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Dr.ehab lipid metabolism-1

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Transcript

  • 1. Lipid Metabolism
  • 2. Lipid Metabolism
  • 3. Lipid Metabolism
  • 4. Lipid Metabolism• Digestion - Hydrolysis Reaction
  • 5. Lipid Metabolism
  • 6. Lipid Metabolism
  • 7. Fatty Acid Oxidation• Initial Step: Requires an ATP to synthesize acetyl CoA with the fatty acid.
  • 8. Beta Oxidation
  • 9. Beta Oxidation
  • 10. Beta Oxidation
  • 11. Beta Oxidation
  • 12. Beta Oxidation
  • 13. Beta Oxidation
  • 14. Beta Oxidation
  • 15. Palmitic Acid Review
  • 16. Palmitic Acid -ATP Synthesis• Palmitic Acid is C-16• Initiating Step - requires 1 ATP (text says 2)• Step 1 - FAD into e.t.c. = 2 ATP• Step 3 - NAD+ into e.t.c. = 3 ATP• Total ATP per turn of spiral = 5 ATP• Example with Palmitic Acid = 16 carbons = 8 acetyl groups• Number of turns of fatty acid spiral = 8-1 = 7 turns• ATP from fatty acid spiral = 7 turns and 5 per turn = 35 ATP.• NET ATP from Fatty Acid Spiral = 35 - 1 = 34 ATP
  • 17. Palmitic Acid (C-16) -ATP Synthesis• NET ATP - Fatty Acid Spiral = 35 - 1 = 34 ATP• Review ATP - Citric Acid Cycle start with Acetyl CoA• Step ATP produced• 7 visible ATP 1• Step 4 (NAD+ to E.T.C.) 3• Step 6 (NAD+ to E.T.C.) 3• Step10 (NAD+ to E.T.C.) 3• Step 8 (FAD to E.T.C.) 2• NET 12 ATP per turn C.A.C.• 8 Acetyl CoA = 8 turns C.A.C.• 8 turns x 12 ATP/C.A.C. = 96 ATP• GRAND TOTAL 130 ATP
  • 18. Acetyl CoA
  • 19. Ketone Bodies
  • 20. Ketone Bodies
  • 21. Blood Glucose and Glucosuria
  • 22. Ketone Bodies
  • 23. Lipogenesis