TECHNICAL INSIGHTS           ALERT
Industrial Bioprocessing AlertCONTROLLING MOSQUITOES WITH YEAST-BASED LARVICIDE          Mosquitoes have long been a bane ...
Industrial Bioprocessing Alert          According to EntoGeneX founder and director of technology and innovationAlan Brand...
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Controlling mosquitoes with_yeast-based_larvicide

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Controlling mosquitoes with_yeast-based_larvicide

  1. 1. TECHNICAL INSIGHTS ALERT
  2. 2. Industrial Bioprocessing AlertCONTROLLING MOSQUITOES WITH YEAST-BASED LARVICIDE Mosquitoes have long been a bane to mankind. Infamous as an irritatingpest that causes itchy bites, mosquitoes are the main culprits for the spread ofdeadly diseases such as dengue, malaria, chikungunya and Japanese encephalitis.Mosquito-transmitted diseases are responsible for millions of deaths worldwide,and in some cases capable of causing widespread outbreaks. Rather than risking a disease epidemic, governments, health organizationsand consumers alike have lauded campaigns to control mosquito vectorpopulations to nip the problem in the bud. Consequently, Malaysian companyEntoGeneX Industries has proposed a natural biocontrol solution for eradicatingmosquitoes in our communities. EntoGeneX has launched MOUSTIcide, a trypsin-modulating oostatic factor(TMOF)-based mosquito larvicide, as well as Moustique, which uses the EGX-101biorepellent. TMOF is an active peptide expressed by the nonpathogenic yeastPichia pastoris, which kills mosquito larvae when ingested. MOUSTIcide applied tomosquito breeding sites has proven to be an environmentally friendly way tocontrol mosquito larvae populations in an aquatic environment, affordingprotection for up to 4 weeks. Conventional insecticides involve the use of airborne neurotoxic chemicalssprayed in areas where adult mosquitoes are found. This raises problems such asmosquitoes developing insecticide resistance, the need for frequent reapplication,accidental killing of other insect species and negative environmental impacts.TMOF is a natural larvicide, which is toxic only to mosquitoes and closely-relatedinsect species, ensuring a targeted solution of eliminating mosquito larvaepopulations. In comparison, spraying kills the adult mosquito, but does noteradicate the next generation of larvae, which is lurking in nearby stagnant watersupplies. EGX-101 (found in nature in wild tomatoes), is an all-natural pestrepellent, which is applied to lotions and insect sprays for the prevention ofmosquito bites for up to 8 hours after application. It is a greener alternative toDEET (N,N-Diethyl-meta-toluamide), the current standard active ingredient inconventional insect repellents, which is perceived to be corrosive, odiferous, andmay cause toxic effects. Use of this information is determined by license agreement; any unauthorized use is prohibited. © 2010, Frost & Sullivan
  3. 3. Industrial Bioprocessing Alert According to EntoGeneX founder and director of technology and innovationAlan Brandt, both MOUSTIcide and Moustique products are highly effective toolsfor vector control professionals and the general public. "Both products areextremely safe with no toxic properties towards nontarget species, includinghumans. Initial field evaluations of the products have shown that they areextremely effective in reducing the incidence of dengue in areas where they areutilized," he says. In Malaysia where dengue outbreaks frequently occur, the Ministry ofHealth is already using MOUSTIcide to control mosquito populations. Moustiqueinsect repellent is already available in selected commercial retailers throughoutthe country. The company expects that its products will replace conventional mosquitocontrol insecticides due to their environmentally friendly, safe, nontoxic nature,as well as their specificity to mosquitoes and lack of resistance problems. Brandtstrongly believes in the uniqueness of EntoGeneX’s technology commenting,"There are no products available anywhere in the world having these highlydesirable characteristics." The company is in an exclusive license agreement with the University ofFlorida, which holds 16 patents for TMOF technology while EGX-101 patentapplications are underway. In addition, TMOF has already been registered withthe US Environmental Protection Agency. The company already operates a pilotplant in Malaysia, and is keen to expand its horizons to India, Sri Lanka, andAfrica. This technology has been commercialized since 2009. It will haveapplications in the biocontrol and pest control industries. Details: Dr. Alan E. Brandt, Founder and Director of Technology &Innovation, EntoGeneX Industries Sdn Bhd, Suite 16-04 & 17-04, Level 16 & 17,GTower, 199 Jalan Tun Razak, 50400 Kuala Lumpur, Malaysia. Phone: +603-2095-7188. Fax: +603-2095-7122. E-mail: aeb.entogenex@gmail.com. URL:www.entogenex.com. Use of this information is determined by license agreement; any unauthorized use is prohibited. © 2010, Frost & Sullivan

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