nuclear envelope

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nuclear envelope

  1. 1. Nuclear receptors Emilie Lilford Group 11
  2. 2. Biochemical definition of a receptor
  3. 3. Chemical change  physiological change  biological function LigandReceptor
  4. 4. Types of receptors and locations:• Cell surface receptors• Receptors located in the cytoplasm• Nuclear receptors
  5. 5. Ligands of nuclear receptors
  6. 6. Structures of some nuclear receptor ligands and their corresponding receptors name.
  7. 7. Structural organization
  8. 8. Sandwich filling model of ligand binding domain (LBD) LBD
  9. 9. DNA binding domain (DBD) – structure of the human progesterone receptor DBD
  10. 10. What is a Domain?• Independent subunits of proteins.• Between 25 -500 amino acids in length.• Independently stable and folded.• Can diverge and converge.• Domain represents function.
  11. 11. Domains of nuclear receptors• Zinc fingers• LBD• DBD• N-terminal + C-terminal
  12. 12. How nuclear receptors work.

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