Bioengineering Approaches for Regenerating Organs and Fighting Cancer
Upcoming SlideShare
Loading in...5
×
 

Like this? Share it with your network

Share

Bioengineering Approaches for Regenerating Organs and Fighting Cancer

on

  • 399 views

I will present a basic overview of biomaterials for 1) tissue engineering and 2) cancer therapeutics.

I will present a basic overview of biomaterials for 1) tissue engineering and 2) cancer therapeutics.

Statistics

Views

Total Views
399
Views on SlideShare
398
Embed Views
1

Actions

Likes
1
Downloads
17
Comments
0

1 Embed 1

http://www.slashdocs.com 1

Accessibility

Categories

Upload Details

Uploaded via as Adobe PDF

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

Bioengineering Approaches for Regenerating Organs and Fighting Cancer Presentation Transcript

  • 1. Bioengineering Approaches for Regenerating Organs and Fighting Cancer Erik Reinertsen UCLA BioengineeringFriday, March 9, 12
  • 2. Three topics 1. The father of biomaterials 2. Tissue engineering 3. Cancer therapeuticsFriday, March 9, 12
  • 3. Robert Langerwww.cornell.eduFriday, March 9, 12
  • 4. GliadelFriday, March 9, 12
  • 5. Three topics 1. The father of biomaterials 2. Tissue engineering 3. Cancer therapeuticsFriday, March 9, 12
  • 6. Engineering tissues & organsFriday, March 9, 12
  • 7. Engineering tissues & organsLanger R, Vacanti K. Science (1993)Friday, March 9, 12
  • 8. Tissue engineering could address organ shortageswww.mdconsult.comFriday, March 9, 12
  • 9. In vivo-like platforms for pharmaceutical testingFriday, March 9, 12
  • 10. Huge potential in tissue engineering + stem cellswww.mdconsult.comFriday, March 9, 12
  • 11. Stem cell therapies could help millions of patients Cardiovascular diseases Autoimmune diseases Diabetes Osteoporosis Cancer Alzheimers disease Parkinsons disease Other 0 20 40 60 Millions of peoplePerry D. Science (2000)Friday, March 9, 12
  • 12. Scaffolds engineered from biocompatible polymers PLGA1 PCL2 Collagen31. www.techno-isel.com2. Wu Lab, UCLA Department of Bioengineering3. www.pharmainfo.netFriday, March 9, 12
  • 13. Biochemical signalsLutolf M., Hubbell J. Nature Biotechnology (2005)Friday, March 9, 12
  • 14. Physical signals MSC morphology changes with elasticityEngler A. Cell (2006)Friday, March 9, 12
  • 15. Fibroblasts spread more in lower fibrin concentration 5 mg/mL 10 mg/mL 20 mg/mL Day 1 500 um 500 um 1 mm Day 4 500 um 500 um 500 um Day 7 500 um 500 um 500 umReinertsen E., Tawil B., Wu B.M. Tissue Engineering (submitted)Friday, March 9, 12
  • 16. Cell viability is limited by oxygen transportDemol et al. Biomaterials (2010)Friday, March 9, 12
  • 17. 3D printing offers novel methods of shape controlFriday, March 9, 12
  • 18. Three topics 1. The father of biomaterials 2. Tissue engineering 3. Cancer therapeuticsFriday, March 9, 12
  • 19. Cancer is the #1 killer in the worldwww.tgrbio.comFriday, March 9, 12
  • 20. Cancer is the #1 killer in the world Worldwide -7.6 million deaths In the US alone -1.5 million cases -600,000 deathswww.who.int/mediawww.cdc.gov/nchs/fastats/lcod.htmFriday, March 9, 12
  • 21. Six hallmarks of cancerHanahan D., Weinberg R. Cell (2011)Friday, March 9, 12
  • 22. Current cancer therapeutics are limited Chemotherapy Antibodies Surgeryen.wikipedia.org/wiki/Doxorubicinwww.rikenresearch.riken.jpFriday, March 9, 12
  • 23. Controlled drug release reduces nonspecific effectsLow K.H. et al. Rapid Prototyping Journal (2007)Friday, March 9, 12
  • 24. Biomolecular targeting for cancer therapeuticswww.medscape.com/viewarticle/723827_4Friday, March 9, 12
  • 25. Enhanced permeability and retention (EPR) effect Macromolecules and particles between 60-400 nm accumulate in tumorswww.nature.com/nrd/journal/v2/n5/images/nrd1088-f3.gifD. P. O’Neal et al. Cancer Letters (2004)Friday, March 9, 12
  • 26. The future of biomaterials 1. Stem cells 2. Complex organs 3. siRNA / geneticsFriday, March 9, 12
  • 27. Biomaterials is a highly multidisciplinary field Physics Materials science Cell biology Medicine BiochemistryFriday, March 9, 12
  • 28. More (free) resources PLoS TED talks iTunes U @erikreinertsenFriday, March 9, 12
  • 29. Acknowledgements Benjamin Wu, DDS, PhD Bill Tawil, PhD Daniel Kamei, PhD Amy Chung, PhD Min Lee, PhD Jun KimFriday, March 9, 12