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Neuro HIVTanoy


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Department presentation at the Department of Medicine, Assam Medical College & Hospital, kolkata

Department presentation at the Department of Medicine, Assam Medical College & Hospital, kolkata

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  • 1. Approach to Neurological manifestations of HIV infection
    Tanoy Bose
    Dr. R. K. Kotokey
    Professor and In Charge
    ART Centre, AMCH, Dibrugarh
    The Department of Medicine , Assam Medical College
  • 2. What’s wrong with this Lady?
    A 56F habitual blood donor presented with acute onset ascending type of burning paresthesia of all 4 limbs with calf muscle pain & urinary frequency 3 months after last donation. O/e She had loss of pain, position & vibration in a glove and stocking manner with preserved motor function but generalisedareflexia. Over next 3 days she rapidly developed weakness of her neck muscles as well as distal limb muscles and went into respiratory failure on day 5 & was put on ventilator.
    CSF showed elevated protein of 246.8 mg/dL and pleocytosis of 20 cells, with a lymphocyte predominance (L/N = 99/1).
    NCV showed conduction block, slowed conduction velocities, and prolonged F-wave latencies for all sampled nerves consistent with demyelinating polyradiculoneuropathy.
  • 3. The only other positive finding in her investigation was that she was positive for HIV Ag by ELISA on day 5.
    During her last blood donation 3 months back her blood was negative for HIV Ag by ELISA.
  • 4. Neurological Diseases in patients with HIV infection
    Opportunistic infections
    Progressive multifocal leukoencephalopathy
    Mycobacterium tuberculosis
    HTLV-I infection
    Primary CNS lymphoma
    Kaposi's sarcoma
    Result of HIV-1 infection
    HIV-associated neurocognitive impairment, including HIV encephalopathy/AIDS dementia complex
    Aseptic meningitis
    Vacuolar myelopathy
    Pure sensory ataxia
    Peripheral neuropathy
    Acute inflammatory demyelinating polyneuropathy (Guillain-Barré syndrome)
    Chronic inflammatory demyelinating polyneuropathy (CIDP)
    Mononeuritis multiplex
    Distal symmetric polyneuropathy
  • 5. Neurologic complications in patients infected with HIV
    Predominantly nonfocal
    AIDS dementia complex (subacute/chronic HIV encephalitis)
    Acute HIV-related encephalitis
    Cytomegalovirus encephalitis
    Varicella zoster virus encephalitis
    Herpes simplex virus encephalitis
    Metabolic encephalopathies
    Predominantly focal
    Cerebral toxoplasmosis
    Primary CNS lymphoma
    Progressive multifocal leukoencephalopathy
    Brain abscess/tuberculoma
    Neurosyphilis (meningovascular)
    Cerebrovascular disorders
    notably nonbacterial endocarditis,
    cerebral hemorrhages associated with thrombocytopenia, and
    Spinal cord
    Vacuolar myelopathy
    Herpes simplex or zoster myelitis
    Aseptic meningitis (HIV)
    Cryptococcal meningitis
    Tuberculous meningitis
    Syphilitic meningitis
    Metastatic lymphomatous meningitis
    Peripheral nerve and root
    Herpes zoster
    Cytomegalovirus lumbar polyradiculopathy, virus- or
    Acute and chronic inflammatory HIV polyneuritis
    Mononeuritis multiplex
    Sensorimotor demyelinating polyneuropathy
    Distal painful sensory polyneuritis
    Diffuse infiltrative lymphocytic syndrome (DILS)
    Polymyositis and other myopathies (including drug-induced)
  • 6. The Approach to a case
    Risk factors
    Serologic Confirmation
    Classification of HIV status
    Identification of the Anatomical Lesion
    Identification of the Pathology
    Confirmation of Diagnosis
  • 7. Demography, Risks & History
  • 8. Demography, Risks & History continued…
    For Persons (Above 12 Yrs age):
    Two positive tests for HIV infection by ERS test and
    Any of the following;
    1. (a)Significantweight loss ( 10 per cent or more of body weight) within last 1 month) and / or cachexia ( not known to be due to condition other than HIV infection ) and
    (b) Chronic diarrhoea ( intermittent or continuous) > 1 month
    (c) Prolonged fever ( intermittent or continuous) > 1 month
    2. Tuberculosis: disseminated, miliary, extra-pulmonary and extensive pulmonary tuberculosis.
    3. Neurological impairment preventing independent daily activities, not known to be due to the conditions unrelated to HIV infection (e.g. trauma).
