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Mixed Connective Tissue Disorders.ppt Mixed Connective Tissue Disorders.ppt Presentation Transcript

  • MIXED CONNECTIVE TISSUE DISORDERS
  • DEFINITION
    • Connective tissue is the material inside the body that supports many of its parts.
    • It is the “cellular glue” that gives the tissues their shape and helps keep them strong.
    • It also helps some of the tissues do their work.
    • Cartilage and fat are examples of connective tissue.
  • INTRODUCTION
    • Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that causes signs and symptoms of other mixed connective tissue diseases.
    • People with mixed connective tissue disease experience features of three other diseases — lupus, scleroderma and polymyositis.
    • For this reason, mixed connective tissue disease is sometimes referred to as an overlap disease.
    • Signs and symptoms of these three other diseases usually don't appear all at once.
    • This makes diagnosing mixed connective tissue disease somewhat complicated.
    • Often people with mixed connective tissue disease are first diagnosed with lupus.
    • As the disease progresses and other signs and symptoms become apparent, the diagnosis is corrected.
    • Mixed connective tissue disease occurs most often in women and is usually diagnosed in young adults in their 20s and 30s.
    • Children have also been diagnosed with mixed connective tissue disease.
    • Mixed xonnective tissue disease is somewhat of a controversial term among arthritis specialists (rheumatologists).
    • Some question whether mixed connective tissue disease is its own specific disease or whether it's a precursor to another connective tissue disease.
  • showing a representative case of a generalized connective tissue disorder in spontaneous intracranial hypotension.
  • SIGNS AND SYMPTOMS
    • Mixed connective tissue disease doesn't have a unique set of signs and symptoms.
    • Instead, people with mixed connective tissue disease usually have signs and symptoms of lupus, scleroderma and polymyositis, including:
    • 1. Fatigue 2. Muscle weakness
    • 3. Joint pain 4. Joint swelling
    • 5. Swollen fingers 6. Mild fever
    • 7. Raynaud's phenomenon — blood vessel spasms that interrupt blood flow to the fingers, toes, ears and nose
  • CAUSES
    • Doctors don't know what causes mixed connective tissue disease.
    • The disease is part of a larger group of diseases known as autoimmune disorders.
    • When he/she have an autoimmune disorder, the immune system – the part of the body is responsible for fighting off disease – mistakes normal, healthy cells for intruders.
    • As a result, healthy tissue in the body is damaged, causing signs and symptoms of disease.
    • It isn't clear what causes immune system to attack the body.
    • Doctors believe a complex mix of viruses, chemicals and genetic factors may be at play.
  • RISK FACTORS
    • Doctors don't know what puts at risk of mixed connective tissue disease.
    • Other findings show an increased risk in people exposed to certain chemicals, including vinyl chloride and silica.
    • More research is needed to confirm these findings.
  • WHEN TO SEEK MEDICAL ADVICE
    • Signs and symptoms of mixed connective tissue disease usually begin mildly and may not prompt to seek medical attention.
    • But if signs and symptoms become bothersome or interfere with daily routine, make an appointment with the doctor.
    • Also see the doctor if having been diagnosed with lupus or another connective tissue disease and begin developing new signs and symptoms.
  • SCREENING AND DIAGNOSIS
    • Doctor may suspect mixed connective tissue disease based on the signs and symptoms.
    • He or she will conduct a physical exam to look for signs such as swollen hands and painful, swollen joints.
    • A blood test determines the presence of certain antibody in the blood that indicates connective tissue disease.
    • The presence of this specific antibody – called U1-RNP – can confirm the doctor's suspicions.
    • Mixed connective tissue disease usually develops slowly, making it difficult to diagnose.
    • Many people are first diagnosed with lupus and later re-diagnosed with mixed connective tissue disease.
    • Others begin with a diagnosis of connective tissue disease only to later find they have lupus or another mixed connective tissue disorder.
  • COMPLICATIONS
    • Pulmonary hypertension.
    • Heart disease.
    • Side effects of long-term steroid use.
    • Pregnancy complications.
  • TREATMENT
    • No cure exists for connective tissue disease, although treatments can help manage the signs and symptoms of the disease.
    • Treatment may vary from one person to another because the signs and symptoms may be different.
    • While no standard treatment exists, the most common treatment for mixed connective tissue disease is corticosteroids, such as prednisone.
    • People with mild forms of mixed connective tissue disease may not need any treatment.
    • Or may require treatment only during flares or
    • May require constant medication.
    • Work with doctor to ensure that the signs and symptoms are adequately controlled.
  • SPECIFIC PRACTICE
  •