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Bacillus

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  • 1. Bacillus Aerobic bacilli-B.anthracis Anerobic bacilli-Clostredium tetani
  • 2. Bacillu anthracis
    • Gram +ve
    • Aerobic spore bearing bacilli
    • Thermophilic and psuchrophilic
    • B.cereus-food borne gastroenteritis
    • Produces endospores
  • 3.
    • First bacterium observed under microscope
    • First communicable d/s transmitted by inoculation of infected blood
    • First to be isolated In pure culture and used for the preperation of attenuated vaccine
    • Used in biological warfere
    • One of the largest pathogenic bacteria
    • Capsulated PP capsule
    • M’Fadyean’s reaction-Polychrome methylene blue for few seconds-purplish material around the bacillus
    • Bamboo stick appearences
    • Nonmotile
    • Spores – central /terminal
  • 4. Culture
    • Agar plates –frost glass appearance
    • Low power –medusa plate appearance
    • Gelatin stab culture-inverted fir tree
    • Blood agar-nonhemolytic
    • Selective medium-PLET medium-
  • 5. Virulence factors
    • Capsular PP
    • Anthra toxin
    • Pathogenicity testing by inoculation into guinea pigs
  • 6. Anthrax
    • Zoonosis
    • Human d/s from animal-direct /indirect
    • d/s may be
    • Cutaneous
    • Pulmonary
    • Intestinal
    • All leading to fatal septicemia/meningitis
  • 7. Cutaneous
    • Entry thru skin
    • Satellite lasions arranged around a central necrotic lesion which is coverd by a black eschar- the name anthrax meaning coal comes from the black colour of eschar
    • These lesions are called Malignant pustules
    • Hide porter’s d/s-common in dock workers-carrying loads and skins on their bare back.
    • Generally resolves spaontaneously
  • 8. Pulmonary
    • Wool sorte’s d/s
    • Inhalation of infected wool particles
    • Haemorrhagic pneumonia with high fatality rates
    • Haemorrhagic meningitis is a main complication
  • 9. Intestinal
    • Rare
    • Violent enteritis
    • Bloody diarrhoea
    • Primitive communities who eat carcasses of animals
  • 10. Lab d/g
    • Microscopy, culture,M’fadyeans reaction
    • Serology-CFT,ELISA
    • Ascol’s thermo precipitation test-demonstration of anthrax antigen in tissue extracts
    • Nucleic acid detection
  • 11. Treatment
    • DOC-Penicillin
    • Streptomycin
    • Doxycycline
  • 12. Prophylaxis
    • Improvement of factory hygiene
    • Proper sterilization
    • Proper disposal of animal carcasses
    • Vaccination of animals