中興胚胎學

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中興胚胎學

  1. 1. The developing human 陳建榮 http://web.nchu.edu.tw/pweb/users/chenjr/
  2. 2. 教科書及參考資料:1. The Developing Human (7TH, 2003, by Keith L. Moore & T. V. N. Persaud)2. Langman’s medical embryology (9th, 2004, by T.W. Sadler)3. http://embryology.med.unsw.edu.au/4. 講義評量方式: 期中考 (45%) 期末考 (45%) 平時成積 (10%)
  3. 3. Embryology Human development is a continuous process that begins when a zygote is formed Development does not stop at birth
  4. 4. Developmental Periods Gametogenesis Gametogenesis  Spermatogenesis  Oogenesis Prenatal period (Fertilization)  Embryo: Zygote  Cleavage  Implantation  Gastrulation  Organogenesis  Fetus Postnatal period  Neonate (<1 month)  Infancy (< 1 yr)  Childhood  Puberty (13 yr – 16 yr)  Adulthood
  5. 5. 胎齡 : embryo fetusLNMP (last normal menstrual period) Trimester
  6. 6. 測量胚胎大小 :最大長頂臀長頂踵長
  7. 7. Carnegie stages are a system used by embryologists todescribe the apparent maturity of embryos 1st trimester
  8. 8. 1st week
  9. 9. Formation of Bilaminar Embryonic DiscStage 5: 7th –12th day full implantation 2nd week
  10. 10. Stages 6-9: Day 13-21 Somites 3rd week
  11. 11. Stages 10-17 4th to 6th week
  12. 12. 78  Embryo (end of the 8th week) - all major structures are present  Fetus (after 8th week)
  13. 13. Data For Carnegie Stages Comparison Graph(Species/Days)Species Stage 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23Human Days 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58Baboon Days 23 25 27 28 29 30 31 33 35 37 39 41 43 45 47Rhesus Days 21 22 25 28 29 30 32 34 36 37 38 40 42 44 46MonkeyMarmoset Days 57   60   64   67       74         9. 15.Mouse Days 9 10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 16 5 5 10.Rat Days 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5 5Chinese 10 16. Days 10 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 17Hamster .5 5 14.Guinea Pig Days 15 15.5 17 18 19 20 21 22 23 24 25 26 27 29 5 8.Rabbit Days 8 9.5 10.5 11 12 12.5 13.5 14 14.5 15.5 16 16.5 17 18 5Sheep Days 15 16 17.5 18.5 19.5 20.5 22 23 24.5 25.5 27.5 29.5 30 33   30.Pig Days 14 15 16 17 18 19 20.5 21.5 23 24 25.5 27.5 29 32.5 5 1.Chicken Days 1 2 2.25 2.5 3 3.25 3.75 4.75 5.5 6.25 7.25 7.75 8.5 10 5
  14. 14. Genetics and Molecular biology are applied in human development Ian Wilmut [1997] Somatic cell nuclear transfer – Dolly lamb Embryonic stem cell
  15. 15. Somatic cell nuclear transfer
  16. 16. Embryonic stem cell Morula BlastocytStem cell
  17. 17. Anatomical position

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