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Meningiomas
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Meningiomas

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  • 1. Meningiomas
    • Benign tumors of adults
    • Attached to dura– arise from meningothelial cells of arachnoid
    • Multiple meningioma ,Acoustic schwannoma , glioma(ependymoma)
    • --NF 2
    • 50% not associated with NF2 will have 22q mutation of the gene
  • 2. Morphology of meningioma
    • Grow as well defined dural based masses that compress the underlying brain but are easily seperated from it
    • Extedns to bone
    • Histo patterns
    • Syncitial-whorled clusters of cells
    • Fibroblastic - elongated cells with abundent fibroblast deposition between
    • Transitional- between s & t
    • Psammomatous
    • Secretory – PAS + intra cytoplasmic droplets
    • microcystic
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