Cell membrane
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  • http://library.thinkquest.org/C004535/media/cell_membrane.gif
  • http://staff.jccc.net/pdecell/biochemistry/phoslidiag.gif
  • http://forums.pelicanparts.com/uploads14/phospholipidbilayer1236918969.jpg
  • http://scienceblogs.com/afarensis/upload/2006/03/lipidbilayer.gif What are some water soluble molecules?
  • http://www-3.unipv.it/webbio/anatcomp/freitas/2007-2008/cholesterol.jpg
  • http://bioweb.wku.edu/courses/biol115/wyatt/biochem/lipid/P-lipid.gif
  • http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/MembraneProteins.gif
  • http://www.biologycorner.com/resources/cell_membrane.jpg
  • http://www.biologycorner.com/resources/cell_membrane.jpg
  • http://www.ibiblio.org/virtualcell/textbook/chapter3/movies/pro5.gif
  • http://en.citizendium.org/images/thumb/0/05/Cell_membrane_-1.JPG/700px-Cell_membrane_-1.JPG

Transcript

  • 1. The Cell Membrane FOS 3 Infectious Disease Unit
  • 2. Composition of Cell Membrane
    • Cell Membranes are NOT all identical, but have FOUR common parts:
      • Lipid Bilayer
      • Transmembrane Protein
      • Network of supporting fibers
      • Glycoproteins
  • 3. Lipid Foundation- Phospholipid Bilayer
    • Consist of a:
      • Glycerol backbone
      • 2 Fatty Acid tails (nonpolar/
      • hydrophobic)
      • Phosphate Head (polar/hydrophilic)
  • 4. Lipid Foundation- Phospholipids
    • Fatty Acid side is NONPOLAR
      • Nonsoluble in water
    • Phosphate side is POLAR
      • Soluble in water
  • 5. Lipid Bilayer
    • Creates barrier to water soluble molecules
    • Lipid bilayer is fluid, yet stable.
  • 6. Fluid Mosaic Model
  • 7. History of the Fluid Mosaic Model
    • If you want more information of this go to:http://www1.umn.edu/ships/9-2/membrane.htm
  • 8. Controls the fluidity of the Cell Membrane
    • Temperature
    • Length of tails and kinks in tails
    • Cholesterol
  • 9. Cholesterol in Cell Membrane
    • The phospholipid bilayer also contains cholesterol molecules. This gives the layer greater strength, more flexibility, less fluid and less permeable to ions and monosaccharides.
  • 10. How do things get through if there is a barrier?
    • Simple diffusion.
    • Through “kinks” in the fatty acid tails
      • Closely aligned tails have C-C (single bonds)
      • C=C (double/triple bonds) cause “kinks”
  • 11. Protein Functions in the Membrane
    • Transmembrane
    • ID Markers
    • Receptors
    • Channels
    • Carrier
    • Cytoskeleton attachment and support
  • 12. Transmembrane Proteins extend across lipid bilayer
    • These proteins can have both a polar and a nonpolar region.
  • 13. Proteins act as Cell Identification Markers
    • Glycolipids and glycoproteins
    • Cell ID Markers
    • This is particularly important in the immune system
  • 14. Major Histocompatibility Complex
    • Unique to every individual
      • Except identical twins
    • Consists of proteins that attach to exterior cells and antigens
    • Allows T-Cells in the immune system to recognize and attack foreign cells
    • Glycolipids also differentiate between tissues of same individual
      • A, B, AB and O blood group markers.
  • 15. Cell Surface Receptors
  • 16. Channel Proteins
  • 17. Carrier Proteins
    • They do not extend through the membrane
    • They bond and drag molecules through the lipid bilayer and release them on the opposite side.
  • 18. Proteins used to attach Cytoskeleton
    • Receptor proteins help to attach the cytoskeleton inside the cell.
  • 19. Membrane Protein Functions Receptor
  • 20. Membrane Protein Functions