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presentation of research about Caries, Binahong, antimicrobial agent. Background: Dental caries is one of the most common oral infectious disease happens in all levels of society that one cause is Streptococcus mutans. According to the Household Health Survey (Survey), 2004, dental caries is an oral health problem in Indonesia with a prevalence of 90.05%. Purpose: Binahong is a medicinal plant that contains antimicrobial agent. Expected, Binahong as an alternative medicinal can reduce the incidence of caries in the community. Result: The research method is experimental with CRD (completely randomized design). MIC from Binahong on S. mutans at concentration of 25% and MBC in 50%. Measurement of inhibition on agar diffusion is 10.75 mm. Conclusion: Binahong extract has antibacterial agent against S. mutans. The higher concentration, more pressing the growth of bacteria.