main topics 1 – noninvasive telemetry 2 – implantable telemetry 3 – innovative software solutions 4 – observational data p...
primates primates are intelligent, social animals with a complex range of both physical and emotional needs insuring the c...
primates emka  TECHNOLOGIES  provides a complete array of products uniquely suited for the acquisition and analysis of phy...
1 – noninvasive telemetry acquire robust physiological data on freely moving animals without restraint  <ul><ul><ul><li>re...
1 – noninvasive telemetry no surgery is required <ul><ul><ul><li>pre-surgical screening of animals to be implanted with de...
1 – noninvasive telemetry real time transmission of multi-lead ecg, temperature, and activity, with optional blood pressur...
1 – noninvasive telemetry devices transmit on unique frequencies with no crosstalk  <ul><ul><ul><li>simultaneous transmiss...
1 – noninvasive telemetry emka PACK  transmitter <ul><ul><ul><li>transmitter in animal jacket  dimensions 117 mm x 78 mm x...
1 – noninvasive telemetry custom-designed and field tested jacket systems specifically for primates <ul><ul><ul><li>comfor...
1 – noninvasive telemetry compatibility with emka  TECHNOLOGIES  innovative software system  <ul><ul><ul><li>iox 2   </li>...
1 – noninvasive telemetry frequently asked questions <ul><ul><ul><li>do electrodes come off? yes they do… 3 to 5% of the t...
1 – noninvasive telemetry why use emka PACK?   <ul><ul><ul><li>no surgery required </li></ul></ul></ul><ul><ul><ul><li>cho...
2 – implantable telemetry measurement of blood pressure and a variety  of biopotential signals  <ul><ul><ul><li>ecg, eeg, ...
2 – implantable telemetry no loss of valuable animals to device battery depletion  <ul><ul><ul><li>Telemetry Research impl...
2 – implantable telemetry transmission <ul><ul><ul><li>devices transmit on unique frequencies with no crosstalk  </li></ul...
2 – implantable telemetry SNA receiver output of integrated  signal  <ul><ul><ul><li>with adjustable time-constant  </li><...
2 – implantable telemetry compatibility with emka  TECHNOLOGIES  innovative software system  <ul><ul><ul><li>iox 2   </li>...
3 – innovative software solutions shape recognition technology <ul><ul><ul><li>primate electrocardiogram analysis is diffi...
3 – innovative software solutions concurrent analysis of hemodynamic, respiratory and other waveform data,  including eeg ...
3 – innovative software solutions ventricular repolarization  measurements  <ul><ul><ul><li>QT interval assessments with  ...
3 – innovative software solutions shape-based identification of arrhythmias  <ul><ul><ul><li>facilitating ecg analysis in ...
3 – innovative software solutions HRV analysis  <ul><ul><ul><li>including histograms,  time-domain parameters,  fast fouri...
4 – observational data clinical and behavioral observations  without investigator interaction  <ul><ul><ul><li>visual cont...
4 – observational data secured synchronized video data  <ul><ul><ul><li>embedded in our software platform </li></ul></ul><...
4 – observational data ideal for screening animals for health  and behavioral suitability  <ul><ul><ul><li>before study as...
summary measure blood pressure and biopotentials without crosstalk or battery depletion acquire robust physiological data ...
website visit our websites for complete product descriptions, case studies, a knowledge base,  & frequently asked  questio...
documentation visit our website for application specific leaflets or product sheets, downloads  & much more! www.emka.fr a...
literature you can consult  publications  referring to  emka   TECHNOLOGIES   on our website http://www.emka.fr/literature...
references major industry labs & CROs  use  emka  TECHNOLOGIES ’ solutions for primates on a daily basis!
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emka TECHNOLOGIES - solutions for primates

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primates are intelligent, social animals with a complex range of both physical and emotional needs

insuring the comfort and welfare of primates while maximizing experimental data integrity provides a unique challenge

emka TECHNOLOGIES provides a complete array of products uniquely suited for the acquisition and analysis of physiological data from nonhuman primates

http://www.emka.fr
http://telemetry.emka.fr

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  • Restraint for data acquisition can be a highly stressful procedure for nonhuman primates. In addition, stress results in a number of physiological responses that may increase unwanted data variability. The noninvasive telemetry system developed by emka TECHNOLOGIES allows scientists to acquire robust physiological data on freely moving animals in their home environment, improving animal welfare, as well as improving the scientific integrity of the results.
  • Fully implantable systems also offer advantages for nonhuman primate research. Following surgery and recovery, data can be acquired in an unrestrained animal for long periods of time. However, implantable telemetry systems have limitations. Many implantable devices transmit on the same frequency, necessitating stress-inducing single housing for simultaneous acquisition. Battery depletion is a significant problem for totally implantable telemetry devices, as in vivo replacement is generally impossible, and failure of the device may mean the waste of an experimental animal’s life before any research objectives have been achieved. In response, emka TECHNOLOGIES now offers innovative implantable telemetry from Telemetry Research.
  • QT-prolongation-in-the-primate
  • QT-prolongation-in-the-primate
  • emka TECHNOLOGIES - solutions for primates