    Candidiasis of the oesophagus (odynophagia with oral candidiasis).
    Clinically diangosed life threatening or recurrent episodes of pneumonia with or without etiological confirmation.
    6. Other conditions:
    • Cryptococcal meningitis.
    • 11. Neuro-toxoplasmosis
    • 12. Cytomegalovirus retinitis
    • 13. Penicilliummarneffei infection
    • 14. Recurrent Herpes zoster and multi-dermatomal, and
    • 15. Disseminated molluscum.
  • Serology & Classification
  • 16. Serology & Classification
  • 17. Drug induced Neurotoxicity
    ddI , ddC , d4T
  • 26. Staging of HIV infection
    GB Syndrome
    Aseptic Meningitis
    Herpes Zoster
  • 27. Staging of HIV infection
  • 28. How to localise & categorise the lesion?
  • 29. How to localise & categorise the lesion? Contd…
  • 30. So what was wrong with our patient ?
    A case of Acute DemyelinatingPolyradiculopathythat developed while the patient was having seroconversion as she was tested negative 3 months back while donating blood.
    • In the later stages of HIV infection, the commonest neurologic complication is a subacute or chronic HIV encephalitis .
    • 32. Slowly or rapidly progressive dementia (loss of retentive memory, inattentiveness, language disorder, and apathy)accompanied by abnormalities of motor function.
    • 33. Unable to follow conversations, taking longer to complete daily tasks, and becoming forgetful.
    • 34. Inco-ordination of the limbs, ataxia of gait, and impairment of smooth pursuit and saccadic eye movements -early accompaniments of the dementia.
    • 35. Heightened tendon reflexes, Babinski signs, grasp and suck reflexes, weakness of the legs progressing to paraplegia, bladder and bowel incontinence reflecting spinal cord or cerebral involvement, and abulia or mutism are prominent in the later stages of the disease
    • 36. Tests of psychomotor speed seem to be most sensitive in the early stages of dementia (e.g., trail-making, pegboard, and symbol-digit testing).
    CSF Analysis:
    • Normal or show only a slight elevation of protein content and, less frequently, a mild lymphocytosis.
    • 37. HIV can be isolated from the CSF
    • CT scan : Widening of the sulci and enlargement of the ventricles
    • 38. MRI :may show patchy but confluent or diffuse white matter changes with illdefined margins
  • MRI of AIDS leukoencephalopathy. There are large areas of white matter change that underlie one form of AIDS dementia; cortical atrophy and ventricular enlargement are evident
  • 39. Clinical Staging of HIV encephalopathy (ADC)
  • 40. Aseptic Meningitis
    Seen in any but the very late stages of HIV infection.
    Syndrome of headache, photophobia, and meningismus. Rarely, an acute encephalopathy due to encephalitis
    Cranial nerve involvement may be seen, predominantly cranial nerve VII but occasionally V and/or VIII.
    Usually resolves spontaneously within 2–4 weeks; however, in some patients, signs and symptoms may become chronic.
    Rare following the development of AIDS.
    CSF findings include a lymphocytic pleocytosis, elevated protein level, and normal glucose level
  • 41. AIDS Myelopathy
    Present in ~20% of patients with AIDS, often as part of HIV encephalopathy.
    90% of the patients with HIV-associated myelopathy have some evidence of dementia
    Three main types of spinal cord disease are seen in patients with AIDS.
    Vacuolar myelopathy
    Pathologically similar to subacute combined degeneration of the cord
    Vitamin B12 deficiency can be seen:,it does not appear to be responsible for the myelopathy seen in the majority of patients
    Characterized by a subacute onset and often presents with gait disturbances, predominantly ataxia and spasticity
    May progress to include bladder and bowel dysfunction.
    Increased deep tendon reflexes and extensor plantar responses.
