Erythroplasia of Queyrat (Bowen’s dis. of glans penis)
10% 6-17% 5-11% SCC 30%
Seborrheic keratosis One or more sharply defined, light brown to black, slightly raised lesions (as if stuck on surface) with soft velvety or finely verrucous surface. It occurs on trunk, face or extremities. Treatment 1. Removal with a small sharp curette. 2. Freezing. 3. TCA. 4. Cauterization.
Epidermal nevi They are circumscribed hamartomatous lesions composed only of keratinocytes. They present usually at birth or shortly later. I) Localized type“Nevus Unius Lateris” II) Systematized type“Ichthyosis hystrix”
It occurs unilaterally on the areola & nipple as a sharply defined, slightly infiltrated area of erythema showing scaling, oozing & crusting. Ulceration or retraction of the nipple may be found.
It is commonly associated with intraductal carcinoma of the breast.
Paget’s disease of the breast (Cont’d) Origin of Paget cells
The glandular origin was supported by immuno-histochemical studies, e.g. carcinoembryogenic antigen is found in Paget cells which is found also in normal apocrine & eccrine glands but not in keratinocytes or melanocytes.