RNA Structure

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  • 1. Alan Sotelo Alberto QuiñonezGalo Garcia de Leon Ivan Flores Roman
  • 2.  The major role of RNA is to participate in protein synthesis, which requires three classes of RNA: Messenger RNA (mRNA) Transfer RNA (tRNA) Ribosomal RNA (rRNA).
  • 3.  mRNA is transcribed from DNA, carrying information for protein synthesis. the mRNA carries the genetic information from the nucleus to the site of protein synthesis (ribosome) in the cytoplasm to be translated.
  • 4.  Short-chain RNA molecules present in the cell that attach the correct amino acid to the protein chain that is being synthesized at the ribosome of the cell. The major role of tRNA is to translate mRNA sequence into amino acid sequence. Consists of 70 to 80 nucleotides.
  • 5.  rRNA molecules are produced in the nucleus, they are transported to the cytoplasm, where they combine with tens of specific proteins to form a ribosome.
  • 6.  Ribozymes are the RNA molecules with catalytic activity. They were discovered in early 1980s by Thomas Cech and Sidney Altman who shared the 1989 Nobel Prize in Chemistry.
  • 7.  Major types of small RNA molecules: Small nuclear RNA (snRNA) - involved in mRNA splicing. Small nucleolar RNA (snoRNA) - directs the modification of ribosomal RNAs. Micro RNA (miRNA) and short interfering RNA (siRNA) - regulate gene expression.
  • 8.  Nucleic acids were discovered in 1868 by Friedrich Miescher, who called the material nuclein since it was found in the nucleus. It was later discovered that prokaryotic cells, which do not have a nucleus, also contain nucleic acids.
  • 9.  The role of RNA in protein synthesis was suspected already in 1939. Severo Ochoa won the 1959 Nobel Prize in Medicine after he discovered how RNA is synthesized.
  • 10.  The sequence of the 77 nucleotides of a yeast tRNA was found by Robert W. Holley in 1965, winning Holley the 1968 Nobel Prize in Medicine.
  • 11.  In 1967, Carl Woese realized RNA can be catalytic and proposed that the earliest forms of life relied on RNA both to carry genetic information and to catalyze biochemical reactions
  • 12.  http://www.biology- online.org/dictionary/Transfer_rna http://www.web- books.com/MoBio/Free/Ch3C6.htm http://www.news-medical.net/health/RNA- Discovery.aspx