1 김은정과장님

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1 김은정과장님

  1. 1. Dr. Eun Jung KIMNIFDS, KFDA, KOREA
  2. 2.  Current trends in researches of intestinal microflora What is interest in intestinal microflora research? Introduction of Fundamental Study of Drug Metabolism Research Group in NIFDS Current Achievements Future Prospectives
  3. 3.  Research program ◦ food safety, food biosecurity, and methods development ◦ antimicrobial resistance in foodborne and commensal bacteria ◦ intestinal microflora and host interactions ◦ environmental biotechnology ◦ microbiological surveillance and diagnostic support of research Ongoing research projects involved in intestinal microflora ◦ evaluation of the mechanisms of inactivation and degradation of third-ge neration cephalosporins by the bovine intestinal microflora ◦ impact of antimicrobial residues on the human gastrointestinal tract Micr obiota
  4. 4.  Unit for Ecology and Physiology of the Digestive Tract (UEPSD) • Researches on the roles of microflora on food transformation in intestine • Analysis of microfloral enzymes related to metabolism and digestion of food • Functional genomic- and metagenomic researches on intestinal microflora
  5. 5.  Department of gastro-intestinal microbiology Field of research  To elucidate the influence of gastrointestin al microbiota on human health. Goal  To characterize microorganisms of the gastrointestinal tract  To demonstrate their physiological and pathophysiological roles
  6. 6.  “The second Human Genome Project” ◦ USA : Human Microbiome Project ◦ EU : MetaHIT ◦ France : MicroObes ◦ Austria : Australian Urogenital Microbiome Consrotium ◦ Canada : Canadian Microbiome Initiative ◦ China : Meta-GUT ◦ Japan : Human Metagenome Contium ◦ Singapore : Human Gastric Microbiome ◦ International : International Human Microbiome Project
  7. 7.  Goal ◦ To work under a common set of principles and policies to study and understand the role of the human microbiome health and causation of disease ◦ To use that knowledge to improve the ability to prevent and treat disease Full Members ◦ Canadian Institutes of Health Research (Canada) ◦ European Commission (Europe) ◦ Institut National de la Recherche Agronomique (France) ◦ Japan Science & Technology Agency, JST (Japan) ◦ National Institutes of Health (United States of America) ◦ Commonwealth Scientific and Industrial Research Organisation (Australia) ◦ Medical Research Council (Gambia)
  8. 8. Host Influences in Gut MicrobialEcology • Age • Diet, Drugs • Environmental • Genetics • Defense mechanism • Stress responses
  9. 9. What is interest in intestinal microflora research?  Intestinal microflora as a new biological resource for future • Only 1 % of intestinal microflora were currently identified, whereas the rest 99% were not yet identified • Intestinal microflora have great value as resources for biotech industries  To Promote domestic researches on intestinal microflora • Organize a nation-wide research consortium for intenstinal microflora to promote a international collaboration such as human microbiome  Importance of researches on Korean specific intestinal microflora • Diversity of intestinal microflora- highly depending on age, diet, health and environment conditions • Korean has highly different dietary habit and life styles - high expectation for microflora difference
  10. 10. Synopsis of the Research Group Program : Research group for Fundamental Study of Drug • Total Budget : 2.5 billion won ( ~2 million US $) • Duration : 3 years (2009~11) • Principal Investigator of the Program : Professor Dong Hyun KIM (KyungHee Univ.) • Program Organizer : Dr. Eun Jung KIM (Pharmacology Research Division, NIFDS) • Chairman of Program Advisory Committee : Professor Eungchil CHOI (Seoul National Univ.)
  11. 11. Advisiory Research Group for Fundamental Program Committee study of drug metabolism Organizer Program 1 Program 2 Program 3Development of toxicological assays using Researches on metabolic activity of intestinal Identification and analysis of Korean intestinal microflora microflora specific intestinal microflora Research project 1-1 Research project 2-1 Research project 3-1 Development of metabolite toxicity Identification of metaboites and their toxic Standardization for Korean specific testing by using intestinal microflora metabolism pathways by intestinal intestinal microflora through isolation cultures microflora and identification of anaerobic bacteria Research project 1-2 Research project 2-2 Research project 3-2 Development of fecalase usable for Study of metabolic activity analysis of Deveopment of advanced thechnology evaluation of toxicity induced by drugs by Korea intestinal microflora for quick detection and quantification of intestinal microflora gut microflora Research project 1-3 Research project 2-3 Research project 3-3 Development of in vivo toxicity testing Investigation of database involved in Inspection of Korean intestinal microflora methods using intestinal microflora intestinal microflora diversity according to age, diet and obesity
  12. 12. 4/12/2011
  13. 13.  Recognized as one of most expected and outstanding future technologies in 2010 by KISTEP and MEST Research Publications : Bacteroides faecis sp. nov., isolated from human faeces and so on. Research communications : Korean Society of Pharmacology and so on
  14. 14.  International symposium (Oct 2009)  Colloquium between US-FDA and KFDA (Oct 2009)
  15. 15. Public communication by Mass Media - antibiotics and drug absorption • March 2010
  16. 16. Public communication by Mass Media- Newly identified intestinal microbes from Korean • May 2010
  17. 17. • Aug 2010
  18. 18. Future Prospectives Construction of Korean Intestinal microbes Database  Providing information of Korean intestinal microbes to the public Development of Metagenomic Chip for identification of intestinal microbes Establishment of Korean standard fecalase and developing assay methods Safety evaluation of drug metabolites by intestinal microflora • Screening of drugs susceptible to intestinal microflora metabolism Promotion of personalized medicine based on individual intestinal microflora • Application of individual or ethnic difference of microflora to find adequate dose of drugs

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