    The second form of spinal cord disease involves the dorsal columns and presents as a pure sensory ataxia.
    The third form is also sensory in nature and presents with paresthesias and dysesthesias of the lower extremities.
    In contrast to the cognitive problems seen in patients with HIV encephalopathy, these spinal cord syndromes do not respond well to ARV drugs, and therapy is mainly supportive
  • 42. AIDS Neuropathy
    Distal, symmetrical, axonal polyneuropathy, predominantly sensory and dysesthetic in type - the most common neuropathic pattern : may be a direct consequence of HIV infection or a side effect of dideoxynucleoside therapy. Painful burning sensations in the feet and lower extremities. Stocking-type sensory loss to pinprick, temperature, and touch sensation and a loss of ankle reflexes. Motor changes are mild and are usually limited to weakness of the intrinsic foot muscles
    Ganglionopathy : Due to Zoster
    Painful mononeuropathy multiplexoccurs, seemingly related to a focal vasculitis
    Subacute inflammatory caudaequina syndrome (a polyradiculitis)that is usually due to an accompanying CMV infection
    Inflammatory demyelinating peripheral neuropathy, of both the acute (Guillain-Barre´)and chronic types, in otherwise asymptomatic patients with HIV infection.
  • 43. AIDS Neuropathy continued…
    Progressive or relapsing-remitting inflammatory neuropathy resembling chronic inflammatory demyelinatingpolyneuropathy (CIDP) : Patients commonly present with progressive weakness, areflexia, and minimal sensory changes
    All patients with inflammatory demyelinatingpolyneuropathies should now be tested for the presence of HIV infection
    Facial palsyis being reported with increasing frequency as a feature of AIDS; its relationship to the generalized polyneuritis of AIDS is uncertain.
    Most of these patients had a mild pleocytosis in addition to an elevated CSF protein content. Also, all of the patients with inflammatory demyelinating neuropathy recovered either spontaneously or in response to plasma exchange suggesting an immunopathogenesis similar to that of the Guillain-Barre´ syndrome.
    For distal symmetric polyneuropathy that fails to resolve following the discontinuation of dideoxynucleosides, therapy is symptomatic; gabapentin, carbamazepine, tricyclics, or analgesics may be effective for dysesthesias.
    Treatment-naive patients may respond to combination ARV therapy.
    Plasma exchange or IVIg has been tried with variable success.
    Because of the immunosuppressive effects of glucocorticoids, they should be reserved for severe cases of CIDP refractory to other measures.
  • 44. AIDS Myopathy
    Causes include HIV infection itself, zidovudine, and the generalized wasting syndrome.
    Range in severity from an asymptomatic elevation in creatinekinase levels to a subacute syndrome characterized by proximal muscle weakness and myalgias. Quite pronounced elevations in creatinekinase may occur in asymptomatic patients, particularly after exercise.
    Profound muscle wasting, often with muscle pain, may be seen after prolonged zidovudine therapy. This toxic side effect of the drug is dose-dependent and is related to its ability to interfere with the function of mitochondrial polymerases. It is reversible following discontinuation of the drug.
    Red ragged fibers are a histologic hallmark of zidovudine-induced myopathy. 
    Raised CreatinineKinase
    Muscle biopsy: Myofiber necrosis with inflammatory cells, nemaline rod bodies, cytoplasmic bodies, and mitochondrial abnormalities.
    Discontinuation of Ziduvudine
    In some of these cases, the myopathy has improved with corticosteroid therapy
  • 45. Oppertunistic Infections of CNS
  • 46. Oppertunistic Infections of CNS continued…
  • 47. Oppertunistic Infections of CNS continued…
  • 48. Conclusion
    Clinical disease of the nervous system accounts for a significant degree of morbidity in a high percentage of patients with HIV infection.
    The neurologic problems that occur in HIV-infected individuals may be either primary to the pathogenic processes of HIV infection or secondary to opportunistic infections or neoplasm
    Among the more frequent opportunistic diseases that involve the CNS are toxoplasmosis, cryptococcosis, progressive multifocal leukoencephalopathy, and primary CNS lymphoma
    Frequency is considerably less in patients receiving effective ARV drugs
  • 49. THANK YOU