Portilla Nih Resources

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Presentation to the gathering of bioscience regions in Winston Salem, NC | Feb 2008.

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  • Portilla Nih Resources

    1. 1. Partnering with the NIH: Research Resources Lili M. Portilla Office of Technology Transfer & Development National Heart, Lung, and Blood Institute National Institutes of Health WIRED Bioscience Institute February 5-6, 2008
    2. 2. What NIH Can Do for You: <ul><li>Grants and Contracts </li></ul><ul><ul><li>SBIR, STTR, RFA, RFP </li></ul></ul><ul><li>Resources </li></ul><ul><ul><li>Materials & Programs </li></ul></ul><ul><li>Collaborations </li></ul><ul><ul><li>CTAs, CRADAs and Research Collaborations </li></ul></ul><ul><li>Search Engines & Databases </li></ul><ul><ul><li>E.g. Synapse & Pipeline to Partnerships (P2P) </li></ul></ul><ul><li>Licensing Opportunities </li></ul><ul><ul><li>In FY06: 3400 + Patents & 1,300 + Licenses </li></ul></ul>
    3. 3. What is Needed? <ul><li>To Transform an Innovation into a Medical Product: </li></ul><ul><ul><ul><ul><li>Target </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Screening or Validation </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Preclinical Data </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Clinical Data </li></ul></ul></ul></ul>
    4. 4. SCREENING <ul><li>NCI Rapid Access to NCI Discovery Resources (R*A*N*D) </li></ul><ul><ul><li>Anti-cancer drug research </li></ul></ul><ul><ul><li>Discovery of small molecule, biologics or natural product hits </li></ul></ul><ul><ul><li>HTS, modeling, target production, analog generation </li></ul></ul><ul><ul><li>http://dtp.nci.nih.gov/docs/rand/rand_index.html#contact </li></ul></ul><ul><li>NCI Initiative for Chemical Genetics (ICG) at the Broad Institute </li></ul><ul><ul><li>Training and access to compound libraries and HTS </li></ul></ul><ul><ul><li>http:// www.broad.harvard.edu/chembio/icg/overview/index.htm </li></ul></ul>
    5. 5. SCREENING <ul><li>NINDS High Throughput Drug Screening Service Facility for Neurodegeneration </li></ul><ul><li>Adapt assays for HTS and test against a large, diverse collection of compounds </li></ul><ul><ul><li>http://www.ninds.nih.gov/funding/areas/technology_development/HTS_Facility.htm </li></ul></ul><ul><li>NINDS Anticonvulsant Drug Development (ADD) Program </li></ul><ul><ul><li>Screen compounds in models of epilepsy </li></ul></ul><ul><ul><li>http://www.ninds.nih.gov/funding/research/asp/index.htm#participate </li></ul></ul>
    6. 6. SCREENING <ul><li>Molecular Libraries Screening Center Network (MLSCN) of the NIH Roadmap </li></ul><ul><ul><li>Perform HTS on assays provided by researchers </li></ul></ul><ul><ul><li>Maintain large library of small molecules </li></ul></ul><ul><ul><li>Perform optimization chemistry to produce chemical probes </li></ul></ul><ul><ul><li>http://nihroadmap.nih.gov/molecularlibraries </li></ul></ul>
    7. 7. VALIDATION <ul><li>NCI Early Detection Research Network </li></ul><ul><ul><li>Proof of principle data for cancer biomarkers </li></ul></ul><ul><ul><ul><li>http://edrn.nci.nih.gov/colops/assoc </li></ul></ul></ul><ul><ul><li>Cancer biomarker validation studies </li></ul></ul><ul><ul><ul><li>http://edrn.nci.nih.gov/colops/vsp </li></ul></ul></ul>
