Sonia Flores Seminar

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Sonia Flores Seminar

  1. 1. Eduardo E. RiveraDr. Sonia FloresPulmonary Hypertension Associated with HIVDr. Sonia Flores talked in her seminar about the association that there may be withHIV infection and pulmonary infection. The incidence of pulmonary arterialhypertension is much higher in HIV infected individuals than in the generalpopulation. In their lab they wanted to figure out what is the connection betweenHIV and pulmonary hypertension. For this study they used non-human primatemodels that already have the HIV infection. They used HI V-1 Nef gene and foundout that Nef is highly immunogenic and essential for pathogenesis of aids.However,they also found that in two HIV infected patients with pulmonary hypertensioncontained Nef. Nef was only found when a patient had HIV and pulmonaryhypertension. By this said they hypothesized that various changes in the amino acidsequence of Nef in patients with pulmonary hypertension would change vascularendothelial and smooth muscle cell physiology. After conducting various studies ofHIV pathogenesis the results suggested that different Nef alleles have different effecton CD4 downregulation.

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