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Bioengineering Approaches for Regenerating Organs and Fighting Cancer

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I will present a basic overview of biomaterials for 1) tissue engineering and 2) cancer therapeutics.

I will present a basic overview of biomaterials for 1) tissue engineering and 2) cancer therapeutics.

Published in Technology , Business
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  • 1. Bioengineering Approaches for Regenerating Organs and Fighting Cancer Erik Reinertsen UCLA BioengineeringFriday, March 9, 12
  • 2. Three topics 1. The father of biomaterials 2. Tissue engineering 3. Cancer therapeuticsFriday, March 9, 12
  • 3. Robert Langerwww.cornell.eduFriday, March 9, 12
  • 4. GliadelFriday, March 9, 12
  • 5. Three topics 1. The father of biomaterials 2. Tissue engineering 3. Cancer therapeuticsFriday, March 9, 12
  • 6. Engineering tissues & organsFriday, March 9, 12
  • 7. Engineering tissues & organsLanger R, Vacanti K. Science (1993)Friday, March 9, 12
  • 8. Tissue engineering could address organ shortageswww.mdconsult.comFriday, March 9, 12
  • 9. In vivo-like platforms for pharmaceutical testingFriday, March 9, 12
  • 10. Huge potential in tissue engineering + stem cellswww.mdconsult.comFriday, March 9, 12
  • 11. Stem cell therapies could help millions of patients Cardiovascular diseases Autoimmune diseases Diabetes Osteoporosis Cancer Alzheimers disease Parkinsons disease Other 0 20 40 60 Millions of peoplePerry D. Science (2000)Friday, March 9, 12
  • 12. Scaffolds engineered from biocompatible polymers PLGA1 PCL2 Collagen31. www.techno-isel.com2. Wu Lab, UCLA Department of Bioengineering3. www.pharmainfo.netFriday, March 9, 12
  • 13. Biochemical signalsLutolf M., Hubbell J. Nature Biotechnology (2005)Friday, March 9, 12
  • 14. Physical signals MSC morphology changes with elasticityEngler A. Cell (2006)Friday, March 9, 12
  • 15. Fibroblasts spread more in lower fibrin concentration 5 mg/mL 10 mg/mL 20 mg/mL Day 1 500 um 500 um 1 mm Day 4 500 um 500 um 500 um Day 7 500 um 500 um 500 umReinertsen E., Tawil B., Wu B.M. Tissue Engineering (submitted)Friday, March 9, 12
  • 16. Cell viability is limited by oxygen transportDemol et al. Biomaterials (2010)Friday, March 9, 12
  • 17. 3D printing offers novel methods of shape controlFriday, March 9, 12
  • 18. Three topics 1. The father of biomaterials 2. Tissue engineering 3. Cancer therapeuticsFriday, March 9, 12
  • 19. Cancer is the #1 killer in the worldwww.tgrbio.comFriday, March 9, 12
  • 20. Cancer is the #1 killer in the world Worldwide -7.6 million deaths In the US alone -1.5 million cases -600,000 deathswww.who.int/mediawww.cdc.gov/nchs/fastats/lcod.htmFriday, March 9, 12
  • 21. Six hallmarks of cancerHanahan D., Weinberg R. Cell (2011)Friday, March 9, 12
  • 22. Current cancer therapeutics are limited Chemotherapy Antibodies Surgeryen.wikipedia.org/wiki/Doxorubicinwww.rikenresearch.riken.jpFriday, March 9, 12
  • 23. Controlled drug release reduces nonspecific effectsLow K.H. et al. Rapid Prototyping Journal (2007)Friday, March 9, 12
  • 24. Biomolecular targeting for cancer therapeuticswww.medscape.com/viewarticle/723827_4Friday, March 9, 12
  • 25. Enhanced permeability and retention (EPR) effect Macromolecules and particles between 60-400 nm accumulate in tumorswww.nature.com/nrd/journal/v2/n5/images/nrd1088-f3.gifD. P. O’Neal et al. Cancer Letters (2004)Friday, March 9, 12
  • 26. The future of biomaterials 1. Stem cells 2. Complex organs 3. siRNA / geneticsFriday, March 9, 12
  • 27. Biomaterials is a highly multidisciplinary field Physics Materials science Cell biology Medicine BiochemistryFriday, March 9, 12
  • 28. More (free) resources PLoS TED talks iTunes U @erikreinertsenFriday, March 9, 12
  • 29. Acknowledgements Benjamin Wu, DDS, PhD Bill Tawil, PhD Daniel Kamei, PhD Amy Chung, PhD Min Lee, PhD Jun KimFriday, March 9, 12