure.<br />
  58. 58. Recently, researchers discovered that Grape Seed Extract can help to stimulate healthy hair growth by defeating the hormone dihydrotestosterone (DHT) that stops the hair follicle growth cycle.<br />Grape Seed Extract - Benefits <br />
  59. 59. L - Arginine<br />L-Arginine Could Be A Magic Bullet In Anti-Aging Arsenal<br />Columbia University refers to L-arginine as the "magic bullet" for the cardiovascular system<br />Properties of L-arginine were validated by the 1998 Nobel Prize in Medicine, and since then have created a frenzy of interest in the Pharmaceutical and Nutraceutical fields.<br />Medical researchers have gathered enough clinical evidence to bring L-arginine to the forefront of modern medicine as an accepted treatment for a variety of human ailments. The L-argininephenomen is changing standard treatment methodologies in heart disease, immune function, adiposity-generated diseases, genetic growth deficiencies, high blood pressure, sexual disfunction, and human aging.<br />The efficacy of L-arginine as a therapeutic agent has been validated by thousands of clinical studies.<br />The benefits and functions attributed to oral ingestion of L-arginine include:<br /><ul><li> Precursor for the synthesis of Nitric Oxide (NO)
  60. 60. Stimulation of the release of the most important anti-aging hormone in the body; growth hormone.
  61. 61. Improves immune function</li></li></ul><li>L – Arginine - Benefits<br /><ul><li>Reduces risk of heart disease
  62. 62. Natural Alternative to Viagra
  63. 63. Increases muscle mass
  64. 64. Reduces adipose tissue body fat
  65. 65. Helps improve insulin sensitivity
  66. 66. Helps decrease blood pressure
  67. 67. Alleviates male infertility, improving sperm production and motility</li></ul>Obesity is characterized by increased levels of insulin (high glycemic foods and drinks) and by subnormal growth hormone (GH) release. <br />Insulin promotes fat and carbohydrate storage while GH stimulates lipolysis (fat-burning). The insulin/growth hormone ratio is significantly higher in obese humans than in lean humans. <br />The combination of high insulin and low GH exacerbates the obese condition. L-arginine is the main oral agent responsible for restoration of GH in humans, and administration of L-arginine taken at bedtime on an empty stomach 30 minutes prior to Delta sleep reinstates normal GH levels.<br />
  68. 68. Mixed Berries – Strawberry, Bilberry, Raspberry, Elderberry, Blackcurrant, Red Beet <br />They’re loaded with fiber, which helps you feel full (and eat less). <br />Top the charts in antioxidant power, protecting your body against inflammation and free radicals, molecules that can damage cells and organs.<br />A recent study even showed that one-half to one cup of mixed berries a day improved cognition and motor performance in animals. <br />James Joseph, PhD, director of the Neuroscience Lab at the United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, which conducted the study, notes that we become more susceptible to the damaging effects of free radicals and inflammation as we age.<br />Berries help prevent those effects by turning off the inflammation signals triggered by cytokines and COX-2s, making them an ideal part of your diet<br />

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