Dissociation of neural networks for anticipation and consumption

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Dissociation of neural networks for anticipation and consumption

  1. 1. L.Rademacher et al., 2010 Neuroimage Dissociation of neural networks for anticipation and consumption of monetary and social reward Anna Jo May 4th, 2010
  2. 2. Introduction Reward Anticipation Reward Processing Reward Consumption Money Social Approval Ventral Striatum(NAcc): Reward-related Brain area “the universal mediator of reward prediction” Aim: To provide evidence for dissociable neural networks involved in reward anticipation and reward consumption
  3. 3. Experimental Procedure Stimuli and task Image analysis 1. Participants: 32 subjects (13 men) 2. 88 trials/task X 2(MID, SID) = 176 trials MID SID No Outcome No Outcome Happy closed 0.2 Euros mouth Happy open 1.0 Euros mouth Happy open 3.0 Euros mouth exuberant “Monetary Incentive “Social Incentive Delay”(MID) task Delay”(SID) task Knutson et al.(2000) Spreckelmeyer et al.(2000)
  4. 4. Experimental Procedure Stimuli and task Image analysis Anticipation vs. Consumption Contrasts MID Anticipation Anticipated Anticipated phase “hit outcome” “no outcome” Contrast-specific ROI Consumption Gained Gained phase “hit outcome” “no outcome” SID Signal Change 1 Anticipation hit outcome > Anticipation no outcome 2 Consumption hit outcome > Consumption no outcome 2 tasks(MID, SID) 3 Anticipation hit outcome > Consumption hit outcome X 4 reward levels 4 Consumption hit outcome > Anticipation hit outcome (no potential outcome, Low, Medium, High) 5 Consumption MID hit outcome > Consumption SID hit outcome X 22 trials 5 Consumption SID hit outcome > Consumption MID hit outcome
  5. 5. Results Behavioral Results Neuroimaging Results Reaction times “tasks”(monetary, social) and “incentive magnitude”(no outcome, low, medium, high) 1 MID [219 ms(SE=5.98)] vs. SID [232 ms(SE=5.38)] Linearly decreased with increasing levels of potential 2 reward in both tasks (F(3,25)=6.29, p=0.002) Significantly faster reaction times for all levels of 3 reward compared to ‘no outcome’ condition Faster reaction times to the highest level of potential 4 reward compared to the lowest level of potential Circles with one, two, and three bars announce reward (all p<0.05) increasing levels of potential reward, triangles represent “no outcome.” Error bars indicate the “task” and “incentive magnitude” did not interact standard error of the mean (s.e.m.). 5 (p>0.05)
  6. 6. Results Behavioral Results Neuroimaging Results Reward Anticipation 1 Anticipation hit outcome > Anticipation no outcome => bilateral activation of the putamen, caudatus and NACC 3 Anticipation hit outcome > Consumption hit outcome => Ventral Striatum for both tasks - Activation foci during MID (left) and SID (right) “hit outcome” anticipation compared to “no outcome” anticipation masked by the respective contrast (“hit outcome”anticipation > ”hit outcome” consumption) (p < 0.001, uncorrected; y=9). - A conjunction analysis between the two tasks (MID, SID) was performed and the resulted peak activation appearing in the left ventral striatum (NAcc)
  7. 7. Results Behavioral Results Neuroimaging Results Reward Consumption 5 Consumption MID hit outcome > Consumption SID hit outcome => Thalamus activation for monetary reward consumption 4 Consumption hit outcome > Anticipation hit outcome => Thalamus activation for MID task => A linear increase of activations with higher levels of reward Activation focus during MID consumption compared to independent of incentive type “no outcome” masked by the contrast (MID “hit outcome” consumption > MID “hit outcome” anticipation) (p<0.001) 5 Consumption SID hit outcome > Consumption MID hit outcome => Bilateral Amygdala activation for social reward consumption 4 Consumption hit outcome > Anticipation hit outcome => Amygdala recruitment for SID task => A significant main effect of incentive magnitude in response Activation foci during SID consumption compared to “no to reward compared to “no outcome”, independent of incentive outcome” masked by the contrast (SID “hit outcome” type consumption > SID “hit outcome” anticipation) (p<0.001)
  8. 8. Discussion Interpretation Summary 1. Ventral striatal structures were not found activated during the consumption phase 2. Prefrontal activation is specifically related to monitoring of unwanted outcomes (Dillon et al., 2008). 3. The thalamic activation observed in current experiment may reflect a reward value prediction process. => The thalamus: an important function in goal-directed behaviour through ranking of incentive value. 4. While the amygdala was strongly activated in response to socially rewarding pictures, the activation evoked by monetary stimuli was much weaker. => amygdala is also associated with the processing of facial expressions Presentation of Monetary Rewards Social Stimuli Thalamus Amygdalae activation

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