Actinomycetes
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Actinomycetes Presentation Transcript

  • 1. Actinomycetes Fungi like bacteria Gram +ve
  • 2.  
  • 3.
    • Gram +ve,nonmotile, none sporing,noncapsulated,filaments that break up into bacillary and coccoid elements
    • Medically imp-
    • Actinomyces -anerobic,non acid fast-grows only in a narrow range of temp.
    • Nocardia -aerobic, acidfast –grows in a wide range of temp.
    • Streptomyces -antibiotics
  • 4. Actinomyces ---ray fungus
    • Due to ray like appearance of the organisms in the granules
    • Human actinomycosis—A.israeli
    • Cattle—A.bovis
  • 5. Actinomycosis
    • C/C granulomatous infection
    • Indurated swelling in connective tissue,suppuration,discharge of sulphur granules
    • Leasion often points to skin,leading to multiple sinuses
    • Endogenous inf. In humans—normally present in mouth ,intestine,etc----
    • Trauma,FB,poor oral hygeine---
  • 6.
    • A.israeli-most common causative agent
    • Usually cooperative d/s-associated with other bacteria
    • Four main clinical forms
    • Cervicofacial-indurated lesions on cheek and submaxillary regions
    • Thoracic-laesions in lungs,pleura,pericardium,chest wall
    • Abdominal—around caecum,abdominal wall,liver
    • Pelvic—associated with use of IUD
    • Gingivitis,peridontitis
  • 7.
    • Lab d/g-microscopy
    • Sulphur granules—in pus—demo-shaking in tt with saline-on standing granules sediment
    • Granules –also by applying gauze pad over sinuses
    • Yellowish colour-stained by gram
    • Infact—bacterial colonies—densenetwork of thin gram +ve filaments,surronded by peripheral zone of swollen radiating club shaped structures-which r believed to be antigen-antibody complexes
  • 8.
    • In thioglycollate—A.israeli produces small spidary colonies
    • Epidemiology-in agricultural workers---young males
    • T/T-Penicillin in large doses/tetracycline
  • 9. Nocardia
    • Infection exogenous
    • Causes –cutaneous,subcutaneous,systemic lesions
    • N.asteroides
    • N.brasiliensis
    • N.caviae
  • 10.
    • Cutaneous-local abcess,cellulitis,lymphocutaneous lesions
    • Sub cutaneous-Actinomycotic mycetoma
    • Systemic –caused by N.asteroids—pulmonary d/s ,pneumonia,lung abcess—lesion resembling TB
    • Colonies—pigment-yellow to red
    • T/t- cotremoxazole-for several months
    • Minocycline
    • Amikacine
    • cefotaxime
  • 11. Actinomycotic mycetoma
    • Presents as tumour with multiple dischargimg sinuses
    • Localised granulomatous d/s of subcutaneous,and deeper tissues
    • Esp, foot
    • Also known as Maduramycosis
    • Can be caused by fungi and bacteria
    • Botryomycosis-similar lesion if caused by staph aureus and other pyogenic org.
  • 12.
    • Bacterial mycetomas-by actinomyces,nocardia
    • In actinomycotic—granules-white to yellow-filaments -thin
    • In eumycotic—granules –black---filaments-stout