The Cell Membrane FOS 3 Infectious Disease Unit
Composition of Cell Membrane <ul><li>Cell Membranes are NOT all identical, but have FOUR common parts: </li></ul><ul><ul><...
Lipid Foundation- Phospholipid Bilayer <ul><li>Consist of a: </li></ul><ul><ul><li>Glycerol backbone </li></ul></ul><ul><u...
Lipid Foundation- Phospholipids <ul><li>Fatty Acid side is NONPOLAR </li></ul><ul><ul><li>Nonsoluble in water </li></ul></...
Lipid Bilayer <ul><li>Creates barrier to water soluble molecules </li></ul><ul><li>Lipid bilayer is fluid, yet stable. </l...
Fluid Mosaic Model
History of the Fluid Mosaic Model <ul><li>If you want more information of this go to:http://www1.umn.edu/ships/9-2/membran...
Controls the fluidity of the Cell Membrane <ul><li>Temperature </li></ul><ul><li>Length of tails and kinks in tails </li><...
Cholesterol in Cell Membrane <ul><li>The phospholipid bilayer also contains cholesterol molecules. This gives the layer gr...
How do things get through if there is a barrier? <ul><li>Simple diffusion. </li></ul><ul><li>Through “kinks” in the fatty ...
Protein Functions in the Membrane <ul><li>Transmembrane  </li></ul><ul><li>ID Markers </li></ul><ul><li>Receptors </li></u...
Transmembrane Proteins extend across lipid bilayer <ul><li>These proteins can have both a polar and a nonpolar region. </l...
Proteins act as Cell Identification Markers <ul><li>Glycolipids and glycoproteins </li></ul><ul><li>Cell ID Markers </li><...
Major Histocompatibility Complex <ul><li>Unique to every individual </li></ul><ul><ul><li>Except identical twins </li></ul...
Cell Surface Receptors
Channel Proteins
Carrier Proteins <ul><li>They do not extend through the membrane </li></ul><ul><li>They bond and drag molecules through th...
Proteins used to attach Cytoskeleton <ul><li>Receptor proteins help to attach the cytoskeleton inside the cell. </li></ul>
Membrane Protein Functions Receptor
Membrane Protein Functions
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Cell membrane

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  • http://library.thinkquest.org/C004535/media/cell_membrane.gif
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  • http://scienceblogs.com/afarensis/upload/2006/03/lipidbilayer.gif What are some water soluble molecules?
  • http://www-3.unipv.it/webbio/anatcomp/freitas/2007-2008/cholesterol.jpg
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  • Cell membrane

    1. 1. The Cell Membrane FOS 3 Infectious Disease Unit
    2. 2. Composition of Cell Membrane <ul><li>Cell Membranes are NOT all identical, but have FOUR common parts: </li></ul><ul><ul><li>Lipid Bilayer </li></ul></ul><ul><ul><li>Transmembrane Protein </li></ul></ul><ul><ul><li>Network of supporting fibers </li></ul></ul><ul><ul><li>Glycoproteins </li></ul></ul>
    3. 3. Lipid Foundation- Phospholipid Bilayer <ul><li>Consist of a: </li></ul><ul><ul><li>Glycerol backbone </li></ul></ul><ul><ul><li>2 Fatty Acid tails (nonpolar/ </li></ul></ul><ul><ul><li>hydrophobic) </li></ul></ul><ul><ul><li>Phosphate Head (polar/hydrophilic) </li></ul></ul>
    4. 4. Lipid Foundation- Phospholipids <ul><li>Fatty Acid side is NONPOLAR </li></ul><ul><ul><li>Nonsoluble in water </li></ul></ul><ul><li>Phosphate side is POLAR </li></ul><ul><ul><li>Soluble in water </li></ul></ul>
    5. 5. Lipid Bilayer <ul><li>Creates barrier to water soluble molecules </li></ul><ul><li>Lipid bilayer is fluid, yet stable. </li></ul>
    6. 6. Fluid Mosaic Model
    7. 7. History of the Fluid Mosaic Model <ul><li>If you want more information of this go to:http://www1.umn.edu/ships/9-2/membrane.htm </li></ul>
    8. 8. Controls the fluidity of the Cell Membrane <ul><li>Temperature </li></ul><ul><li>Length of tails and kinks in tails </li></ul><ul><li>Cholesterol </li></ul>
    9. 9. Cholesterol in Cell Membrane <ul><li>The phospholipid bilayer also contains cholesterol molecules. This gives the layer greater strength, more flexibility, less fluid and less permeable to ions and monosaccharides. </li></ul>
    10. 10. How do things get through if there is a barrier? <ul><li>Simple diffusion. </li></ul><ul><li>Through “kinks” in the fatty acid tails </li></ul><ul><ul><li>Closely aligned tails have C-C (single bonds) </li></ul></ul><ul><ul><li>C=C (double/triple bonds) cause “kinks” </li></ul></ul>
    11. 11. Protein Functions in the Membrane <ul><li>Transmembrane </li></ul><ul><li>ID Markers </li></ul><ul><li>Receptors </li></ul><ul><li>Channels </li></ul><ul><li>Carrier </li></ul><ul><li>Cytoskeleton attachment and support </li></ul>
    12. 12. Transmembrane Proteins extend across lipid bilayer <ul><li>These proteins can have both a polar and a nonpolar region. </li></ul>
    13. 13. Proteins act as Cell Identification Markers <ul><li>Glycolipids and glycoproteins </li></ul><ul><li>Cell ID Markers </li></ul><ul><li>This is particularly important in the immune system </li></ul>
    14. 14. Major Histocompatibility Complex <ul><li>Unique to every individual </li></ul><ul><ul><li>Except identical twins </li></ul></ul><ul><li>Consists of proteins that attach to exterior cells and antigens </li></ul><ul><li>Allows T-Cells in the immune system to recognize and attack foreign cells </li></ul><ul><li>Glycolipids also differentiate between tissues of same individual </li></ul><ul><ul><li>A, B, AB and O blood group markers. </li></ul></ul>
    15. 15. Cell Surface Receptors
    16. 16. Channel Proteins
    17. 17. Carrier Proteins <ul><li>They do not extend through the membrane </li></ul><ul><li>They bond and drag molecules through the lipid bilayer and release them on the opposite side. </li></ul>
    18. 18. Proteins used to attach Cytoskeleton <ul><li>Receptor proteins help to attach the cytoskeleton inside the cell. </li></ul>
    19. 19. Membrane Protein Functions Receptor
    20. 20. Membrane Protein Functions
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