Your SlideShare is downloading. ×
Enzyme
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×

Introducing the official SlideShare app

Stunning, full-screen experience for iPhone and Android

Text the download link to your phone

Standard text messaging rates apply

Enzyme

833
views

Published on

Dr.Ehab Aboueladab

Dr.Ehab Aboueladab

Published in: Health & Medicine

0 Comments
2 Likes
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
833
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
51
Comments
0
Likes
2
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. Enzymes 1
  • 2. What Are Enzymes?• Most enzymes are Proteins (tertiary and quaternary structures)• Act as Catalyst to accelerates a reaction• Not permanently changed in the process 2
  • 3. Enzymes• Are specific for what they will catalyze• Are Reusable• End in –ase - Sucrase - Lactase - Maltase 3
  • 4. How do enzymes Work?Enzymes work by weakening bonds which lowers activation energy 4
  • 5. Enzymes Without Enzyme With EnzymeFree Free energy of activationEnergy Reactants Products Progress of the reaction 5
  • 6. 6
  • 7. Enzyme-Substrate ComplexThe substance (reactant) an enzyme acts on is the substrate Joins Substrate Enzyme 7
  • 8. Active Site• A restricted region of an enzyme molecule which binds to the substrate. Active Site Substrate Enzyme 8
  • 9. Induced Fit• A change in the shape of an enzyme’s active site• Induced by the substrate 9
  • 10. Induced Fit• A change in the configuration of an enzyme’s active site (H+ and ionic bonds are involved).• Induced by the substrate. Active Site substrate Enzyme induced fit 10
  • 11. What Affects Enzyme Activity?• Three factors: 1. Environmental Conditions 2. Cofactors and Coenzymes 3. Enzyme Inhibitors 11
  • 12. 1. Environmental Conditions1. Extreme Temperature are the mostdangerous- high temps may denature (unfold)the enzyme.2. pH (most like 6 - 8 pH nearneutral)3. Ionic concentration (salt ions) 12
  • 13. 2. Cofactors and Coenzymes• Inorganic substances (zinc, iron) and vitamins (respectively) are sometimes need for proper enzymatic activity.• Example: Iron must be present in the quaternary structure - hemoglobin in order for it to pick up oxygen. 13
  • 14. Two examples of Enzyme Inhibitorsa. Competitive inhibitors: are chemicals that resemble an enzyme’s normal substrate and compete with it for the active site. Substrate Enzyme Competitive inhibitor 14
  • 15. Inhibitorsb. Noncompetitive inhibitors: Inhibitors that do not enter the active site, but bind to another part of the enzyme causing the enzyme to change its shape, which in turn alters the active site. Substrate Noncompetitive Enzyme Inhibitor active site altered 15