    1. 2. main topics 1 – noninvasive telemetry 2 – implantable telemetry 3 – innovative software solutions 4 – observational data primates
    2. 3. primates primates are intelligent, social animals with a complex range of both physical and emotional needs insuring the comfort and welfare of primates while maximizing experimental data integrity provides a unique challenge
    3. 4. primates emka TECHNOLOGIES provides a complete array of products uniquely suited for the acquisition and analysis of physiological data from nonhuman primates
    4. 5. 1 – noninvasive telemetry acquire robust physiological data on freely moving animals without restraint <ul><ul><ul><li>restraint for data acquisition can be a highly stressful procedure for nonhuman primates </li></ul></ul></ul><ul><ul><ul><li>stress results in a number of physiological responses that may increase unwanted data variability </li></ul></ul></ul><ul><ul><ul><li>acquire robust physiological data on freely moving animals in their home environment </li></ul></ul></ul><ul><ul><ul><li>improve animal welfare </li></ul></ul></ul><ul><ul><ul><li>improve the scientific integrity of the results </li></ul></ul></ul>
    5. 6. 1 – noninvasive telemetry no surgery is required <ul><ul><ul><li>pre-surgical screening of animals to be implanted with devices </li></ul></ul></ul><ul><ul><ul><li>toxicology applications </li></ul></ul></ul><ul><ul><ul><li>intermittent data acquisitions in chronic studies </li></ul></ul></ul><ul><ul><ul><li>biologics applications </li></ul></ul></ul><ul><ul><ul><li>USA </li></ul></ul></ul><ul><ul><ul><li>EUROPE </li></ul></ul></ul>noninvasive telemetry is ideal for:
    6. 7. 1 – noninvasive telemetry real time transmission of multi-lead ecg, temperature, and activity, with optional blood pressure via an arterial VAP and respiratory parameters via RIP belts
    7. 8. 1 – noninvasive telemetry devices transmit on unique frequencies with no crosstalk <ul><ul><ul><li>simultaneous transmission in pair or group housing situations possible </li></ul></ul></ul><ul><ul><ul><li>each receiver and transmitter pair operates on a specific frequency </li></ul></ul></ul><ul><ul><ul><li>data is transmitted digitally as a succession of packets </li></ul></ul></ul><ul><ul><ul><li>each data packet contains an identification code, unique to each transmitter and its associated receiver </li></ul></ul></ul>
    8. 9. 1 – noninvasive telemetry emka PACK transmitter <ul><ul><ul><li>transmitter in animal jacket dimensions 117 mm x 78 mm x 27 mm </li></ul></ul></ul><ul><ul><ul><li>weight with AAR6 batteries:180g </li></ul></ul></ul><ul><ul><ul><li>transmission range adjustable from 10 to 100 m </li></ul></ul></ul><ul><ul><ul><li>sampling frequency: 500Hz </li></ul></ul></ul><ul><ul><ul><li>continuous transmission on same batteries: 48 to 96 hours, 24hr with respiration </li></ul></ul></ul>
    9. 10. 1 – noninvasive telemetry custom-designed and field tested jacket systems specifically for primates <ul><ul><ul><li>comfortable enough to be well tolerated yet sturdy enough to allow pair or group housing </li></ul></ul></ul>
    10. 11. 1 – noninvasive telemetry compatibility with emka TECHNOLOGIES innovative software system <ul><ul><ul><li>iox 2 </li></ul></ul></ul><ul><ul><ul><li>ecg AUTO </li></ul></ul></ul><ul><ul><ul><li>third party software package </li></ul></ul></ul>
    11. 12. 1 – noninvasive telemetry frequently asked questions <ul><ul><ul><li>do electrodes come off? yes they do… 3 to 5% of the time always in the first 15mn early enough to allow for repositioning and avoid any loss of valuable data </li></ul></ul></ul><ul><ul><ul><li>is signal quality always perfect? no it is not very good quality 80% of the time (enough for PR) good quality (enough for QT) 95% of time </li></ul></ul></ul>
    12. 13. 1 – noninvasive telemetry why use emka PACK? <ul><ul><ul><li>no surgery required </li></ul></ul></ul><ul><ul><ul><li>choice of physiological data </li></ul></ul></ul><ul><ul><ul><li>single or group housing </li></ul></ul></ul><ul><ul><ul><li>up to 100 meter transmission range </li></ul></ul></ul><ul><ul><ul><li>negligible recurring costs </li></ul></ul></ul><ul><ul><ul><li>validated by major industry labs & CROs </li></ul></ul></ul><ul><ul><ul><li>validated and GLP compliant </li></ul></ul></ul><ul><ul><ul><li>highly secured data transmission </li></ul></ul></ul><ul><ul><ul><li>open system </li></ul></ul></ul><ul><ul><ul><li>available from a fast moving, innovative supplier! </li></ul></ul></ul>
    13. 14. 2 – implantable telemetry measurement of blood pressure and a variety of biopotential signals <ul><ul><ul><li>ecg, eeg, and emg </li></ul></ul></ul><ul><ul><ul><li>the only commercially available implantable telemetry device capable of measuring high fidelity sympathetic nerve activity (sna) in freely moving animals </li></ul></ul></ul>
    14. 15. 2 – implantable telemetry no loss of valuable animals to device battery depletion <ul><ul><ul><li>Telemetry Research implants are recharged by patented inductive energy transfer, which allows the devices to recharge while in the animal </li></ul></ul></ul>
