Actinomycetes

6,435 views

Published on

Published in: Technology, Health & Medicine
0 Comments
5 Likes
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
6,435
On SlideShare
0
From Embeds
0
Number of Embeds
10
Actions
Shares
0
Downloads
329
Comments
0
Likes
5
Embeds 0
No embeds

No notes for slide

Actinomycetes

  1. 1. Actinomycetes Fungi like bacteria Gram +ve
  2. 3. <ul><li>Gram +ve,nonmotile, none sporing,noncapsulated,filaments that break up into bacillary and coccoid elements </li></ul><ul><li>Medically imp- </li></ul><ul><li>Actinomyces -anerobic,non acid fast-grows only in a narrow range of temp. </li></ul><ul><li>Nocardia -aerobic, acidfast –grows in a wide range of temp. </li></ul><ul><li>Streptomyces -antibiotics </li></ul>
  3. 4. Actinomyces ---ray fungus <ul><li>Due to ray like appearance of the organisms in the granules </li></ul><ul><li>Human actinomycosis—A.israeli </li></ul><ul><li>Cattle—A.bovis </li></ul>
  4. 5. Actinomycosis <ul><li>C/C granulomatous infection </li></ul><ul><li>Indurated swelling in connective tissue,suppuration,discharge of sulphur granules </li></ul><ul><li>Leasion often points to skin,leading to multiple sinuses </li></ul><ul><li>Endogenous inf. In humans—normally present in mouth ,intestine,etc---- </li></ul><ul><li>Trauma,FB,poor oral hygeine--- </li></ul>
  5. 6. <ul><li>A.israeli-most common causative agent </li></ul><ul><li>Usually cooperative d/s-associated with other bacteria </li></ul><ul><li>Four main clinical forms </li></ul><ul><li>Cervicofacial-indurated lesions on cheek and submaxillary regions </li></ul><ul><li>Thoracic-laesions in lungs,pleura,pericardium,chest wall </li></ul><ul><li>Abdominal—around caecum,abdominal wall,liver </li></ul><ul><li>Pelvic—associated with use of IUD </li></ul><ul><li>Gingivitis,peridontitis </li></ul>
  6. 7. <ul><li>Lab d/g-microscopy </li></ul><ul><li>Sulphur granules—in pus—demo-shaking in tt with saline-on standing granules sediment </li></ul><ul><li>Granules –also by applying gauze pad over sinuses </li></ul><ul><li>Yellowish colour-stained by gram </li></ul><ul><li>Infact—bacterial colonies—densenetwork of thin gram +ve filaments,surronded by peripheral zone of swollen radiating club shaped structures-which r believed to be antigen-antibody complexes </li></ul>
  7. 8. <ul><li>In thioglycollate—A.israeli produces small spidary colonies </li></ul><ul><li>Epidemiology-in agricultural workers---young males </li></ul><ul><li>T/T-Penicillin in large doses/tetracycline </li></ul>
  8. 9. Nocardia <ul><li>Infection exogenous </li></ul><ul><li>Causes –cutaneous,subcutaneous,systemic lesions </li></ul><ul><li>N.asteroides </li></ul><ul><li>N.brasiliensis </li></ul><ul><li>N.caviae </li></ul>
  9. 10. <ul><li>Cutaneous-local abcess,cellulitis,lymphocutaneous lesions </li></ul><ul><li>Sub cutaneous-Actinomycotic mycetoma </li></ul><ul><li>Systemic –caused by N.asteroids—pulmonary d/s ,pneumonia,lung abcess—lesion resembling TB </li></ul><ul><li>Colonies—pigment-yellow to red </li></ul><ul><li>T/t- cotremoxazole-for several months </li></ul><ul><li>Minocycline </li></ul><ul><li>Amikacine </li></ul><ul><li>cefotaxime </li></ul>
  10. 11. Actinomycotic mycetoma <ul><li>Presents as tumour with multiple dischargimg sinuses </li></ul><ul><li>Localised granulomatous d/s of subcutaneous,and deeper tissues </li></ul><ul><li>Esp, foot </li></ul><ul><li>Also known as Maduramycosis </li></ul><ul><li>Can be caused by fungi and bacteria </li></ul><ul><li>Botryomycosis-similar lesion if caused by staph aureus and other pyogenic org. </li></ul>
  11. 12. <ul><li>Bacterial mycetomas-by actinomyces,nocardia </li></ul><ul><li>In actinomycotic—granules-white to yellow-filaments -thin </li></ul><ul><li>In eumycotic—granules –black---filaments-stout </li></ul>

×