    8. 8. SCREENING AND PRE-CLINICAL <ul><li>NIAID In Vitro and In Vivo Antiviral Screening Program (Includes Biodefense Related Pathogens) </li></ul><ul><ul><li>Screening and animal models for the assessment of the efficacy and toxicity of potential therapeutic for viral infections. </li></ul></ul><ul><ul><li>Facilitates the identification of antiviral agents with the potential for treatment of viral infections of public health importance, e.g.: </li></ul></ul><ul><ul><ul><li>Herpesviruses </li></ul></ul></ul><ul><ul><ul><li>Respiratory viruses </li></ul></ul></ul><ul><ul><ul><li>Hepatitis B virus, Hepatitis C virus </li></ul></ul></ul><ul><ul><ul><li>Papillomaviruses </li></ul></ul></ul><ul><ul><ul><li>Biodefense-related organisms </li></ul></ul></ul><ul><ul><li>http://www3.niaid.nih.gov/research/topics/viral/resources.htm </li></ul></ul><ul><ul><li>http://www3.niaid.nih.gov/Biodefense/Research/invitro.htm </li></ul></ul>
    9. 9. SCREENING & PRE-CLINICAL <ul><li>NIAID Pre-Clinical Drug Development for AIDS Therapies </li></ul><ul><ul><ul><li>Drug Discovery / Basic Research </li></ul></ul></ul><ul><ul><ul><li>Animal Efficacy </li></ul></ul></ul><ul><ul><ul><li>Pharmacokinetics and Toxicology </li></ul></ul></ul><ul><ul><ul><li>Chemistry, Formulation, and Manufacturing </li></ul></ul></ul><ul><ul><ul><li>HIV Therapeutics </li></ul></ul></ul><ul><ul><ul><li>Immunologic Evaluations </li></ul></ul></ul><ul><ul><ul><li>SIV and SHIV Evaluations </li></ul></ul></ul><ul><ul><ul><li>TB Therapeutics </li></ul></ul></ul><ul><ul><ul><li>Topical Microbicides </li></ul></ul></ul><ul><ul><li>http://www.niaid.nih.gov/daids/PDATguide/overview.htm </li></ul></ul>
    10. 10. PRE-CLINICAL: RAID <ul><li>Rapid Access to Intervention Development Programs Designed to bridge the gap between discovery and clinical trials </li></ul><ul><li>NCI RAID </li></ul><ul><ul><li>Scope: Cancer therapeutic </li></ul></ul><ul><ul><li>http://dtp.nci.nih.gov/docs/raid/raid_index.html </li></ul></ul><ul><li>T1D-RAID </li></ul><ul><ul><li>Scope: Therapeutics for Type 1 Diabetes </li></ul></ul><ul><ul><li>http://www.niddk.nih.gov/fund/diabetesspecialfunds/T1D-RAID </li></ul></ul><ul><li>NIH-RAID Pilot </li></ul><ul><ul><li>Scope: Small molecule therapeutics </li></ul></ul><ul><ul><li>http://nihroadmap.nih.gov/raid/#summary </li></ul></ul>
    11. 11. PRE-CLINICAL <ul><li>NCI Nanotechnology Characterization Laboratory (NCL) </li></ul><ul><ul><li>Characterization of physical attributes, pre-clinical efficacy and toxicity testing of nanoparticles intended for cancer therapy, imaging and diagnostics </li></ul></ul><ul><ul><li>http://ncl.cancer.gov/working_application-process.asp </li></ul></ul>
    12. 12. PRE-CLINICAL <ul><li>NCI Specialized Programs of Research Excellence (SPORE) </li></ul><ul><li>Developmental Research Program </li></ul><ul><ul><li>Support for pilot projects with promising translational research potential to generate feasibility data </li></ul></ul><ul><ul><li>Conducted in collaboration with SPORE investigators </li></ul></ul><ul><ul><li>http://spores.nci.nih.gov/current/index_current.html </li></ul></ul>
    13. 13. PRE-CLINICAL - CLINICAL <ul><li>NCI Development of Clinical Imaging Drugs & Enhancers (DCIDE) </li></ul><ul><ul><li>Cancer imaging enhancers or molecular probes </li></ul></ul><ul><ul><li>http://imaging.cancer.gov/programsandresources/specializedinitiatives/dcide </li></ul></ul><ul><li>NCI Division of Cancer Prevention (DCP) </li></ul><ul><ul><li>Prevention agents, statistical software, clinical trials management </li></ul></ul><ul><ul><li>http://www.cancer.gov/prevention/rapid/about.html </li></ul></ul>
