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Carcinoid Tumour Biochemical and Radiological Testing Gillian Harris  4 th  year MBBS
Carcinoid Tumour-background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Biochemical Markers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
5-hydroxy-indole-acetic acid  (5-HIAA) ,[object Object],[object Object],[object Object],[object Object]
Serotonin overproduction ,[object Object],[object Object],[object Object],[object Object]
Other methods for measuring serotonin overproduction ,[object Object],[object Object]
 
Chromogranin A (CgA) ,[object Object],[object Object],[object Object]
 
 
[object Object],[object Object],[object Object],[object Object]
Other causes of increased serum CgA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnostic Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
111 In-Pentetreotide Scintigraphy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
Meta-iodobenzylguanidine (MIBG) Scintigraphy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Conventional Imaging Modalities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Octreotide scintigraphy-highest sensitivity MIBG-when negative scan Endoscopic ultrasound-90% accuracy for localisation and staging of colorectal carcinoids MRI Hindgut Octreotide Scintigraphy-staging and identification of primary lesion. 83% diagnostic accuracy, 100% PPV Transabdominal Ultrasound-1/3 Small bowel carcinoids, 2/3 liver metastases CT/MRI-to monitor responsiveness to treatment, only detect 50% primary tumours Double contrast barium studies-to assess for imminent obstruction Midgut Chest radiography-occasionally detects lesions CT/MRI-identification of primary tumour, lymph nodes, facilitates biopsy diagnosis Octreotide Scintigraphy-negative in 30% but most specific Foregut Imaging (12) Tumour type
Positron Emission Tomography (PET) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Biochemical and Imaging Tests for Carcinoid Tumours

  • 1. Carcinoid Tumour Biochemical and Radiological Testing Gillian Harris 4 th year MBBS
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  • 18. Octreotide scintigraphy-highest sensitivity MIBG-when negative scan Endoscopic ultrasound-90% accuracy for localisation and staging of colorectal carcinoids MRI Hindgut Octreotide Scintigraphy-staging and identification of primary lesion. 83% diagnostic accuracy, 100% PPV Transabdominal Ultrasound-1/3 Small bowel carcinoids, 2/3 liver metastases CT/MRI-to monitor responsiveness to treatment, only detect 50% primary tumours Double contrast barium studies-to assess for imminent obstruction Midgut Chest radiography-occasionally detects lesions CT/MRI-identification of primary tumour, lymph nodes, facilitates biopsy diagnosis Octreotide Scintigraphy-negative in 30% but most specific Foregut Imaging (12) Tumour type
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