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Portilla Nih Resources

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Presentation to the gathering of bioscience regions in Winston Salem, NC | Feb 2008.

Presentation to the gathering of bioscience regions in Winston Salem, NC | Feb 2008.

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Portilla Nih Resources Portilla Nih Resources Presentation Transcript

  • Partnering with the NIH: Research Resources Lili M. Portilla Office of Technology Transfer & Development National Heart, Lung, and Blood Institute National Institutes of Health WIRED Bioscience Institute February 5-6, 2008
  • What NIH Can Do for You:
    • Grants and Contracts
      • SBIR, STTR, RFA, RFP
    • Resources
      • Materials & Programs
    • Collaborations
      • CTAs, CRADAs and Research Collaborations
    • Search Engines & Databases
      • E.g. Synapse & Pipeline to Partnerships (P2P)
    • Licensing Opportunities
      • In FY06: 3400 + Patents & 1,300 + Licenses
  • What is Needed?
    • To Transform an Innovation into a Medical Product:
          • Target
          • Screening or Validation
          • Preclinical Data
          • Clinical Data
  • SCREENING
    • NCI Rapid Access to NCI Discovery Resources (R*A*N*D)
      • Anti-cancer drug research
      • Discovery of small molecule, biologics or natural product hits
      • HTS, modeling, target production, analog generation
      • http://dtp.nci.nih.gov/docs/rand/rand_index.html#contact
    • NCI Initiative for Chemical Genetics (ICG) at the Broad Institute
      • Training and access to compound libraries and HTS
      • http:// www.broad.harvard.edu/chembio/icg/overview/index.htm
  • SCREENING
    • NINDS High Throughput Drug Screening Service Facility for Neurodegeneration
    • Adapt assays for HTS and test against a large, diverse collection of compounds
      • http://www.ninds.nih.gov/funding/areas/technology_development/HTS_Facility.htm
    • NINDS Anticonvulsant Drug Development (ADD) Program
      • Screen compounds in models of epilepsy
      • http://www.ninds.nih.gov/funding/research/asp/index.htm#participate
  • SCREENING
    • Molecular Libraries Screening Center Network (MLSCN) of the NIH Roadmap
      • Perform HTS on assays provided by researchers
      • Maintain large library of small molecules
      • Perform optimization chemistry to produce chemical probes
      • http://nihroadmap.nih.gov/molecularlibraries
  • VALIDATION
    • NCI Early Detection Research Network
      • Proof of principle data for cancer biomarkers
        • http://edrn.nci.nih.gov/colops/assoc
      • Cancer biomarker validation studies
        • http://edrn.nci.nih.gov/colops/vsp
  • SCREENING AND PRE-CLINICAL
    • NIAID In Vitro and In Vivo Antiviral Screening Program (Includes Biodefense Related Pathogens)
      • Screening and animal models for the assessment of the efficacy and toxicity of potential therapeutic for viral infections.
      • Facilitates the identification of antiviral agents with the potential for treatment of viral infections of public health importance, e.g.:
        • Herpesviruses
        • Respiratory viruses
        • Hepatitis B virus, Hepatitis C virus
        • Papillomaviruses
        • Biodefense-related organisms
      • http://www3.niaid.nih.gov/research/topics/viral/resources.htm
      • http://www3.niaid.nih.gov/Biodefense/Research/invitro.htm
  • SCREENING & PRE-CLINICAL
    • NIAID Pre-Clinical Drug Development for AIDS Therapies
        • Drug Discovery / Basic Research
        • Animal Efficacy
        • Pharmacokinetics and Toxicology
        • Chemistry, Formulation, and Manufacturing
        • HIV Therapeutics
        • Immunologic Evaluations
        • SIV and SHIV Evaluations
        • TB Therapeutics
        • Topical Microbicides
      • http://www.niaid.nih.gov/daids/PDATguide/overview.htm
  • PRE-CLINICAL: RAID
    • Rapid Access to Intervention Development Programs Designed to bridge the gap between discovery and clinical trials
    • NCI RAID
      • Scope: Cancer therapeutic
      • http://dtp.nci.nih.gov/docs/raid/raid_index.html
    • T1D-RAID
      • Scope: Therapeutics for Type 1 Diabetes
      • http://www.niddk.nih.gov/fund/diabetesspecialfunds/T1D-RAID
    • NIH-RAID Pilot
      • Scope: Small molecule therapeutics
      • http://nihroadmap.nih.gov/raid/#summary
  • PRE-CLINICAL
    • NCI Nanotechnology Characterization Laboratory (NCL)
      • Characterization of physical attributes, pre-clinical efficacy and toxicity testing of nanoparticles intended for cancer therapy, imaging and diagnostics
      • http://ncl.cancer.gov/working_application-process.asp
  • PRE-CLINICAL
    • NCI Specialized Programs of Research Excellence (SPORE)
    • Developmental Research Program
      • Support for pilot projects with promising translational research potential to generate feasibility data
      • Conducted in collaboration with SPORE investigators
      • http://spores.nci.nih.gov/current/index_current.html
  • PRE-CLINICAL - CLINICAL
    • NCI Development of Clinical Imaging Drugs & Enhancers (DCIDE)
