Your SlideShare is downloading. ×
Relation between oral infection and systemic infection
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×

Saving this for later?

Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime - even offline.

Text the download link to your phone

Standard text messaging rates apply

Relation between oral infection and systemic infection

1,088
views

Published on

Published in: Education

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
1,088
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
74
Comments
0
Likes
0
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. RELATIONSHIP BETWEEN ORAL INFECTION AND SYSTEMIC DISEASES Presented by: Dr. Shady A. M. Negm *Bachelors Degree of Dental Surgery, School of Dentistry, Pharos University. *Professional Diploma ofInfection Control from Oxford College, UK*Diploma in General Science 1
  • 2. Introduction• Recently, it has been recognized that oral infection, especially periodontitis, may affect the course and pathogenesis of a number of systemic diseases, such as cardiovascular disease, bacterial pneumonia, diabetes mellitus, and low birth weight. 2
  • 3. pathways linking oral infections to secondary systemic• Three mechanisms or pathways linking oral infections to secondary systemic effects have been proposed: (i) metastatic spread of infection from the oral cavity as a result of transient bacteremia, (ii) metastatic injury from the effects of circulating oral microbial toxins, and (iii) metastatic inflammation caused by immunological injury induced by oral microorganisms 3
  • 4. Cardiovascular Disease• It is clear that periodontal disease is capable of predisposing individuals to cardiovascular disease, given the abundance of gram-negative species involved, the readily detectable levels of proinflammatory cytokines, the heavy immune and inflammatory infiltrates involved, the association of high peripheral fibrinogen, and the white blood cell (WBC) counts 4
  • 5. 5
  • 6. Bacterial Pneumonia• Microorganisms can infect the lower respiratory tracts by four possible routes: aspiration of oropharyngeal contents, inhalation of infectious aerosols, spread of infection from contiguous sites, and hematogenous spread from extrapulmonary sites of infection. 6
  • 7. 7
  • 8. Low Birth Weight• Pregnancy can influence gingival health. Changes in hormone levels during pregnancy promote an inflammation termed pregnancy gingivitis. This type of gingivitis may occur without changes in plaque levels. Oral contraceptives may also produce changes in gingival health. Some birth control pill users have a high gingival inflammation level but a low plaque level. Birth control pills may cause changes such as alteration of the microvasculature, gingival permeability, and increased synthesis of estrogen PGs 8
  • 9. 9
  • 10. Diabetes Mellitus• Diabetes is commonly categorized as type 1, or insulin dependent, and type 2, non- insulin dependent. The fundamental derangement in insulin-dependent diabetes is the hypoproduction of insulin due to destruction of the beta cells of the pancreas. In non-insulin-dependent diabetes, the derangement involves resistance of target tissue to insulin action 10
  • 11. • Severe periodontal disease often coexists with severe diabetes mellitus. Diabetes is a risk factor for severe periodontal disease. The converse possibility that periodontal disease either predisposes or exacerbates the diabetic condition has received more and more attention 11
  • 12. • Recently, a new model was presented by Grossi and Genco, in which severe periodontal disease increases the severity of diabetes mellitus and complicates metabolic control 12
  • 13. 13
  • 14. 14finish lines