    14. 14. PRE-CLINIC - CLINICAL <ul><li>NCI Cancer Therapy Evaluation Program </li></ul><ul><ul><li>Resources, pre-clinical and clinical development of cancer therapeutics </li></ul></ul><ul><ul><li>NCI-held IND </li></ul></ul><ul><ul><li>http://ctep.cancer.gov/ </li></ul></ul>
    15. 15. PRE-CLINICAL - CLINICAL <ul><li>NIDA Division of Pharmacotherapies and Medical Consequences of Drug Abuse </li></ul><ul><ul><li>Addiction Treatment Discovery Program </li></ul></ul><ul><ul><li>Cocaine Clinical Trials Program </li></ul></ul><ul><ul><li>Opiate Clinical Trials Program </li></ul></ul><ul><ul><li>Methamphetamine Clinical Trial Group Program </li></ul></ul><ul><ul><ul><li>http://www.nida.nih.gov/researchers.html </li></ul></ul></ul>
    16. 16. CLINICAL <ul><li>NIAID Sponsored Collaborative Antiviral Study Group (CASG) </li></ul><ul><ul><li>Multi-center clinical trials group conducts studies to evaluate novel antiviral therapies that target unmet medical needs.  </li></ul></ul><ul><ul><ul><li>CASG conducts pediatric and adult research trials in over 100 clinical centers across the country and in select international sites.  </li></ul></ul></ul><ul><ul><ul><li>CASG also collaborates with pharmaceutical companies to evaluate new antiviral therapies </li></ul></ul></ul><ul><ul><li>http://www.casg.uab.edu/index.htm </li></ul></ul>
    17. 17. CLINICAL <ul><li>NIAID Clinical Trial Mechanisms for the Development of AIDS Therapies </li></ul><ul><ul><li>Available to investigators wishing to have their products/therapies tested in collaboration with one of the existing study groups. </li></ul></ul><ul><ul><ul><li>Adult & Pediatric AIDS Clinical Trials Groups </li></ul></ul></ul><ul><ul><ul><li>Acute Infection and Early Disease Research Program </li></ul></ul></ul><ul><ul><ul><li>AIDS Malignancy Consortium </li></ul></ul></ul><ul><ul><ul><li>Collaborative Antiviral Study Group </li></ul></ul></ul><ul><ul><ul><li>Mycoses Study Group </li></ul></ul></ul><ul><ul><ul><li>Neurology AIDS Research Consortium </li></ul></ul></ul><ul><ul><ul><li>Novel HIV Therapies: Integrated Pre/Clinical Program </li></ul></ul></ul><ul><ul><ul><li>Studies of Ocular Complications of AIDS </li></ul></ul></ul><ul><ul><li>http://www.niaid.nih.gov/daids/PDATguide/ctm.htm </li></ul></ul>
    18. 18. CLINICAL <ul><li>NCRR Clinical Research Resources </li></ul><ul><ul><li>Ensures that specialized facilities and biological materials needed for patient-oriented research are accessible to biomedical investigators whose research projects are supported by the National Institutes of Health and other peer-reviewed sources </li></ul></ul><ul><ul><ul><li>Clinical and Translational Science Awards </li></ul></ul></ul><ul><ul><ul><li>Clinical Research Informatics </li></ul></ul></ul><ul><ul><ul><li>General Clinical Research Centers </li></ul></ul></ul><ul><ul><ul><li>Genotyping and Analysis Center </li></ul></ul></ul><ul><ul><ul><li>National Gene Vector Laboratories </li></ul></ul></ul><ul><ul><ul><li>Islet Cell Resource Centers </li></ul></ul></ul><ul><ul><ul><li>Human Tissues and Organs Resource </li></ul></ul></ul><ul><ul><ul><li>Rare Disease Clinical Research Network </li></ul></ul></ul><ul><ul><li>http://www.ncrr.nih.gov/clinical_research_resources/resource_directory/ </li></ul></ul>