      • Cancer imaging enhancers or molecular probes
      • http://imaging.cancer.gov/programsandresources/specializedinitiatives/dcide
    • NCI Division of Cancer Prevention (DCP)
      • Prevention agents, statistical software, clinical trials management
      • http://www.cancer.gov/prevention/rapid/about.html
  • PRE-CLINIC - CLINICAL
    • NCI Cancer Therapy Evaluation Program
      • Resources, pre-clinical and clinical development of cancer therapeutics
      • NCI-held IND
      • http://ctep.cancer.gov/
  • PRE-CLINICAL - CLINICAL
    • NIDA Division of Pharmacotherapies and Medical Consequences of Drug Abuse
      • Addiction Treatment Discovery Program
      • Cocaine Clinical Trials Program
      • Opiate Clinical Trials Program
      • Methamphetamine Clinical Trial Group Program
        • http://www.nida.nih.gov/researchers.html
  • CLINICAL
    • NIAID Sponsored Collaborative Antiviral Study Group (CASG)
      • Multi-center clinical trials group conducts studies to evaluate novel antiviral therapies that target unmet medical needs. 
        • CASG conducts pediatric and adult research trials in over 100 clinical centers across the country and in select international sites. 
        • CASG also collaborates with pharmaceutical companies to evaluate new antiviral therapies
      • http://www.casg.uab.edu/index.htm
  • CLINICAL
    • NIAID Clinical Trial Mechanisms for the Development of AIDS Therapies
      • Available to investigators wishing to have their products/therapies tested in collaboration with one of the existing study groups.
        • Adult & Pediatric AIDS Clinical Trials Groups
        • Acute Infection and Early Disease Research Program
        • AIDS Malignancy Consortium
        • Collaborative Antiviral Study Group
        • Mycoses Study Group
        • Neurology AIDS Research Consortium
        • Novel HIV Therapies: Integrated Pre/Clinical Program
        • Studies of Ocular Complications of AIDS
      • http://www.niaid.nih.gov/daids/PDATguide/ctm.htm
  • CLINICAL
    • NCRR Clinical Research Resources
      • Ensures that specialized facilities and biological materials needed for patient-oriented research are accessible to biomedical investigators whose research projects are supported by the National Institutes of Health and other peer-reviewed sources
        • Clinical and Translational Science Awards
        • Clinical Research Informatics
        • General Clinical Research Centers
        • Genotyping and Analysis Center
        • National Gene Vector Laboratories
        • Islet Cell Resource Centers
        • Human Tissues and Organs Resource
        • Rare Disease Clinical Research Network
      • http://www.ncrr.nih.gov/clinical_research_resources/resource_directory/
  • NHLBI Resequencing and Genotyping Service http://rsng.nhlbi.nih.gov/scripts/index.cfm
    • NHLBI Sample Repository
    • http://www.nhlbi.nih.gov/resources/medres/reposit/reposit.htm
    • Production Assistance for Cellular Therapies (PACT)
    • http:// www.pactgroup.net
    • NHGRI and NIH Knock-out Mouse Project (KOMP)
    • http://www.genome.gov/ and http://www.nih.gov/science/model/mouse/knockout/
    • Genetically Altered Animal Models Related to Heart, Lung, Blood, or Sleep
    • http://www.nhlbi.nih.gov/resources/medres/transgen.htm
    Other NHLBI Resources
  • COLLABORATIONS
    • NIH Has Scientists in 19 Institutes:
      • Cancer (NCI)
      • Eye (NEI)
      • Heart, Lung, and Blood (NHLBI)
      • Human Genome Research (NHGRI)
      • Aging (NIA)
      • Alcohol Abuse and Alcoholism (NIAAA)
      • Allergy and Infectious Diseases (NIAID)
      • Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
      • Biomedical Imaging and Bioengineering (NIBIB)
      • Child Health and Human Development (NICHD)
      • Deafness and Other Communication Disorders (NIDCD)
      • Dental and Craniofacial Research (NIDCR)
      • Diabetes and Digestive and Kidney Diseases (NIDDK)
      • Drug Abuse (NIDA)
      • Environmental Health Sciences (NIEHS)
      • General Medical Sciences (NIGMS)
      • Mental Health (NIMH)
      • Neurological Disorders and Stroke (NINDS)
      • Nursing Research (NINR)
  • COLLABORATIONS
    • Many NIH Researchers are Interested in Collaborations with Outside Entities
      • NIH internal research specializes in basic science
      • We need to pass the resulting technologies to those able to bring benefits to public health
      • This can be achieved through:
        • Licensing an NIH technology
          • http://ott.od.nih.gov/licensing_royalties/techabs.html
        • Cooperative Research and Development Agreement (CRADA)
        • Research Collaboration Agreement (RCA)
        • Exchange of Material or Information (MTA, CDA, BMLA)
      • Contacting the TDC for the Institute concerned:
          • http://ott.od.nih.gov/nih_staff/tdc.html
  • Questions?
    • Lili M. Portilla
    • Office of Technology Transfer and Development
    • NHLBI, NIH, HHS
    • [email_address]
    • For copy of these slides and additional information send email with “ NIH Resources ” in Subject Line