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Lombardi comprehensive cancer center Georgetown

Lombardi comprehensive cancer center Georgetown






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    Lombardi comprehensive cancer center Georgetown Lombardi comprehensive cancer center Georgetown Presentation Transcript

    • Lombardi Comprehensive Cancer Center Cancer Informatics Summit 2/21/2013 Subha Madhavan, Ph.D. Director, Innovation Center for Biomedical Informatics Georgetown University Medical Center Director, Clinical Research Informatics Lombardi Comprehensive Cancer Center
    • Vincent T. Lombardi • Famous professional football coach • Fell ill at Washington Redskins’ practice on Georgetown University field • Treated for cancer at Georgetown “Winning isn’t everything, it’s the only thing.” • Cancer Center named in his honor
    • Lombardi – At a glance • Established in 1970 • In 1974, Georgetown Lombardi became the 16th NCI-designated Comprehensive Cancer Center • Over $100M in research funding ever year – $35M CCSG + peer-reviewed funding base • 94 full members; 186 cancer-connected faculty members • 4 Research programs & 9 Shared resources • 220 ongoing trials
    • Key Accomplishments • Development of human papillomavirus (HPV) vaccine to prevent cervical cancer – R. Schlegel • Discovery of GADD-4 DNA repair gene – A. Fornace • Nuclear hormone receptor networks in breast cancer – R. Clarke • Monoclonal antibody therapy – L. Weiner
    • General Organizational Structure Director (Weiner) Deputy Director (Atkins) Clinical Care (Marshall) Clinical Research (Giaccone) Population Sciences (Mandelblatt) Basic Research (Wellstein) Minority Health (Campbell) Shared Resources (Byers) Administration (VanderHoek)
    • Another view of the cancer center IAC EAC Director Deputy Dir Community Advisory Council AD Basic/Transl Network Representative Administration Research Education MO CPC BC ET Trial Oversight AD Clinical Shared Resources AD Administration AD Minority Health AD Population AD Shared Resources
    • Informatics @ Georgetown
    • Innovation Center for Biomedical Informatics (ICBI) http://icbi.georgetown.edu/ • • • • • • Faculty – 5 Senior staff members – 5 Research associates – 5 Support staff – 2 Consultants – 5 Students/Trainees - 2 Expertise in bioinformatics, clinical informatics, biomathematics, biostatistics, clinical genomics, molecular biology, high-throughput molecular assays, enterprise class software development, data management, data security, & project management
    • Informatics Org Chart Cancer Center Director CCSG SR Director CTSA PI Dean of Research ICBI Director Director, Operations Office Manager Highthroughput omics Financial Analyst Communications/ Scientific writing Technology Development Health IT ChemiInformatics Data Coordination & Biocuration FTEs supporting Cancer Center – 8 Total FTEs - 22 Clinical Research Informatics
    • Informatics Funding $3.5M Total Annual Funding in 2012
    • Lombardi Information Architecture (current & future)
    • Integrated Data Environment: G-DOC Links to Many of Data Silos Pathway Studio Cytoscape • Systems biology • Literature •Visualization networks JMol/Marvin Ingenuity Analysis • Molecule Visualization •Pathways, GO, Variants G-DOC RedCap Clinical Research JBrowse •Genome Visualization Disease Classification Tools EHR’s
    • https://gdoc.georgetown.edu Over 330 registered users from six countries ~250 unique hits/month
    • Making Patients Part of Healthcare Through Technology Innovations
    • Next Generation Sequencing Big Data Analytics on the Cloud Genomic Data De-identified Clinical data PC User Genome Data Amazon S3 Bucket Amazon EC2 Compute Instances G-DOC Web Portal Clinical Data Amazon Glacier Vault MongoDB EC2 Instances Oracle RDS Instance
    • Informatics for Discovery, Clinical Research, Clinical Care • ‘omics’ data analysis Clinical Research Clinical Education • EHR/PHR integration • Informatics education • Biomarker discovery • Partnerships • Disease classification • Joint grants • Genotype-Phenotype correlation • Contracted services • Biospecimen management and analysis • Medical internships • Joint appointments • Shared resources • Shared IP • Technology/method development • Joint publications Basic/Traslational Biospecimen Website : https://icbi.georgetown.edu Email : icbi@georgetown.edu
    • Challenges & Opportunities Major Challenges:  Diverse set of policies and regulations across participating institutions  Lack of resources (human and IT)  Multiple clinical & research information silo’es Significant Opportunities/Strengths:      Technology development Community engagement Test bed for innovation ‘omics’ methods & integration Collaborations with CTSA