    19. 19. NHLBI Resequencing and Genotyping Service http://rsng.nhlbi.nih.gov/scripts/index.cfm
    20. 20. <ul><li>NHLBI Sample Repository </li></ul><ul><li>http://www.nhlbi.nih.gov/resources/medres/reposit/reposit.htm </li></ul><ul><li>Production Assistance for Cellular Therapies (PACT) </li></ul><ul><li>http:// www.pactgroup.net </li></ul><ul><li>NHGRI and NIH Knock-out Mouse Project (KOMP) </li></ul><ul><li>http://www.genome.gov/ and http://www.nih.gov/science/model/mouse/knockout/ </li></ul><ul><li>Genetically Altered Animal Models Related to Heart, Lung, Blood, or Sleep </li></ul><ul><li>http://www.nhlbi.nih.gov/resources/medres/transgen.htm </li></ul>Other NHLBI Resources
    21. 21. COLLABORATIONS <ul><li>NIH Has Scientists in 19 Institutes: </li></ul><ul><ul><li>Cancer (NCI) </li></ul></ul><ul><ul><li>Eye (NEI) </li></ul></ul><ul><ul><li>Heart, Lung, and Blood (NHLBI) </li></ul></ul><ul><ul><li>Human Genome Research (NHGRI) </li></ul></ul><ul><ul><li>Aging (NIA) </li></ul></ul><ul><ul><li>Alcohol Abuse and Alcoholism (NIAAA) </li></ul></ul><ul><ul><li>Allergy and Infectious Diseases (NIAID) </li></ul></ul><ul><ul><li>Arthritis and Musculoskeletal and Skin Diseases (NIAMS) </li></ul></ul><ul><ul><li>Biomedical Imaging and Bioengineering (NIBIB) </li></ul></ul><ul><ul><li>Child Health and Human Development (NICHD) </li></ul></ul><ul><ul><li>Deafness and Other Communication Disorders (NIDCD) </li></ul></ul><ul><ul><li>Dental and Craniofacial Research (NIDCR) </li></ul></ul><ul><ul><li>Diabetes and Digestive and Kidney Diseases (NIDDK) </li></ul></ul><ul><ul><li>Drug Abuse (NIDA) </li></ul></ul><ul><ul><li>Environmental Health Sciences (NIEHS) </li></ul></ul><ul><ul><li>General Medical Sciences (NIGMS) </li></ul></ul><ul><ul><li>Mental Health (NIMH) </li></ul></ul><ul><ul><li>Neurological Disorders and Stroke (NINDS) </li></ul></ul><ul><ul><li>Nursing Research (NINR) </li></ul></ul>
    22. 22. COLLABORATIONS <ul><li>Many NIH Researchers are Interested in Collaborations with Outside Entities </li></ul><ul><ul><li>NIH internal research specializes in basic science </li></ul></ul><ul><ul><li>We need to pass the resulting technologies to those able to bring benefits to public health </li></ul></ul><ul><ul><li>This can be achieved through: </li></ul></ul><ul><ul><ul><li>Licensing an NIH technology </li></ul></ul></ul><ul><ul><ul><ul><li>http://ott.od.nih.gov/licensing_royalties/techabs.html </li></ul></ul></ul></ul><ul><ul><ul><li>Cooperative Research and Development Agreement (CRADA) </li></ul></ul></ul><ul><ul><ul><li>Research Collaboration Agreement (RCA) </li></ul></ul></ul><ul><ul><ul><li>Exchange of Material or Information (MTA, CDA, BMLA) </li></ul></ul></ul><ul><ul><li>Contacting the TDC for the Institute concerned: </li></ul></ul><ul><ul><ul><ul><li>http://ott.od.nih.gov/nih_staff/tdc.html </li></ul></ul></ul></ul>
    23. 23. Questions? <ul><li>Lili M. Portilla </li></ul><ul><li>Office of Technology Transfer and Development </li></ul><ul><li>NHLBI, NIH, HHS </li></ul><ul><li>[email_address] </li></ul><ul><li>For copy of these slides and additional information send email with “ NIH Resources ” in Subject Line </li></ul>
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