    15. 16. 2 – implantable telemetry transmission <ul><ul><ul><li>devices transmit on unique frequencies with no crosstalk </li></ul></ul></ul><ul><ul><ul><li>simultaneous transmission in pair or group housing situations possible </li></ul></ul></ul><ul><ul><ul><li>transmission range of up to 5 m / 16 feet </li></ul></ul></ul><ul><ul><ul><li>no need for restrictive caging or additional signal boosting devices that are subject to animal damage </li></ul></ul></ul>
    16. 17. 2 – implantable telemetry SNA receiver output of integrated signal <ul><ul><ul><li>with adjustable time-constant </li></ul></ul></ul>
    17. 18. 2 – implantable telemetry compatibility with emka TECHNOLOGIES innovative software system <ul><ul><ul><li>iox 2 </li></ul></ul></ul><ul><ul><ul><li>ecg AUTO </li></ul></ul></ul><ul><ul><ul><li>third party software package </li></ul></ul></ul>
    18. 19. 3 – innovative software solutions shape recognition technology <ul><ul><ul><li>primate electrocardiogram analysis is difficult, as it often contains low amplitude waveforms, and frequent morphology changes </li></ul></ul></ul><ul><ul><ul><li>industry-leading waveform analysis program, ecg AUTO , is uniquely suited to the challenges of the primate ecg </li></ul></ul></ul><ul><ul><ul><li>shape recognition analysis allows scientist to “educate” program as analysis progresses </li></ul></ul></ul>
    19. 20. 3 – innovative software solutions concurrent analysis of hemodynamic, respiratory and other waveform data, including eeg and sleep scoring capabilities
    20. 21. 3 – innovative software solutions ventricular repolarization measurements <ul><ul><ul><li>QT interval assessments with traditional and individual correction formulae </li></ul></ul></ul><ul><ul><ul><li>restitution with TQ measurements, and Tarea, Tpeak-end </li></ul></ul></ul><ul><ul><ul><li>other user-defined custom repolarization parameters </li></ul></ul></ul><ul><ul><ul><li>QT prolongation </li></ul></ul></ul>
    21. 22. 3 – innovative software solutions shape-based identification of arrhythmias <ul><ul><ul><li>facilitating ecg analysis in cases of marked morphology or rhythm disturbance </li></ul></ul></ul>
    22. 23. 3 – innovative software solutions HRV analysis <ul><ul><ul><li>including histograms, time-domain parameters, fast fourier transforms, and Poincaré plots </li></ul></ul></ul>
    23. 24. 4 – observational data clinical and behavioral observations without investigator interaction <ul><ul><ul><li>visual contact with primates can stress the animals and affect their behavior, making valid clinical observations challenging </li></ul></ul></ul><ul><ul><ul><li>paired or group housing can make the measurement of individual food and water consumption, and clinical signs such as vomiting difficult to assign to individual animals </li></ul></ul></ul><ul><ul><ul><li>primates in biological safety level category 3 and 4 facilities need observations without investigator contact </li></ul></ul></ul>
    24. 25. 4 – observational data secured synchronized video data <ul><ul><ul><li>embedded in our software platform </li></ul></ul></ul><ul><ul><ul><li>robust and meaningful observations without the confounding effects of investigator contact </li></ul></ul></ul><ul><ul><ul><li>link video data with other physiological signals, allowing an investigator to assess the behavior occurring during a particular change in ecg, eeg or respiratory parameter </li></ul></ul></ul><ul><ul><ul><li>adjustable image resolution to limit file size </li></ul></ul></ul><ul><ul><ul><li>infrared recording, making dark cycle observation possible </li></ul></ul></ul>
    25. 26. 4 – observational data ideal for screening animals for health and behavioral suitability <ul><ul><ul><li>before study assignment </li></ul></ul></ul><ul><ul><ul><li>before surgery </li></ul></ul></ul>
    26. 27. summary measure blood pressure and biopotentials without crosstalk or battery depletion acquire robust physiological data on freely moving animals without restraint or surgery accurate, efficient analysis of ecg, hemodynamic, respiratory and other waveform data clinical and behavioral observations without investigator interaction 1 – noninvasive telemetry 2 – implantable telemetry 3 – innovative software 4 – observational data
    27. 28. website visit our websites for complete product descriptions, case studies, a knowledge base, & frequently asked questions: www.emka.fr and telemetry.emka.fr
    28. 29. documentation visit our website for application specific leaflets or product sheets, downloads & much more! www.emka.fr and telemetry.emka.fr
    29. 30. literature you can consult publications referring to emka   TECHNOLOGIES on our website http://www.emka.fr/literature-52.html
    30. 31. references major industry labs & CROs use emka TECHNOLOGIES ’ solutions for primates on a daily basis!

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